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Abril 2013 PDF Imprimir E-mail
Lunes, 06 de Mayo de 2013 00:00

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SELECCIÓN DE REFERENCIAS BIBLIOGRÁFICAS DE LO PUBLICADO EN RELACIÓN CON ATENCIÓN PRIMARIA

Selección realizada por Antonio Manteca González

Durning SJ, Artino AR Jr, Schuwirth L, van der Vleuten C. Clarifying assumptions to enhance our understanding and assessment of clinical reasoning. Acad Med. 2013; 88:442-448 [R,I]
23425980             R/C
CLARIFICAR LOS SUPUESTOS PARA REFORZAR NUESTRA COMPRENSIÓN Y VALORACIÓN DEL RAZONAMIENTO CLÍNICO

Welty LJ, Carter RE, Finkelstein DM, Harrell FE Jr, Lindsell CJ, Macaluso M, et al; on behalf of the Biostatistics, Epidemiology, and Research Design Key Function Committee of the Clinical and Translational Science Award Consortium. Strategies for developing biostatistics resources in an academic health center. Acad Med. 2013; 88:454-460 [R,I]

23425984             R/C

ESTRATEGIAS PARA DESARROLLAR RECURSOS ESTADÍSTICOS EN UN CENTRO DE SALUD DOCENTE

 

Jolly P, Erikson C, Garrison G. U.S. Graduate medical education and physician specialty choice. Acad Med. 2013; 88:468-474 [T,I]

23425979             R/C

FORMACIÓN MÉDICA DE PREGRADO Y ELECCIÓN DE LA ESPECIALIDAD MÉDICA

 

Zhang H, Plutzky J, Skentzos S, Morrison F, Mar P, Shubina M, et al. Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med. 2013; 158:526-534 [S,I]
23546564             R/C
INTERRUPCIÓN DE LAS ESTATINAS EN LOS PUNTOS DE ATENCIÓN HABITUALES: ESTUDIO DE COHORTES

Fink HA, Wilt TJ, Eidman KE, Garimella PS, MacDonald R, Rutks IR, et al. Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians clinical guideline. Ann Intern Med. 2013; 158:535-543 [M,II]

23546565             R/C

TRATAMIENTO MÉDICO PARA PREVENIR LA NEFROLITIASIS RECURRENTE EN LOS ADULTOS: REVISIÓN SISTEMÁTICA PARA UNA GUÍA DE PRÁCTICA DEL AMERICAN COLLEGE OF PHYSICIANS

 

Weiner SJ, Schwartz A, Sharma G, Binns-Calvey A, Ashley N, Kelly B, et al. Patient-centered decision making and health care outcomes: an observational study. Ann Intern Med. 2013; 158:573-579 [T,I]

23588745             R/C

TOMA DE DECISIONES CENTRADA EN EL PACIENTE Y RESULTADOS DE LA ATENCIÓN CLÍNICA: ESTUDIO OBSERVACIONAL

 

Fenton JJ, Xing G, Elmore JG, Bang H, Chen SL, Lindfors KK, et al. Short-term outcomes of screening mammography using computer-aided detection: a population-based study of Medicare enrollees. Ann Intern Med. 2013; 158:580-587 [S,I]

23588746             R/C

RESULTADOS A CORTO PLAZO DEL CRIBAJE MAMOGRÁFICO USANDO DETECCIÓN AYUDADA POR ORDENADOR: ESTUDIO POBLACIONAL DE LOS INSCRITOS EN MEDICARE

 

Pickhardt PJ, Pooler BD, Lauder T, Del Rio AM, Bruce RJ, Binkley N. Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications. Ann Intern Med. 2013; 158:588-595 [T,I]

23588747             R/C

CRIBAJE OPORTUNÍSTICO DE LA OSTEOPOROSIS USANDO TAC ABDOMINALES OBTENIDOS POR OTRAS INDICACIONES

 

Tangri N, Kitsios GD, Inker LA, Griffith J, Naimark DM, Walker S, et al. Risk prediction models for patients with chronic kidney disease: a systematic review. Ann Intern Med. 2013; 158:596-603 [M,II]

23588748             R/C

MODELOS DE PREDICCIÓN DE RIESGO EN PACIENTES CON ENFERMEDAD RENAL CRÓNICA: REVISIÓN SISTEMÁTICA

 

