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Agosto 2012 PDF Imprimir E-mail
Escrito por Administrador General de SAMFyC   
Miércoles, 05 de Septiembre de 2012 00:00

SELECCIÓN DE REFERENCIAS BIBLIOGRÁFICAS DE LO PUBLICADO EN RELACIÓN CON ATENCIÓN PRIMARIA

Selección realizada por Antonio Manteca González
  
ACADEMIC MEDICINE
 
Dyrbye LN, Harper W, Moutier C, Durning SJ, Power DV, Massie FS, et al. A multi-institutional study exploring the impact of positive mental health on medical students' professionalism in an era of high burnout. Acad Med. 2012; 87:1024-1031 [T,I]
22722352             R/C
ESTUDIO MULTIINSTITUCIONAL PARA EXPLORAR EL IMPACTO DE LA SALUD MENTAL POSITIVA SOBRE LA PROFESIONALIDAD DE LOS ESTUDIANTES EN UNA ÉPOCA DE GRAN DESGASTE
 
ANNALS OF INTERNAL MEDICINE
 
Hebert C, Beaumont J, Schwartz G, Robicsek A. The influence of context on antimicrobial prescribing for febrile respiratory illness: a cohort study. Ann Intern Med. 2012; 157:160-169 [S,I]
22868833             R/C
INFLUENCIA DEL CONTEXTO SOBRE LA PRESCRIPCIÓN DE ANTIMICROBIANOS EN LA ENFERMEDAD FEBRIL RESPIRATORIA: ESTUDIO DE COHORTES
 
Moyer VA; on behalf of the U.S. Preventive Services Task Force. Prevention of falls in community-dwelling older adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012; 157:197-204 [M,II]
22868837             R/C
PREVENCIÓN DE CAÍDAS EN ANCIANOS RESIDENTES EN LA COMUNIDAD: DECLARACIÓN DE RECOMENDACIÓN DEL US PREVENTIVE SERVICES TASK FORCE
 
Ackerman S, Gonzales R. The context of antibiotic overuse. Ann Intern Med. 2012; 157:211-212 [AO,I]
EL CONTEXTO DEL USO EXCESIVO DE ANTIBIÓTICOS
 
Brenner H, Chang-Claude J, Jansen L, Seiler CM, Hoffmeister M. Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection: a population-based case-control study. Ann Intern Med. 2012; 157:225-232 [CC,I]
22910933             R/C
PAPEL DE LA COLONOSCOPIA Y CARACTERÍSTICAS DE LOS PÓLIPOS EN EL CÁNCER COLORRECTAL TRAS LA DETECCIÓN COLONOSCÓPICA DE PÓLIPOS: ESTUDIO CASO-CONTROL POBLACIONAL
 
Raji OY, Duffy SW, Agbaje OF, Baker SG, Christiani DC, Cassidy A, et al. Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study. Ann Intern Med. 2012; 157:242-250 [S-CC,I]
22910935             R/C
EXACTITUD PREDICTIVA DEL MODELO DE RIESGO PROYECTO PULMÓN DE LIVERPOOL PARA ESTRATIFICAR A LOS PACIENTES PARA EL CRIBAJE DE CÁNCER DE PULMÓN MEDIANTE TAC: ESTUDIO DE VALIDACIÓN DE CASO-CONTROL Y COHORTES
 
ARCHIVES OF INTERNAL MEDICINE
 
Hoffman JR, Cooper RJ. Overdiagnosis of disease: a modern epidemic. Arch Intern Med. 2012; 172:1123-1124 [AO,II]
SOBREDIAGNÓSTICO DE ENFERMEDAD: EPIDEMIA MODERNA
 
Odden MC, Peralta CA, Haan MN, Covinsky KE. Rethinking the association of high blood pressure with mortality in elderly adults: the impact of frailty. Arch Intern Med. 2012; 172:1162-1168 [T,II]
22801930             R/C
REPENSAR LA ASOCIACIÓN DE LA PRESIÓN ARTERIAL ELEVADA CON LA MORTALIDAD EN LOS ANCIANOS: IMPACTO DE LA FRAGILIDAD
 
Goodwin JS. Gait speed: comment on "rethinking the association of high blood pressure with mortality in elderly adults". Arch Intern Med. 2012; 172:1168-1169 [AO,I]
VELOCIDAD DE MARCHA: COMENTARIO SOBRE "REPENSAR LA ASOCIACIÓN DE LA PRESIÓN ARTERIAL ELEVADA CON LA MORTALIDAD EN LOS ANCIANOS"
 
ARCHIVOS DE BRONCONEUMOLOGIA
 
Rodríguez-Roisin R, Agustí A. Iniciativa GOLD 2011 ¿Cambio de paradigma? Arch Bronconeumol. 2012; 48:286-289 [R,II]
22537593             R/C
INICIATIVA GOLD 2011 ¿CAMBIO DE PARADIGMA?
 
Ruiz J, Alfageme I, Chiner E, Martínez C. Valoración de la discapacidad en los enfermos respiratorios. Arch Bronconeumol. 2012; 48:290-295 [R,I]
22341300             R/C
VALORACIÓN DE LA DISCAPACIDAD EN LOS ENFERMOS RESPIRATORIOS
 
ATENCION PRIMARIA
 
Medicamentos: hay que escoger pero, ¿sabemos hacerlo? Aten Primaria. 2012; 44:449-450 [AO,I]
MEDICAMENTOS: HAY QUE ESCOGER PERO, ¿SABEMOS HACERLO?
 
Molina T, Domínguez JC, Palma D, Caraballo Mde L, Morales JC, López S. Revisión de la medicación en ancianos polimedicados en riesgo vascular: ensayo aleatorizado y controlado. Aten Primaria. 2012; 44:453-460 [EC,I]
22341703             R/C
REVISIÓN DE LA MEDICACIÓN EN ANCIANOS POLIMEDICADOS EN RIESGO VASCULAR: ENSAYO ALEATORIZADO Y CONTROLADO
 
Alvarez-Ibáñez C, Guerra-García MM. Evolución de la incidencia de la hemorragia digestiva alta en España en relación con el consumo de antiulcerosos. Aten Primaria. 2012; 44:478-484 [T,I]
22657738             R/C
EVOLUCIÓN DE LA INCIDENCIA DE LA HEMORRAGIA DIGESTIVA ALTA EN ESPAÑA EN RELACIÓN CON EL CONSUMO DE ANTIULCEROSOS
Borrell F. Seguridad clínica en atención primaria. Los errores médicos (II). Aten Primaria. 2012; 44:494-502 [R,II]
22055915             R/C
SEGURIDAD CLÍNICA EN ATENCIÓN PRIMARIA. LOS ERRORES MÉDICOS (II)
 
BRITISH JOURNAL OF PSYCHIATRY
 
Mitchell AJ, Meader N, Bird V, Rizzo M. Clinical recognition and recording of alcohol disorders by clinicians in primary and secondary care: meta-analysis. Br J Psychiatry. 2012; 201:93-100 [T,I]
22859576             R/C
RECONOCIMIENTO CLÍNICO Y REGISTRO DE LOS TRASTORNOS DEL ALCOHOL POR PARTE DE LOS CLÍNICOS DE ATENCIÓN PRIMARIA Y SECUNDARIA: METAANÁLISIS
 
Fernández A, Mendive JM, Salvador-Carulla L, Rubio-Valera M, Luciano JV, Pinto-Meza A, et al; the DASMAP investigators. Adjustment disorders in primary care: prevalence, recognition and use of services. Br J Psychiatry. 2012; 201:137-142 [T,I]
22576725             R/C
TRASTORNOS ADAPTATIVOS EN ATENCIÓN PRIMARIA: PREVALENCIA, RECONOCIMIENTO Y USO DE LOS SERVICIOS
 
BRITISH MEDICAL JOURNAL
 
Poole KE, Compston JE. Bisphosphonates in the treatment of osteoporosis. BMJ. 2012; 344:e3211 [T,I]
BIFOSFONATOS EN EL TRATAMIENTO DE LA OSTEOPOROSIS
 
Turnbull AM, Mayfield MP. Blepharitis. BMJ. 2012; 344:e3328 [R,I]
BLEFARITIS
 
Wand BM, Heine PJ, O'Connell NE. Should we abandon cervical spine manipulation for mechanical neck pain? Yes. BMJ. 2012; 344:e3679 [AO,I]
¿DEBERÍAMOS ABANDONAR LA MANIPULACIÓN DE LA COLUMNA CERVICAL PARA EL DOLOR MECÁNICO DE CUELLO?
 
Cassidy JD, Bronfort G, Hartvigsen J. Should we abandon cervical spine manipulation for mechanical neck pain? No. BMJ. 2012; 344:e3680 [AO,I]
¿DEBERÍAMOS ABANDONAR LA MANIPULACIÓN DE LA COLUMNA CERVICAL PARA EL DOLOR MECÁNICO DE CUELLO?NO
 
Rabar S, Lau R, O'Flynn N, Li L, Barry P; on behalf of the Guideline Development Group. Risk assessment of fragility fractures: summary of NICE guidance. BMJ. 2012; 345:e3698 [M,III]
VALORACIÓN DEL RIESGO DE LAS FRACTURAS POR FRAGILIDAD: RESUMEN DE LA GUÍA NICE
 
Andersen B, Olesen F. Screening for Chlamydia trachomatis. BMJ. 2012; 345:e4231 [AO,I]
CRIBAJE DE CHLAMYDIA TRACHOMATIS
 
Caldeira D, Alarcão J, Vaz-Carneiro A, Costa J. Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis. BMJ. 2012; 345:e4260 [M,II]
22786934             R/C
RIESGO DE NEUMONÍA ASOCIADO CON EL USO DE INHIBIDORES DE LA ENZIMA CONVERSORA DE ANGIOTENSINA Y BLOQUEADORES DEL RECEPTOR DE LA ANGIOTENSINA: REVISIÓN SISTEMÁTICA Y METAANÁLISIS
 
Douglas IJ, Evans SJ, Hingorani AD, Grosso AM, Timmis A, Hemingway H, Smeeth L. Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ. 2012; 345:e4388 [S,II]
22782731             R/C
CLOPIDOGREL E INTERACCIÓN CON LOS IBP: COMPARACIÓN ENTRE DISEÑOS DE ESTUDIOS DE COHORTES Y CON PERSONAS
 
Aubin HJ, Farley A, Lycett D, Lahmek P, Aveyard P. Weight gain in smokers after quitting cigarettes: meta-analysis. BMJ. 2012; 345:e4439 [M,II]
22782848             R/C
GANANCIA DE PESO EN FUMADORES TRAS ABANDONAR LOS CIGARRILLOS: METAANÁLISIS
 
Lugnér AK, van Boven M, de Vries R, Postma MJ, Wallinga J. Cost effectiveness of vaccination against pandemic influenza in European countries: mathematical modelling analysis. BMJ. 2012; 345:e4445 [CE,I]
22791791             R/C
RENTABILIDAD DE LA VACUNACIÓN CONTRA LA GRIPE PANDÉMICA EN LOS PAÍSES EUROPEOS: ANÁLISIS CON MODELOS MATEMÁTICOS
 
Fernández E, Chapman S. Quitting smoking and gaining weight: the odd couple. BMJ. 2012; 345:e4544 [AO,I]
ABANDONO DEL TABACO Y GANANCIA DE PESO: LA EXTRAÑA PAREJA
 
Thrumurthy SG, Date RS, Mughal M. Is surgery a magic bullet against diabetes? BMJ. 2012; 345:e4552 [AO,I]
¿ES LA CIRUGÍA LA PANACEA CONTRA LA DIABETES?
 
Targownik LE. Prescribing proton pump inhibitors with clopidogrel. BMJ. 2012; 345:e4558 [R,I]
PRESCRIPCIÓN DE IBP CON CLOPIDOGREL
 
Barnes RA. Pneumonia and ACE inhibitors--and cough. BMJ. 2012; 345:e4566 [R,I]
NEUMONÍA E INHIBIDORES DE LA ECA--Y TOS
 
Clemson L, Fiatarone Singh MA, Bundy A, Cumming RG, Manollaras K, O'Loughlin P, et al. Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial. BMJ. 2012; 345:e4547 [EC,I]
22872695             R/C
INTEGRACIÓN DEL ENTRENAMIENTO EN EQUILIBRIO Y FORTALEZA EN LAS ACTIVIDADES DE LA VIDA DIARIA PARA REDUCIR LA TASA DE CAÍDAS EN ANCIANOS (ESTUDIO LIFE): ENSAYO PARALELO ALEATORIZADO
 
Waldorff FB, Buss DV, Eckermann A, Rasmussen ML, Keiding N, Rishøj S, et al. Efficacy of psychosocial intervention in patients with mild Alzheimer's disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY). BMJ. 2012; 345:e4693 [EC,I]
22807076             R/C
EFICACIA DE LA INTERVENCIÓN PSICOSOCIAL EN PACIENTES CON ENFERMEDAD DE ALZHEIMER LEVE: ESTUDIO DAISY, MULTICÉNTRICO, ALEATORIZADO, ENMASCARADO PARA EL EVALUADOR
 
Harvey NC, Cooper C. Vitamin D: some perspective please. BMJ. 2012; 345:e4695 [AO,I]
VITAMINA D: ALGO DE PERSPECTIVA, POR FAVOR
 
Rudd AG, Wolfe CD. Is early speech and language therapy after stroke a waste? BMJ. 2012; 345:e4870 [R,I]
¿ES UNA PÉRDIDA DE TIEMPO EL HABLA PRECOZ Y LA TERAPIA DEL LENGUAJE TRAS UN ICTUS?
 
Hunter D, Wilson J. Promoting health equity. BMJ. 2012; 345:e4881 [AO,I]
PROMOVER LA EQUIDAD SANITARIA
 
Morris ME. Preventing falls in older people. BMJ. 2012; 345:e4919 [AO,I]
PREVENIR LAS CAÍDAS EN LOS ANCIANOS
 
Bennell KL, Hunter DJ, Hinman RS. Management of osteoarthritis of the knee. BMJ. 2012; 345:e4934 [R,I]
MANEJO DE LA ARTROSIS DE RODILLA
 
Mantha S, Karp R, Raghavan V, Terrin N, Bauer KA, Zwicker JI. Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis. BMJ. 2012; 345:e4944 [M,II]
22872710             R/C
VALORAR EL RIESGO DE ACONTECIMIENTOS TROMBOEMBÓLICOS EN MUJERES QUE TOMAN ANTICONCEPTIVOS SÓLO CON PROGESTINA: METAANÁLISIS
 
Ring A. Treating cancer in older people. BMJ. 2012; 345:e4954 [AO,I]
TRATAR EL CÁNCER EN LOS ANCIANOS
 
Tomlinson CL, Patel S, Meek C, Herd CP, Clarke CE, Stowe R, et al. Physiotherapy intervention in Parkinson's disease: systematic review and meta-analysis. BMJ. 2012; 345:e5004 [M,II]
22867913             R/C
INTERVENCIÓN DE FISIOTERAPIA EN LA ENFERMEDAD DE PARKINSON: REVISIÓN SISTEMÁTICA Y METAANÁLISIS
 
Woolhandler S, Ariely D, Himmelstein DU. Why pay for performance may be incompatible with quality improvement. BMJ. 2012; 345:e5015 [AO,I]
POR QUÉ EL PAGO POR RENDIMIENTO PUEDE SER INCOMPATIBLE CON LA MEJORA DE LA CALIDAD
 
Parker C. Treating prostate cancer. BMJ. 2012; 345:e5122 [AO,I]
TRATAR EL CÁNCER DE PRÓSTATA
 
Morin SF, Yamey G, Rutherford GW. HIV pre-exposure prophylaxis. BMJ. 2012; 345:e5412 [R,I]
PROFILAXIS PREEXPOSICIÓN AL VIH
 
Rayman G, Kilvert A. The crisis in diabetes care in England. BMJ. 2012; 345:e5446 [AO,I]
LA CRISIS EN LA ATENCIÓN A LA DIABETES EN INGLATERRA
 
CIRCULATION
 
Krakoff LR. Fluctuation: does blood pressure variability matter? Circulation. 2012; 126:525-527 [AO,I]
FLUCTUACIÓN: ¿IMPORTA LA VARIABILIDAD DE LA PRESIÓN ARTERIAL?
 