Nelson HD, Smith ME, Griffin JC, Fu R. Use of medications to reduce risk for primary breast cancer: a systematic review for the U.S. Preventive services task force. Ann Intern Med. 2013; 158:604-614 [M,II]

23588749             R/C

USO DE MEDICACIÓN PARA REDUCIR EL RIESGO DE CÁNCER DE MAMA PRIMARIO: REVISIÓN SITEMÁTICA PARA EL U.S. Preventive services task force

 

Ruano-Ravina A, Pérez M, Fernández-Villar A. Cribado de cáncer de pulmón con tomografía computarizada de baja dosis después del National Lung Screening Trial. El debate continúa abierto. Arch Bronconeumol. 2013; 49:158-165 [R,II]
23317766             R/C
CRIBADO DE CÁNCER DE PULMÓN CON TOMOGRAFÍA COMPUTARIZADA DE BAJA DOSIS DESPUÉS DEL NATIONAL LUNG SCREENING TRIAL. EL DEBATE CONTINÚA ABIERTO

 

Aragonès E, Caballero A, Piñol JL. El modelo INDI (INterventions for Depression Improvement). Una propuesta eficaz para mejorar los resultados clínicos de la depresión en atención primaria. Aten Primaria. 2013;45:179-180 [AO,I]
23473632
UNA PROPUESTA EFICAZ PARA MEJORAR LOS RESULTADOS CLÍNICOS DE LA DEPRESIÓN EN ATENCIÓN PRIMARIA

Martín I. Abordaje integral del paciente pluripatológico en atención primaria. Tendencia necesitada de hechos. Aten Primaria. 2013; 45:181-183 [AO,I]

23433703

ABORDAJE INTEGRAL DEL PACIENTE PLURIPATOLÓGICO EN ATENCIÓN PRIMARIA. TENDENCIA NECESITADA DE HECHOS

 

Ballesteros S. Análisis inadecuados de los desfibriladores externos semiautomáticos durante la parada cardiorrespiratoria extrahospitalaria. Aten Primaria. 2013; 45:193-198 [T,I]

23265845             R/C

ANÁLISIS INADECUADOS DE LOS DESFIBRILADORES EXTERNOS SEMIAUTOMÁTICOS DURANTE LA PARADA CARDIORRESPIRATORIA EXTRAHOSPITALARIA

 

Domínguez JM, Padilla I, Domínguez J, Domínguez M. Tipologías comportamentales en relación con el burnout, mobbing, personalidad, autoconcepto y adaptación de conducta en trabajadores sanitarios. Aten Primaria. 2013; 45:199-207 [T,I]

23274059             R/C

TIPOLOGÍAS COMPORTAMENTALES EN RELACIÓN CON EL BURNOUT, MOBBING, PERSONALIDAD, AUTOCONCEPTO Y ADAPTACIÓN DE CONDUCTA EN TRABAJADORES SANITARIOS

 

Robles P, de Frutos E, Moreno N, Mas A, Sánchez A, Morató ML. Me voy al dentista: ¿antibiótico como prevención o como tratamiento? Aten Primaria. 2013; 45:216-221 [R,I]

23182318             R/C

ME VOY AL DENTISTA: ¿ANTIBIÓTICO COMO PREVENCIÓN O COMO TRATAMIENTO?

 

Pilling S, Gould N, Whittington C, Taylor C, Scott S; Guideline Development Group. Recognition, intervention, and management of antisocial behaviour and conduct disorders in children and young people: summary of NICE-SCIE guidance. BMJ. 2013; 346:f1298 [M,II]
23535256
RECONOCIMIENTO, INTERVENCIÓN Y MANEJO DEL COMPORTAMIENTO ANTISOCIAL Y LOS TRASTORNOS DE CONDUCTA EN NIÑOS Y JÓVENES: RESUMEN DE LA GUÍA NICE-SCIE

He FJ, Li J, Macgregor GA. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. BMJ. 2013; 346:f1325 [M,II]

23558162             R/C

EFECTO SOBRE LA PRESIÓN SANGUÍNEA DE UNA REDUCCIÓN MODESTA DE SAL A LARGO PLAZO: REVISIÓN SISTEMÁTICA COCHRANE Y METAANÁLISIS DE ENSAYOS ALEATORIZADOS

 

Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ. Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ. 2013; 346:f1326 [M,II]

23558163             R/C

EFECTO SOBRE LA SALUD DE UNA MENOR INGESTA DE SODIO: REVISIÓN SISTEMÁTICA Y METAANÁLISIS

 

Baldassarre RL, Hughes TH. Investigating suspected scaphoid fracture. BMJ. 2013; 346:f1370 [R,I]

23535257

INVESTIGAR LA SOSPECHA DE FRACTURA DE ESCAFOIDES

 

Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ. 2013; 346:f1378 [M,II]

23558164             R/C

EFECTO DE UN AUMENTO DE LA INGESTA DE POTASIO SOBRE LOS FACTORES DE RIESGO CARDIOVASCULAR Y LA ENFERMEDAD: REVISIÓN SISTEMÁTICA Y METAANÁLISIS

 

Franco M, Bilal U, Orduñez P, Benet M, Morejón A, Caballero B, et al. Population-wide weight loss and regain in relation to diabetes burden and cardiovascular mortality in Cuba 1980-2010: repeated cross sectional surveys and ecological comparison of secular trends. BMJ. 2013; 346:f1515 [T,I]

23571838             R/C

PÉRDIDA Y RECUPERACIÓN DE PESO POBLACIONALES EN RELACIÓN CON LA CARGA DE DIABETES Y LA MORTALIDAD CARDIOVASCULAR EN CUBA 1980-2010: ENCUESTAS TRANSVERSALES REPETIDAS Y COMPARACIÓN ECOLÓGICA DE LAS TENDENCIAS SECULARES

 

Kramer CK, Zinman B, Gross JL, Canani LH, Rodrigues TC, Azevedo MJ, et al. Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis. BMJ. 2013; 346:f1654 [M,II]

23529983             R/C

PREDICCIÓN DE LA MORTALIDAD POR CUALQUIER CAUSA Y DE LOS ACONTECIMIENTOS CARDIOVASCULARES MEDIANTE PREDICCIÓN POR TABLAS DE CALCIO ARTERIAL CORONARIO EN PERSONAS CON DIABETES TIPO 2: REVISIÓN SISTEMÁTICA Y METAANÁLISIS

 

Nijman RG, Vergouwe Y, Thompson M, van Veen M, van Meurs AH, van der Lei J, et al. Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study. BMJ 2013; 346:f1706 [T,I]

23550046             R/C

MODELO DE PREDICCIÓN CLÍNICA PARA AYUDAR A LOS MÉDICOS DE URGENCIAS EN EL MANEJO DE LOS NIÑOS CON FIEBRE CON RIESGO DE INFECCIONES BACTERIANAS GRAVES: ESTUDIO DIAGNÓSTICO

 

Willett WC. Weight changes and health in Cuba. BMJ. 2013; 346:f1777 [AO,I]

23571839

CAMBIOS DE PESO Y SALUD EN CUBA

 

Vale CL, Tierney JF, Burdett S. Can trial quality be reliably assessed from published reports of cancer trials: evaluation of risk of bias assessments in systematic reviews. BMJ. 2013; 346:f1798 [M,II]

23610376             R/C

¿SE PUEDE CONFIAR EN LA CALIDAD DEL ENSAYO VALORANDO LOS INFORMES PUBLICADOS DE ENSAYOS DE CÁNCER? EVALUACIÓN DE LAS VALORACIONES DEL RIESGO DE SESGO EN LAS REVISIONES SISTEMÁTICAS

 

Bell KJ, Hayen A, Irwig L, Takahashi O, Ohde S, Glasziou P. When to remeasure cardiovascular risk in untreated people at low and intermediate risk: observational study. BMJ. 2013; 346:f1895 [T,I]

23553971             R/C

CUÁNDO VOLVER A MEDIR EL RIESGO CARDIOVASCULAR EN PERSONAS DE RIESGO BAJO E INTERMEDIO NO TRATADAS: ESTUDIO OBSERVACIONAL

 

Raaschou P, Simard JF, Holmqvist M, Askling J; ARTIS Study Group. Rheumatoid arthritis, anti-tumour necrosis factor therapy, and risk of malignant melanoma: nationwide population based prospective cohort study from Sweden. BMJ. 2013; 346:f1939 [S,I]