Wenger NK. Women and coronary heart disease: a century after Herrick: understudied, underdiagnosed, and undertreated. Circulation. 2012; 126:604-611 [R,I]
MUJERES Y ENFERMEDAD CARDIACA CORONARIA: UN SIGLO DESPUÉS DE HERRICK: INFRAESTUDIADA, INFRADIAGNOSTICADA E INFRATRATADA
 
Hindricks G, Piorkowski C. Atrial fibrillation monitoring: mathematics meets real life. Circulation. 2012; 126:791-792 [AO,I]
MONITORIZACIÓN DE LA FIBRILACIÓN AURICULAR: LAS MATEMÁTICAS SE ENCUENTRAN CON LA VIDA REAL
 
Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE Jr, et al; 2012 Writing Committee Members. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2012; 126:875-910 [M,III]
ACTUALIZACIÓN FOCALIZADA DE LA GUÍA ACCF/AHA PARA EL MANEJO DE LOS PACIENTES CON ANGINA INESTABLE/INFARTO DE MIOCARDIO SIN ELEVACIÓN DE ST (ACTUALIZACIÓN DE LA GUÍA 2007 Y REEMPLAZO DE LA ACTUALIZACIÓN FOCALIZADA DE 2011): INFORME DEL GRUPO DE TRABAJO SOBRE GUÍAS CLÍNICAS DE LA AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION/AMERICAN HEART ASSOCIATION
 
Lam CS, Little WC. Sex and cardiovascular risk. Circulation. 2012; 126:913-915 [AO,I]
SEXO Y RIESGO CARDIOVASCULAR
 
Mottram AR, Page RL. Advances in resuscitation. Circulation. 2012; 126:991-1002 [R,II]
AVANCES EN REANIMACIÓN
 
CANADIAN MEDICAL ASSOCIATION JOURNAL
 
Flegel K, Fletcher J. Choosing when and how to die: Are we ready to perform therapeutic homicide? CMAJ. 2012; 184:1227 [AO,II]
ESCOGER CUÁNDO Y CÓMO MORIR: ¿ESTAMOS PREPARADOS PARA LLEVAR A CABO EL HOMICIDIO TERAPÉUTICO?
 
Buchbinder R, Underwood M. Prognosis in people with back pain. CMAJ. 2012; 184:1229-1230 [AO,I]
PRONÓSTICO EN PERSONAS CON DOLOR DE ESPALDA
 
Vaucher P, Druais PL, Waldvogel S, Favrat B. Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. CMAJ. 2012; 184:1247-1254 [EC,II]
22777991             R/C
EFECTO DE LOS SUPLEMENTOS DE HIERRO SOBRE LA FATIGA EN MUJERES NO ANÉMICAS CON MENSTRUACIÓN CON FERRITINA BAJA: ENSAYO ALEATORIZADO CONTROLADO
 
Menezes Lda C, Maher CG, Hancock MJ, McAuley JH, Herbert RD, Costa LO. The prognosis of acute and persistent low-back pain: a meta-analysis. CMAJ. 2012; 184:E613-E624 [M,II]
22586331             R/C
PRONÓSTICO DEL DOLOR LUMBAR AGUDO Y PERSISTENTE: METAANÁLISIS
 
DIABETES CARE
 
Picón MJ, Murri M, Muñoz A, Fernández-García JC, Gomez-Huelgas R, Tinahones FJ. Hemoglobin a1c versus oral glucose tolerance test in postpartum diabetes screening. Diabetes Care. 2012; 35:1648-1653 [T,I]
22688550             R/C
HBA1C FRENTE AL TEST DE TOLERANCIA ORAL A LA GLUCOSA EN EL CRIBAJE DE LA DIABETES POSTPARTO
 
Chalk D, Pitt M, Vaidya B, Stein K. Can the retinal screening interval be safely increased to 2 years for type 2 diabetic patients without retinopathy? Diabetes Care. 2012; 35:1663-1668 [S,I]
22566535             R/C
¿PUEDE INCREMENTARSE CON SEGURIDAD EL INTERVALO DE CRIBAJE RETINIANO HASTA LOS 2 AÑOS EN LOS PACIENTES DIABÉTICOS TIPO 2 SIN RETINOPATÍA?
 
Chae JS, Kang R, Kwak JH, Paik JK, Kim OY, Kim M, et al. Supervised exercise program, BMI, and risk of type 2 diabetes in subjects with normal or impaired fasting glucose. Diabetes Care. 2012; 35:1680-1685 [S,II]
22688549             R/C
PROGRAMA SUPERVISADO DE EJERCICIO, IMC Y RIESGO DE DIABETES TIPO 2 EN SUJETOS CON GLUCOSA NORMAL O GLUCOSA BASAL ALTERADA
 
Fretts AM, Howard BV, McKnight B, Duncan GE, Beresford SA, Calhoun D, et al. Modest levels of physical activity are associated with a lower incidence of diabetes in a population with a high rate of obesity: the Strong Heart Family study. Diabetes Care. 2012; 35:1743-1745 [S,II]
22723343             R/C
NIVELES MODESTOS DE ACTIVIDAD FÍSICA SE ASOCIAN CON UNA MENOR INCIDENCIA DE DIABETES EN UNA POBLACIÓN CON TASA ELEVADA DE OBESIDAD: ESTUDIO STRONG HEART FAMILY
 
Gardner C, Wylie-Rosett J, Gidding SS, Steffen LM, Johnson RK, Reader D, et al; on behalf of the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on
Cardiovascular Disease in the Young, and the American D. Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2012; 35:1798-1808 [M,III]
ENDULZANTES NO NUTRITIVOS: USO ACTUAL Y PERSPECTIVAS PARA LA SALUD: DECLARACIÓN CIENTÍFICA DE LA AHA Y LA ADA
 
DRUGS
 
Abadilla KA, Dobs AS. Topical testosterone supplementation for the treatment of male hypogonadism. Drugs. 2012; 72:1591-1603 [R,I]
22867042             R/C
SUPLEMENTOS DE TESTOSTERONA TÓPICA EN EL TRATAMIENTO DEL HIPOGONADISMO MASCULINO
 
Tang RS, Chan FK. Therapeutic management of recurrent peptic ulcer disease. Drugs. 2012; 72:1605-1616 [R,I]
22867043             R/C
MANEJO TERAPÉUTICO DE LA ENFERMEDAD ULCEROSA PÉPTICA RECURRENTE
 
Kaakeh Y, Overholser BR, Lopshire JC, Tisdale JE. Drug-induced atrial fibrillation. Drugs. 2012; 72:1617-1630 [R,I]
22834678             R/C
FIBRILACIÓN AURICULAR INDUCIDA POR FÁRMACOS
 
Scott LJ. Exenatide extended-release: a review of its use in type 2 diabetes mellitus. Drugs. 2012; 72:1679-1707 [R,I]
22867046             R/C
EXENATIDA DE LIBERACIÓN PROLONGADA: REVISIÓN DE SU USO EN LA DIABETES MELLITUS TIPO 2
 
EUROPEAN HEART JOURNAL
 
Hohnloser SH, Eikelboom JW. The hazards of interrupting anticoagulation therapy in atrial fibrillation. Eur Heart J.  2012; 33:1864-1866 [AO,I]
LOS PELIGROS DE INTERRUMPIR EL TRATAMIENTO ANTICOAGULANTE EN LA FIBRILACIÓN AURICULAR
 
Ruschitzka F, Taddei S. Angiotensin-converting enzyme inhibitors: first-line agents in cardiovascular protection? Eur Heart J. 2012; 33:1996-1998 [AO,I]
INHIBIDORES DE LA ENZIMA CONVERSORA DE LA ANGIOTENSINA: ¿AGENTES DE PRIMERA LÍNEA EN PROTECCIÓN CARDIOVASCULAR?
 
Bäck M, Yin L, Ingelsson E. Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib. Eur Heart J. 2012; 33:1928-1933 [S,II]
22108833             R/C
INHIBIDORES DE LA CICLOOXIGENASA 2 Y RIESGO CARDIOVASCULAR EN UN ESTUDIO DE COHORTES DE ÁMBITO NACIONAL TRAS LA RETIRADA DEL ROFECOXIB
 
Thygesen K, Mair J, Mueller C, Huber K, Weber M, Plebani M, et al. Recommendations for the use of natriuretic peptides in acute cardiac care: a position statement from the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Eur Heart J. 2012; 33:2001-2006 [M,II]
RECOMENDACIONES PARA EL USO DE LOS PÉPTIDOS NATRIURÉTICOS EN LA ATENCIÓN CARDIACA AGUDA: DECLARACIÓN DE LA POSICIÓN DEL GRUPO DE ESTUDIOS SOBRE BIOMARCADORES EN CARDIOLOGÍA DEL GRUPO DE TRABAJO SOBRE ATENCIÓN CARDIACA AGUDA DE LA ESC
 
FAMILY PRACTICE
 
Dunt D, McKenzie R. Improving the quality of qualitative studies: do reporting guidelines have a place? Fam Pract. 2011; 29:367-369 [AO,I]
MEJORAR LA CALIDAD DE LOS ESTUDIOS CUALITATIVOS: ¿OCUPAN UN LUGAR LAS PAUTAS SOBRE COBERTURA?
 
Myers MG, Godwin M, Dawes M, Kiss A, Tobe SW, Kaczorowski J. Conventional versus automated measurement of blood pressure in the office (CAMBO) trial. Fam Pract. 2011; 29:376-382 [EC,I]
22117083             R/C
ENSAYO DE MEDIDA DE PRESIÓN ARTERIAL AUTOMATIZADA FRENTE A LA CONVENCIONAL EN LA CONSULTA (CAMBO)
 
Engel MF, Paling FP, Hoepelman AI, van der Meer V, Oosterheert JJ. Evaluating the evidence for the implementation of C-reactive protein measurement in adult patients with suspected lower respiratory tract infection in primary care: a systematic review. Fam Pract. 2011; 29:383-393 [M,II]
22159030             R/C
EVALUAR LA EVIDENCIA PARA LA PUESTA EN MARCHA DE LA MEDIDA DE LA PROTEÍNA C REACTIVA EN PACIENTES ADULTOS CON SOSPECHA DE INFECCIÓN DE VÍAS RESPIRATORIAS BAJAS EN ATENCIÓN PRIMARIA: REVISIÓN SISTEMÁTICA
 
Cruz-Orduña I, Bellón JM, Torrero P, Aparicio E, Sanz A, Mula N, et al. Detecting MCI and dementia in primary care: efficiency of the MMS, the FAQ and the IQCODE. Fam Pract. 2011; 29:401-406 [T,I]
22121012             R/C
DETECTAR EL TRASTORNO COGNITIVO LEVE Y LA DEMENCIA EN ATENCIÓN PRIMARIA: EFICIENCIA DEL MMS, EL FAQ Y EL IQCODE
 
Jogerst GJ, Zheng S, Frolova EV, Kim MY. Late-life depressive symptoms: an international study. Fam Pract. 2011; 29:407-415 [T,I]
22147242             R/C
SÍNTOMAS DEPRESIVOS EN LA EDAD AVANZADA: ESTUDIO INTERNACIONAL
 
Taylor A, Stapley S, Hamilton W. Jaundice in primary care: a cohort study of adults aged >45 years using electronic medical records. Fam Pract. 2011; 29:416-420 [S,I]
22247287             R/C
ICTERICIA EN ATENCIÓN PRIMARIA: ESTUDIO DE COHORTES DE INDIVIDUOS POR ENCIMA DE LOS 45 AÑOS MEDIANTE EL USO DE REGISTROS MÉDICOS ELECTRÓNICOS
 
Reason B, Terner M, Moses McKeag A, Tipper B, Webster G. The impact of polypharmacy on the health of Canadian seniors. Fam Pract. 2011; 29:427-432 [T,I]
22223743             R/C
IMPACTO DE LA POLIMEDICACIÓN SOBRE LA SALUD DE LOS MAYORES CANADIENSES
 
GUT
 
Hassan C, Rex DK, Cooper GS, Zullo A, Launois R, Benamouzig R. Primary prevention of colorectal cancer with low-dose aspirin in combination with endoscopy: a cost-effectiveness analysis. Gut. 2012; 61:1172-1179 [CE,I]
21997545             R/C
PREVENCIÓN PRIMARIA DEL CÁNCER COLORRECTAL CON ASPIRINA EN BAJAS DOSIS EN COMBINACIÓN CON LA ENDOSCOPIA: ANÁLISIS DE RENTABILIDAD
 
Cottet V, Jooste V, Fournel I, Bouvier AM, Faivre J, Bonithon-Kopp C. Long-term risk of colorectal cancer after adenoma removal: a population-based cohort study. Gut. 2012; 61:1180-1186 [S,I]
22110052             R/C
RIESGO A LARGO PLAZO DE CÁNCER COLORRECTAL TRAS LA EXTIRPACIÓN DE ADENOMA: ESTUDIO DE COHORTES POBLACIONAL
 
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
 
Landon BE, Grumbach K, Wallace PJ. Integrating public health and primary care systems: potential strategies from an IOM report. JAMA. 2012; 308:461-462 [AO,I]
INTEGRAR LOS SISTEMAS DE SALUD PÚBLICA Y DE ATENCIÓN PRIMARIA: ESTRATEGIAS POTENCIALES DEL INFORME IOM
 
Blumenthal JA, Babyak MA, O'Connor C, Keteyian S, Landzberg J, Howlett J, et al. Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA. 2012; 308:465-474 [EC,I]
22851113             R/C
EFECTOS DEL EJERCICIO DE ENTRENAMIENTO SOBRE LOS SÍNTOMAS DEPRESIVOS EN PACIENTES CON INSUFICIENCIA CARDIACA CRÓNICA: ENSAYO ALEATORIZADO HF-ACTION
 
Klevens J, Kee R, Trick W, Garcia D, Angulo FR, Jones R, et al. Effect of screening for partner violence on women's quality of life: a randomized controlled trial. JAMA. 2012; 308:681-689 [EC,I]
22893165            R/C
EFECTO DEL CRIBAJE DE VIOLENCIA DE PAREJA SOBRE LA CALIDAD DE VIDA DE LAS MUJERES: ENSAYO CONTROLADO ALEATORIZADO
 
Wathen CN, MacMillan HL. Health care's response to women exposed to partner violence: moving beyond universal screening. JAMA. 2012; 308:712-713 [AO,I]
RESPUESTA DE LA ATENCIÓN SANITARIA A LAS MUJERES EXPUESTAS A LA VIOLENCIA DE PAREJA: IR MÁS ALLÁ DEL CRIBAJE UNIVERSAL
 
Koh HK, Sebelius KG. Ending the tobacco epidemic. JAMA. 2012; 308:767-768 [AO,I]
ACABAR CON LA EPIDEMIA DEL TABACO
 
Yeboah J, McClelland RL, Polonsky TS, Burke GL, Sibley CT, O'Leary D, et al. Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA. 2012; 308:788-795 [S,I]
22910756             R/C
COMPARACIÓN DE LOS MARCADORES DE RIESGO NOVEDOSOS PARA MEJORAR LA VALORACIÓN DEL RIESGO CARDIOVASCULAR EN INDIVIDUOS DE RIESGO INTERMEDIO
 
Den Ruijter HM, Peters SA, Anderson TJ, Britton AR, Dekker JM, Eijkemans MJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012; 308:796-803 [M,II]
22910757             R/C
MEDIDAS DEL ESPESOR DE LA ÍNTIMA-MEDIA CAROTÍDEA PARA LA PREDICCIÓN DEL RIESGO CARDIOVASCULAR: METAANÁLISIS
 
Gaziano JM, Wilson PW. Cardiovascular risk assessment in the 21st century. JAMA. 2012; 308:816-817 [AO,I]
VALORACIÓN DEL RIESGO CARDIOVASCULAR EN EL SIGLO 21
 
REVISTA ESPAÑOLA DE CARDIOLOGIA
 
Ponikowski P, Jankowska EA. Anticoagulación para pacientes con insuficiencia cardiaca en ritmo sinusal: habitual en la práctica clínica, pero aún no basada en la evidencia. Rev Esp Cardiol. 2012; 65:687-689 [AO,I]
ANTICOAGULACIÓN PARA PACIENTES CON INSUFICIENCIA CARDIACA EN RITMO SINUSAL: HABITUAL EN LA PRÁCTICA CLÍNICA, PERO AÚN NO BASADA EN LA EVIDENCIA
 
Avellana P, Segovia J, Ferrero A, Vázquez R, Brugada J, Borrás X, et al. Tratamiento anticoagulante en pacientes con insuficiencia cardiaca por disfunción sistólica y ritmo sinusal: análisis del registro REDINSCOR. Rev Esp Cardiol. 2012; 65:705-712 [T,I]
22464104             R/C
TRATAMIENTO ANTICOAGULANTE EN PACIENTES CON INSUFICIENCIA CARDIACA POR DISFUNCIÓN SISTÓLICA Y RITMO SINUSAL: ANÁLISIS DEL REGISTRO REDINSCOR
 
Borrás X, Garcia-Moll X, Gómez-Doblas JJ, Zapata A, Artigas R; en representación de los investigadores del estudio AVANCE. Estudio de la angina estable en España y su impacto en la calidad de vida del paciente. Registro AVANCE. Rev Esp Cardiol. 2012; 65:734-741 [T,I]
22739550             R/C
ESTUDIO DE LA ANGINA ESTABLE EN ESPAÑA Y SU IMPACTO EN LA CALIDAD DE VIDA DEL PACIENTE. REGISTRO AVANCE
 
Moya-I-Mitjans A, Rivas-Gándara N, Sarrias-Mercè A, Pérez-Rodón J, Roca-Luque I. Síncope. Rev Esp Cardiol. 2012; 65:755-765 [R,I]
22763183             R/C
SÍNCOPE
 
THE LANCET
 
Prostate cancer: send away the PSA? Lancet. 2012; 380:307 [AO,II]
CÁNCER DE PRÓSTATA: ¿DESTERRAR EL PSA?
 
Das P, Horton R. The cultural challenge of HIV/AIDS. Lancet. 2012; 380:309-310 [AO,I]
EL RETO CULTURAL DEL VIH/SIDA
 
Hankey GJ. How effective is citicoline for acute ischaemic stroke? Lancet. 2012; 380:318-320 [AO,I]
¿CUÁN EFECTIVA ES LA CITICOLINA EN EL ICTUS ISQUÉMICO AGUDO?
 
Dávalos A, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Ferro J, Martínez-Vila E, et al; International Citicoline Trial on acUte Stroke (ICTUS) trial investigators. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet. 2012; 380:349-357 [EC,I]
22691567             R/C
CITICOLINA EN EL TRATAMIENTO DEL ICTUS ISQUÉMICO AGUDO: ESTUDIO INTERNACIONAL MULTICÉNTRICO ALEATORIZADO CONTROLADO CON PLACEBO (ENSAYO ICTUS)
 
Beyrer C, Baral SD, van Griensven F, Goodreau SM, Chariyalertsak S, Wirtz AL, et al. Global epidemiology of HIV infection in men who have sex with men. Lancet. 2012; 380:367-377 [R,I]
22819660             R/C
EPIDEMIOLOGÍA MUNDIAL DE LA INFECCIÓN POR VIH EN HOMBRES QUE PRACTICAN SEXO CON OTROS HOMBRES
 
Altman D, Aggleton P, Williams M, Kong T, Reddy V, Harrad D, et al. Men who have sex with men: stigma and discrimination. Lancet. 2012; 380:439-445 [R,I]
HOMBRES QUE PRACTICAN SEXO CON OTROS HOMBRES: ESTIGMA Y DISCRIMINACIÓN
 
Scheen AJ, Paquot N. Gliptin versus a sulphonylurea as add-on to metformin. Lancet. 2012; 380:450-452 [AO,I]
GLIPTINA FRENTE A SULFONILUREA COMO ADICIÓN A LA METFORMINA
 
Preventing hypertension: a hopeless dream? Lancet. 2012; 380:538 [AO,I]
PREVENIR LA HIPERTENSIÓN: ¿UN SUEÑO SIN ESPERANZA?
 
Psychological maltreatment of children: everyone's problem. Lancet. 2012; 380:538 [AO,I]
MALTRATO PSICOLÓGICO EN NIÑOS: PROBLEMA DE TODOS
 
Ebrahim S, Casas JP. Statins for all by the age of 50 years? Lancet. 2012; 380:545-547 [AO,I]
¿ESTATINAS PARA TODOS A LOS 50 AÑOS?
 
Mihaylova B, Emberson J, Blackwell L, Keech A, Simes J, Barnes EH, et al; Cholesterol Treatment Trialists' (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet. 2012; 380:581-590 [M,II]
22607822             R/C
EFECTOS DEL DESCENSO DE COLESTEROL LDL CON EL TRATAMIENTO CON ESTATINAS EN PERSONAS CON BAJO RIESGO DE ENFERMEDAD VASCULAR: METAANÁLISIS DE DATOS INDIVIDUALES DE 27 ENSAYOS ALEATORIZADOS
 
Ferrannini E, Cushman WC. Diabetes and hypertension: the bad companions. Lancet. 2012; 380:601-610 [R,I]
22883509             R/C
DIABETES E HIPERTENSIÓN: MALOS COMPAÑEROS
 
Giovino GA, Mirza SA, Samet JM, Gupta PC, Jarvis MJ, Bhala N, et al; GATS Collaborative Group. Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet. 2012; 380:668-679 [T,II]
22901888             R/C
USO DE TABACO EN 3.000 MILLONES DE INDIVIDUOS DE 16 PAÍSES: ANÁLISIS DE ENCUESTAS TRANSVERSALES DOMICILIARIAS NACIONALMENTE REPRESENTATIVAS
 
Gluten-free diets: vital or vogue? Lancet. 2012; 380:704 [AO,I]
22920739             R/C
DIETAS SIN GLUTEN: ¿ESENCIAL O MODA?
 
Zinkstok SM, Roos YB; ARTIS investigators. Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial. Lancet. 2012; 380:731-737 [EC,II]
22748820             R/C
ADMINISTRACIÓN PRECOZ DE ASPIRINA EN PACIENTES TRATADOS CON ALTEPLASA EN EL ICTUS ISQUÉMICO AGUDO: ENSAYO CONTROLADO ALEATORIZADO
 
THE NEW ENGLAND JOURNAL OF MEDICINE
 
Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al; Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 2012; 367:795-804 [S,I]
22784036             R/C
CAMBIOS CLÍNICOS Y EN BIOMARCADORES EN LA ENFERMEDAD DE ALZHEIMER HEREDADA DE FORMA DOMINANTE
 
Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al; Partners PrEP Study Team. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012; 367:399-410 [EC,I]
22784037             R/C
PROFILAXIS ANTIRRETROVÍRICA PARA LA PREVENCIÓN DEL VIH EN HOMBRES Y MUJERES HETEROSEXUALES
 
Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA; SPS3 Investigators. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012; 367:817-825 [EC,I]
22931315             R/C
EFECTOS DEL CLOPIDOGREL AÑADIDO A LA ASPIRINA EN PACIENTES CON ICTUS LACUNAR RECIENTE
 
Gandy S. Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease. N Engl J Med. 2012; 367:864-866 [AO,I]
MANEJO A LO LARGO DE LA VIDA DEL METABOLISMO BETA-AMILOIDE PARA PREVENIR LA ENFERMEDAD DE ALZHEIMER
 
Inzucchi SE. Diagnosis of diabetes. N Engl J Med. 2012; 367:542-550 [T,I]
DIAGNÓSTICO DE LA DIABETES
 
Cohen MS, Baden LR. Preexposure prophylaxis for HIV--where do we go from here? N Engl J Med. 2012; 367:459-461 [AO,I]
PROFILAXIS PREEXPOSICIÓN DEL VIH -- ¿A DÓNDE VAMOS DESDE AQUÍ?
 
Sox HC. Quality of life and guidelines for PSA screening. N Engl J Med. 2012; 367:669-671 [AO,I]
CALIDAD DE VIDA Y PAUTAS PARA EL CRIBAJE CON PSA
 
Heijnsdijk EA, Wever EM, Auvinen A, Hugosson J, Ciatto S, Nelen V, et al. Quality-of-life effects of prostate-specific antigen screening. N Engl J Med. 2012; 367:595-605 [T,I]
22894572             R/C
EFECTOS SOBRE LA CALIDAD DE VIDA DEL CRIBAJE CON PSA
 
Roehrig C, Turner A, Hughes-Cromwick P, Miller G. When the cost curve bent--pre-recession moderation in health care spending. N Engl J Med. 2012; 367:590-593 [AO,I]
CUANDO LA CURVA DEL COSTE SE INCLINÓ--MODERACIÓN PRERRECESIÓN EN LOS GASTOS DE LA ATENCIÓN SANITARIA
 
LaFerla FM. Preclinical success against Alzheimer's disease with an old drug. N Engl J Med. 2012; 367:570-572 [AO,I]
ÉXITO PRECLÍNICO CONTRA LA ENFERMEDAD DE ALZHEIMER CON UN VIEJO FÁRMACO
 
THORAX
 
Marchant J, Masters IB, Champion A, Petsky H, Chang AB. Randomised controlled trial of amoxycillin clavulanate in children with chronic wet cough. Thorax. 2012; 67:689-693 [EC,I]
22628120             R/C
ENSAYO CONTROLADO ALEATORIZADO DE AMOXICILINA-CLAVULÁNICO EN NIÑOS CON TOS HÚMEDA CRÓNICA
 
Tan WC, Vollmer WM, Lamprecht B, Mannino DM, Jithoo A, Nizankowska-Mogilnicka E, et al; for the BOLD Collaborative Research Group. Worldwide patterns of bronchodilator responsiveness: results from the Burden of Obstructive Lung Disease study. Thorax. 2012; 67:718-726 [T,I]
22544896             R/C
PAUTAS MUNDIALES DE RESPUESTA A BRONCODILATADORES: RESULTADOS DEL ESTUDIO CARGA DE ENFERMEDAD PULMONAR OBSTRUCTIVA
 
 
 
 
 
ACADEMIC MEDICINE
 
Findings suggest that positive mental health attenuates some adverse consequences of burnout. Medical student wellness programs should aspire to prevent burnout and promote mental health.
 
ANNALS OF INTERNAL MEDICINE
 
Validation of the LLP risk model in 3 independent external data sets demonstrated good discrimination and evidence of predicted benefits for stratifying patients for lung cancer CT screening. Further studies are needed to prospectively evaluate model performance and evaluate the optimal population risk thresholds for initiating lung cancer screening.
The USPSTF recommends exercise or physical therapy and vitamin D supplementation to prevent falls in community-dwelling adults aged 65 years or older who are at increased risk for falls. (Grade B recommendation)The USPSTF does not recommend automatically performing an in-depth multifactorial risk assessment in conjunction with comprehensive management of identified risks to prevent falls in community-dwelling adults aged 65 years or older because the likelihood of benefit is small. In determining whether this service is appropriate in individual cases, patients and clinicians should consider the balance of benefits and harms on the basis of the circumstances of prior falls, comorbid medical conditions, and patient values. (Grade C recommendation).
Colonoscopy-related factors are more important than polyp characteristics for stratification of colorectal cancer risk after colonoscopic polyp detection in the community setting.
Epidemiologic context and the number of cases of FRI that a physician had recently seen were associated with his or her likelihood to prescribe antimicrobials for FRI. Interventions that enhance a physician's contextual awareness may improve antimicrobial use.
 
ARCHIVES OF INTERNAL MEDICINE
 
Walking speed could be a simple measure to identify elderly adults who are most at risk for adverse outcomes related to high BP.
 
ARCHIVOS DE BRONCONEUMOLOGIA
 
Transcurridos 10 años desde la aparición de la primera estrategia GOLD (Global Strategy for the Diagnosis, Management, and Prevention of COPD) sobre la enfermedad pulmonar obstructiva crónica (EPOC), la nueva revisión publicada en la web de GOLD a finales del año 2011 supone un cambio significativo en lo que respecta al abordaje diagnóstico, evaluación clínica y planteamiento terapéutico de la enfermedad. En esta revisión se debaten no solo los aspectos más significativos que permanecen relativamente intactos sino también, y sobre todo, los que se han modificado de forma sustancial respecto a la revisión GOLD de 2006.
La valoración de la discapacidad en los pacientes con enfermedades respiratorias está regulada por el Ministerio de Trabajo y Asuntos Sociales, al igual que las discapacidades de cualquier otro sistema; sin embargo, creemos que su evaluación es especialmente complicada, ya que al tratarse de procesos crónicos, interrelacionan con otros sistemas y además en ocasiones cursan en brotes, por lo que pueden alternar períodos de normalidad con otros de limitación funcional importante.
El presente documento tiene su origen en la voluntad de la SEPAR de actualizar el tema y de dar respuesta a la solicitud de las asociaciones de pacientes con enfermedades respiratorias que así nos lo requirieron. En el mismo efectuamos un análisis de la situación actual, tanto de la legislación vigente en materia de incapacidad laboral, como de la determinación de los grados y porcentaje de discapacidad, así como de los criterios actualmente vigentes para la asignación de discapacidad atribuible a deficiencias del aparato respiratorio. Por último, se proponen unas líneas de trabajo que permitirían mejorar el escenario existente y delimitar esta valoración para patologías concretas.
 
ATENCION PRIMARIA
 
El primer artículo de esta serie sobre seguridad clínica lo dedicamos a la epidemiología y a las políticas preventivas de tipo sistémico. En la presente revisión nos centraremos en los errores médicos con especial énfasis en los errores de tipo diagnóstico. Estos errores derivan de las características a veces elusivas de la propia enfermedad, las circunstancias en que el paciente presenta sus síntomas, y las características del propio profesional. Si consideráramos al clínico como una «máquina de diagnóstico» -paradigma del «médico-robot»-, nos sería más fácil admitir unas limitaciones cognitivas, y poner en marcha estrategias institucionales que humanizarían el trato que en ocasiones recibe. De manera más concreta examinaremos 3 estrategias de mejora del razonamiento clínico: reconocimiento de situaciones peligrosas, metacognición y supervisor interno.
Evolución de la incidencia de la hemorragia digestiva alta en España en relación con el consumo de antiulcerosos
Se detecta un elevado incremento del consumo de fármacos antiulcerosos sin que tenga relación con la tendencia evolutiva de los ingresos por HDA.
La revisión sistemática de la medicación mejora la adecuación de uso del tratamiento antiagregante en ancianos polimedicados en alto riesgo vascular, sin afectar negativamente su calidad de vida. No se constatan mejoras en otras variables.
 
BRITISH JOURNAL OF PSYCHIATRY
 
Adjustment disorder shows a distinct profile as an intermediate category between no mental disorder and affective disorders (depression and anxiety disorders).
Clinicians may consider simple screening methods such as self-report tools rather than relying on unassisted clinical judgement but the added value of screening over and above clinical diagnosis remains unclear.
 
 
BRITISH MEDICAL JOURNAL
 
Published data assessing the risk of venous thromboembolism in women prescribed progestin-only contraception are limited. In this meta-analysis of eight observational studies, the use of progestin-only contraception was not associated with an increased risk of venous thromboembolism compared with non-users of hormonal contraception. The potential association between injectable progestins and thrombosis requires further study
The lack of a specific association and the discrepancy between findings of the analyses between and within people suggests that the interaction between proton pump inhibitors and clopidogrel is clinically unimportant.
The LiFE programme provides an alternative to traditional exercise to consider for fall prevention. Functional based exercise should be a focus for interventions to protect older, high risk people from falling and to improve and maintain functional capacity.
The multifaceted, semi-tailored intervention with counselling, education, and support for patients with mild Alzheimer's disease and their care givers did not have any significant effect beyond that with well structured follow-up support at 12 months after adjustment for multiple comparisons. The small positive effect found in the unadjusted primary outcome addressing depressive symptoms in patients may call for further research focusing on patients with Alzheimer's disease and comorbid depression.
No single vaccination strategy was most cost effective across countries. With aging populations, pre-existing immunity in particular could be of crucial importance for the cost effectiveness of options to mitigate a future influenza pandemic.
Physiotherapy has short term benefits in Parkinson's disease. A wide range of physiotherapy techniques are currently used to treat Parkinson's disease, with little difference in treatment effects. Large, well designed, randomised controlled trials with improved methodology and reporting are needed to assess the efficacy and cost effectiveness of physiotherapy for treating Parkinson's disease in the longer term.
The best evidence available points towards a putative protective role of ACE inhibitors but not ARBs in risk of pneumonia. Patient populations that may benefit most are those with previous stroke and Asian patients. ACE inhibitors were also associated with a decrease in pneumonia related mortality, but the data lacked strength.
Smoking cessation is associated with a mean increase of 4-5 kg in body weight after 12 months of abstinence, and most weight gain occurs within three months of quitting. Variation in weight change is large, with about 16% of quitters losing weight and 13% gaining more than 10 kg.
 
CANADIAN MEDICAL ASSOCIATION JOURNAL
 
Iron supplementation should be considered for women with unexplained fatigue who have ferritin levels below 50 μg/L. We suggest assessing the efficiency using blood markers after six weeks of treatment
Patients who presented with acute or persistent low-back pain improved markedly in the first six weeks. After that time improvement slowed. Low to moderate levels of pain and disability were still present at one year, especially in the cohorts with persistent pain.
 
DIABETES CARE
 
Modest levels of physical activity are associated with a lower risk of incident diabetes, compared with lower levels of activity.
Screening people with type 2 diabetes, who have not yet developed retinopathy, every 2 years, rather than annually, is a safe and cost-effective strategy. Our findings support those of other studies, and we therefore recommend a review of the current National Institute for Health and Clinical Excellence (NICE) guidelines for diabetic retinopathy screening implemented in the U.K.
Regular exercise reduces the risk of type 2 diabetes in overweight/obese individuals. Particularly, regular exercise and weight or waist circumference control are critical factors for preventing diabetes in overweight/obese individuals with IFG.
Our results seem to indicate that the A1C test criterion alone or in combination with fasting glucose test criterion does not provide a sensitive and specific diagnosis of abnormal carbohydrate metabolism in women who have had GDM.
 
DRUGS
 
Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with severe consequences, including symptoms, haemodynamic instability, increased cardiovascular mortality and stroke. While other arrhythmias such as torsades de pointes and sinus bradycardia are more typically thought of as drug induced, AF may also be precipitated by drug therapy, although ascribing causality to drug-associated AF is more difficult than with other drug-induced arrhythmias. Drug-induced AF is more likely to occur in patients with risk factors and co-morbidities that commonly co-exist with AF, such as advanced age, alcohol consumption, family history of AF, hypertension, thyroid dysfunction, sleep apnoea and heart disease. New-onset AF has been associated with cardiovascular drugs such as adenosine, dobutamine and milrinone. In addition, medications such as corticosteroids, ondansetron and antineoplastic agents such as paclitaxel, mitoxantrone and doxorubicin have been reported to induce AF. Whether bisphosphonate drugs are associated with new-onset AF remains controversial and requires further study. The potential contribution of specific drug therapy should be considered when patients present with new-onset AF.
The epidemiology of peptic ulcer disease (PUD) has undergone significant changes since the discovery of Helicobacter pylori. Various aetiologies contribute to recurrent PUD. Ulcers related to untreated H. pylori infection tend to recur. Use of NSAIDs, low-dose aspirin and dual anti-platelet therapy have become important risk factors for recurrent ulcers and their complications as the proportion of H. pylori-related ulcers declines. Recent data have shown that H. pylori-negative, NSAID-negative idiopathic peptic ulcers are on the rise and carry a higher risk of recurrent ulcer bleeding and mortality. Effective management of recurrent PUD relies on identification and modification of treatable risk factors. Persistent H. pylori infection should be carefully ruled out. Choice of an effective H. pylori eradication regimen should be based on local antibacterial resistance patterns. For patients who need long-term NSAID therapy, the initial choice of an NSAID relates to a patient's cardiovascular risk, and the need for therapy to decrease gastrointestinal (GI) complications is determined by the severity and number of GI risk factors. For patients on dual anti-platelet therapy, strategies to prevent recurrent ulcer disease and its complications centre on balancing the bleeding and thrombotic risks of individual patients. Long-term proton pump inhibitor maintenance therapy may be necessary to prevent recurrent ulcer bleeding for patients with ulcer bleeding from H. pylori-negative, NSAID-negative ulcers, and for patients who require NSAID or aspirin maintenance therapy.
Age-related hormonal decline is gradual and less recognized in men than in women. Symptoms are oftentimes ignored and non-specific. Fatigue, lack of concentration, mood swings, decreased sexual desire, erectile dysfunction, infertility, hair loss, reduced muscle and bone mass, and weight gain are a few of the symptoms of male hypogonadism. This disorder is linked to reduction in quality of life, and poorer health outcomes as it may increase the risk for cardiovascular disease, diabetes mellitus, metabolic syndrome, Alzheimer's disease and premature death. Different modalities of testosterone replacement therapy have evolved over 70 years, and sales continue to grow. Each preparation is differentiated by route of delivery, ease of use, cost and pharmacokinetics. Topical/transdermal testosterone replacement therapy, including patches and gels, are the most modern formulations on the market. These are more expensive treatments, but yield more physiological concentrations of testosterone. Restoration of testosterone levels to the eugonadal range reverses signs and symptoms of hypogonadism, except for infertility, and may alleviate co-morbidities associated with hypogonadism. Patient understanding of and compliance with both treatment and monitoring are of utmost importance to achieve clinical success with maximum benefit and minimum risk. The aim of our review is to summarize the indications, contraindications, benefits and risks of testosterone replacement therapy as they relate to transdermal administration. Further, we compare the various testosterone preparations, focusing on the newest topical/transdermal routes of administration that are currently available.
Subcutaneous exenatide extended-release (ER; Bydureon™; also known as exenatide once weekly), a glucagon-like peptide-1 receptor agonist, provides a convenient, simple, once-weekly regimen that is approved in adult patients with type 2 diabetes as adjunctive monotherapy to diet plus exercise (in the US; not as first-line therapy) and/or as combination therapy with specific oral antihyperglycaemic drugs (OADs) in patients with inadequately controlled type 2 diabetes despite treatment with these OADs (US and Europe). This article reviews the clinical efficacy and tolerability of exenatide ER in the treatment of adult patients with type 2 diabetes and gives a brief overview of its pharmacological properties. In several short-term (24-30 weeks) well designed trials, adjunctive subcutaneously injectable exenatide ER once weekly, as monotherapy or in combination with OADs, significantly improved glycaemic control, bodyweight and some surrogate markers of cardiovascular risk in adult patients with inadequately controlled type 2 diabetes despite diet and exercise and/or treatment with OADs. Furthermore, the beneficial effects of adjunctive exenatide ER therapy were sustained in extension studies of up to 3 years of treatment. Overall, the intensity of glycaemic control with exenatide ER was generally better than that observed with the exenatide immediate-release formulation (twice daily), sitagliptin or insulin glargine. Exenatide ER was shown to be noninferior to metformin in terms of glycaemic efficacy, but did not meet the criteria for noninferiority versus liraglutide. In treatment-naive patients, exenatide ER treatment did not meet noninferiority criteria versus pioglitazone, whereas in treatment-experienced patients, exenatide ER provided better glycaemic control than pioglitazone. Improvements in glycaemic control with exenatide ER and, in general, with other antihyperglycaemic agents were reflected in significant improvements from baseline in treatment satisfaction and health-related quality-of-life measures. Exenatide ER was generally well tolerated in patients participating in these trials, with most treatment-emergent adverse events being of a gastrointestinal nature, of mild to moderate severity, transient and of a similar nature and incidence to those occurring with the exenatide immediate-release formulation. Thus, exenatide ER is a useful option for the treatment of type 2 diabetes, particularly in patients where bodyweight loss is an essential aspect of the individual patient's management.
 
EUROPEAN HEART JOURNAL
 
Whereas safety measures appear to have limited serious cardiovascular consequences of COX-2 inhibitors, the risk of developing atrial fibrillation may have been overlooked and may necessitate consideration and precautions.
 
FAMILY PRACTICE
 
AOBP virtually eliminated office-induced hypertension. The decrease in MOBP was attributed to participation in a research study and not to any specific intervention.
Cognitive impairment is probably underdiagnosed in primary care. The combination of the FAQ and the MMS had excellent performance for dementia detection; however, no satisfactory instrument or instrument combination could be found for cognitive impairment.
The evidence for the benefits of POC CRP measurement in LRTI patients in primary care is limited, contradictory and does not support its use to guide treatment decisions yet.
Although the most common cause of jaundice is bile duct stones, cancers are present in over a quarter of patients with jaundice in this study, demonstrating the importance of urgent investigation into the underlying cause.
Depressive symptoms were more common in Russia than in Korea and USA but had less impact on daily functioning. Cultural or environmental factors may account for this finding.
Many Canadian seniors have an elevated risk of adverse events due to taking a high number of prescription medications and not having the potential side effects and drug interactions explained to them. There are interventions that can potentially reduce polypharmacy and adverse events, including routine medication reviews.
 
GUT
 
In routine practice, the risk of colorectal cancer after adenoma removal remains high and depends both on initial adenoma features and on colonoscopy surveillance practices. Gastroenterologists should encourage patients to comply with long-term colonoscopic surveillance.
When assuming a suboptimal efficacy of endoscopy in preventing CRC, the addition of low-dose aspirin may be an effective and cost-effective strategy, mainly because of its high efficacy in preventing proximal CRC.
 
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
 
The addition of common CIMT measurements to the Framingham Risk Score was associated with small improvement in 10-year risk prediction of first-time myocardial infarction or stroke, but this improvement is unlikely to be of clinical importance.
Coronary artery calcium, ankle-brachial index, high-sensitivity CRP, and family history were independent predictors of incident CHD/CVD in intermediate-risk individuals. Coronary artery calcium provided superior discrimination and risk reclassification compared with other risk markers.
Among women receiving care in primary care clinics, providing a partner violence resource list with or without screening did not result in improved health.
Compared with guideline-based usual care, exercise training resulted in a modest reduction in depressive symptoms, although the clinical significance of this improvement is unknown.
 
REVISTA ESPAÑOLA DE CARDIOLOGIA
 
En una serie amplia y contemporánea de pacientes de nuestro medio con insuficiencia cardiaca, fracción de eyección del ventrículo izquierdo =35% y ritmo sinusal, un 26% recibían anticoagulación. Ello no se asoció a menor mortalidad ni incidencia de ictus aunque se observó una reducción de una combinación de eventos cardiacos mayores.
Persiste una elevada proporción de pacientes sintomáticos y con reducción de la calidad de vida. La percepción del paciente sobre la enfermedad es peor que la del médico.
El tratamiento de la cardiopatía isquémica estable ha evolucionado durante la última década. Los FRCV se controlan mejor, se realiza más revascularización coronaria y han aparecido nuevas medicaciones. A pesar de ello, persiste una elevada proporción de pacientes sintomáticos. La percepción de la enfermedad es diferente entre pacientes y médicos: en general, los médicos perciben la enfermedad menos grave y menos invalidante que la percibida por los propios pacientes. Además, la satisfacción del paciente con el tratamiento antianginoso se mantiene muy similar a la de estudios publicados hace 9 años.
 
THE LANCET
 
The results of this long-term randomised active-controlled trial advance the clinical evidence and comparative effectiveness bases for treatment options available to patients with type 2 diabetes mellitus. The findings could improve decision making for clinical treatment when metformin alone is insufficient.
In the JUPITER primary prevention trial, the cardiovascular and mortality benefits of statin therapy exceed the diabetes hazard, including in participants at high risk of developing diabetes.
High blood pressure is reported in over two-thirds of patients with type 2 diabetes, and its development coincides with the development of hyperglycaemia. Many pathophysiological mechanisms underlie this association. Of these mechanisms, insulin resistance in the nitric-oxide pathway; the stimulatory effect of hyperinsulinaemia on sympathetic drive, smooth muscle growth, and sodium-fluid retention; and the excitatory effect of hyperglycaemia on the renin-angiotensin-aldosterone system seem to be plausible. In patients with diabetes, hypertension confers an enhanced risk of cardiovascular disease. A blood pressure of lower than 140/85 mm Hg is a reasonable therapeutic goal in patients with type 2 diabetes according to clinical trial evidence. People with controlled diabetes have a similar cardiovascular risk to patients without diabetes but with hypertension. A renin-angiotensin system blocker combined with a thiazide-type diuretic might be the best initial antihypertensive regimen for most people with diabetes. In general, the positive effects of antihypertensive drugs on cardiovascular outcomes outweigh the negative effects of antihypertensive drugs on glucose metabolism.
Under the circumstances of the ICTUS trial, citicoline is not efficacious in the treatment of moderate-to-severe acute ischaemic stroke.
Early administration of intravenous aspirin in patients with acute ischaemic stroke treated with alteplase does not improve outcome at 3 months and increases the risk of SICH. The results of this trial do not support a change of the current guidelines, which advise to start antiplatelet therapy 24 h after alteplase.
Epidemics of HIV in men who have sex with men (MSM) continue to expand in most countries. We sought to understand the epidemiological drivers of the global epidemic in MSM and why it continues unabated. We did a comprehensive review of available data for HIV prevalence, incidence, risk factors, and the molecular epidemiology of HIV in MSM from 2007 to 2011, and modelled the dynamics of HIV transmission with an agent-based simulation. Our findings show that the high probability of transmission per act through receptive anal intercourse has a central role in explaining the disproportionate disease burden in MSM. HIV can be transmitted through large MSM networks at great speed. Molecular epidemiological data show substantial clustering of HIV infections in MSM networks, and higher rates of dual-variant and multiple-variant HIV infection in MSM than in heterosexual people in the same populations. Prevention strategies that lower biological transmission and acquisition risks, such as approaches based on antiretrovirals, offer promise for controlling the expanding epidemic in MSM, but their potential effectiveness is limited by structural factors that contribute to low health-seeking behaviours in populations of MSM in many parts of the world.
Although the public prominence of coeliac disease has increased, people who are unaware of their sensitivity to gluten can suffer for years from poorly defined but debilitating symptoms. In a recent study in the American Journal of Gastroenterology by James Everhart and colleagues, results from a nationally representative survey of about 7800 people indicated that the prevalence of coeliac disease in the USA is as high as 0·71% (one in 141)—a burden that seems to fall largely among white non-Hispanic people.
Although the public prominence of coeliac disease has increased, people who are unaware of their sensitivity to gluten can suffer for years from poorly defined but debilitating symptoms. In a recent study in the American Journal of Gastroenterology by James Everhart and colleagues, results from a nationally representative survey of about 7800 people indicated that the prevalence of coeliac disease in the USA is as high as 0·71% (one in 141)—a burden that seems to fall largely among white non-Hispanic people.
So far, the only treatment for coeliac disease is a strict and lifelong gluten-free diet, which involves avoiding foods containing wheat, rye, and barley. Patients' compliance is important, but challenging, given the ubiquity of gluten in processed foods. Despite the practical complications, an estimated 1·6 million USA citizens choose to abstain from gluten. Most of these do not have coeliac disease, but make this lifestyle choice for other perceived health benefits.
The irony of many coeliac patients not knowing their diagnosis, while millions of non-sufferers banish gluten from their lives, is a public health farce. The American Journal of Gastroenterology paper highlights the need for greater public awareness of the symptoms of coeliac disease. More research is also needed into the systemic effects of gluten abstinence in healthy people, and for the development of non-dietary treatments for coeliac disease.
In individuals with 5-year risk of major vascular events lower than 10%, each 1 mmol/L reduction in LDL cholesterol produced an absolute reduction in major vascular events of about 11 per 1000 over 5 years. This benefit greatly exceeds any known hazards of statin therapy. Under present guidelines, such individuals would not typically be regarded as suitable for LDL-lowering statin therapy. The present report suggests, therefore, that these guidelines might need to be reconsidered.
The first wave of GATS showed high rates of smoking in men, early initiation of smoking in women, and low quit ratios, reinforcing the view that efforts to prevent initiation and promote cessation of tobacco use are needed to reduce associated morbidity and mortality.
 
 
 
THE NEW ENGLAND JOURNAL OF MEDICINE
 
We found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment. Our results require confirmation with the use of longitudinal data and may not apply to patients with sporadic Alzheimer's disease.
Oral TDF and TDF-FTC both protect against HIV-1 infection in heterosexual men and women.
Among patients with recent lacunar strokes, the addition of clopidogrel to aspirin did not significantly reduce the risk of recurrent stroke and did significantly increase the risk of bleeding and death.
The benefit of PSA screening was diminished by loss of QALYs owing to postdiagnosis long-term effects. Longer follow-up data from both the ERSPC and quality-of-life analyses are essential before universal recommendations regarding screening can be made. (Funded by the Netherlands Organization for Health Research and Development and others.).
 
THORAX
 
A 2-week course of amoxycillin clavulanate will achieve cough resolution in a significant number of children with chronic wet cough. BAL data support the diagnosis of PBB in the majority of these children
The results provide reference values for bronchodilator responses worldwide that confirm guideline estimates for a clinically significant level of BDR in bronchodilator testing.
 
 
 

                      

 

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