23568792             R/C

ARTRITIS REUMATOIDE, TRATAMIENTO CON FACTOR DE NECROSIS TUMORAL Y RIESGO DE MELANOMA MALIGNO: ESTUDIO DE COHORTE NACIONAL DE POBLACIÓN PROSPECTIVO EN SUECIA

 

Vidal EI, Villas Boas PJ, Valle AP, Cerqueira AT, Fukushima FB. Delirium in older adults. BMJ. 2013; 346:f2031 [R,I]

23571740

SÍNDROME CONFUSIONAL EN ANCIANOS

 

Rai D, Lee BK, Dalman C, Golding J, Lewis G, Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ. 2013; 346:f2059 [CC,I]

23604083             R/C

DEPRESIÓN EN LOS PADRES, USO DE ANTIDEPRESIVOS EN LA MADRE DURANTE EL EMBARAZO Y RIESGO DE TRASTORNOS DEL ESPECTRO DEL AUTISMO: ESTUDIO DE CASO CONTROL POBLACIONAL

 

Collier F, Smith RC, Morton CA. Diagnosis and management of hidradenitis suppurativa. BMJ. 2013; 346:f2121 [R,I]

23613539

DIAGNÓSTICO Y MANEJO DE LA HIDROSADENITIS SUPURADA

 

Strazzullo P. Reducing sodium and increasing potassium intake. BMJ. 2013; 346:f2195 [AO,I]

23572093

REDUCIR LA INGESTA DE SODIO Y AUMENTAR LA DE POTASIO

 

Schroll JB, Bero L, Gøtzsche PC. Searching for unpublished data for Cochrane reviews: cross sectional study. BMJ. 2013; 346:f2231 [T,I]

23613540             R/C

BÚSQUEDA DE DATOS NO PUBLICADOS EN LAS REVISIONES COCHRANE: ESTUDIO TRANSVERSAL

 

McCulloch P. Surgery or drugs for gastro-oesophageal reflux? BMJ. 2013; 346:f2263 [AO,I]

23599319

¿CIRUGÍA O FÁRMACOS EN EL REFLUJO GASTROESOFÁGICO?

 

Eurich DT, Simpson S, Senthilselvan A, Asche CV, Sandhu-Minhas JK, McAlister FA. Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study. BMJ. 2013; 346:f2267 [S,II]

23618722             R/C

SEGURIDAD Y EFECTIVIDAD COMPARADAS DE LA SITAGLIPTINA EN PACIENTES CON DIABETES TIPO 2: ESTUDIO DE COHORTE POBLACIONAL RETROSPECTIVO

 

Dechartres A, Trinquart L, Boutron I, Ravaud P. Influence of trial sample size on treatment effect estimates: meta-epidemiological study. BMJ. 2013; 346:f2304 [M,II]

23616031             R/C

INFLUENCIA DEL TAMAÑO MUESTRAL DEL ENSAYO SOBRE LA ESTIMACIÓN DEL EFECTO DEL TRATAMIENTO: ESTUDIO METAEPIDEMIOLÓGICO

 

Ball HL. Supporting parents who are worried about their newborn's sleep. BMJ. 2013; 346:f2344 [AO,I]

23587748

DAR APOYO A LOS PADRES PREOCUPADOS POR EL SUEÑO DEL RECIÉN NACIDO

 

Kotecha T, Fox K. Investigating suspected heart failure. BMJ. 2013; 346:f2442 [R,I]

23616032

INVESTIGAR LA SOSPECHA DE INSUFICIENCIA CARDIACA

 

Edmiston R, Mitchell C. Hearing loss in adults. BMJ. 2013; 346:f2496 [R,I]

23618723

PÉRDIDA DE AUDICIÓN EN ADULTOS

 

Altaf F, Gibson A, Dannawi Z, Noordeen H. Adolescent idiopathic scoliosis. BMJ. 2013; 346:f2508 [R,I]

23633006

ESCOLIOSIS IDIOPÁTICA DEL ADOLESCENTE

 

Chinthapalli K. NICE is dead; long live NICE. BMJ. 2013; 346:f2546 [AO.I]

23615594

NICE HA MUERTO; VIVA NICE

 

Blackhall LJ. Do patients need to know they are terminally ill? No. BMJ. 2013; 346:f2560 [AO,I]

23615595

¿NECESITAN SABER LOS PACIENTES QUE ESTÁN EN SITUACIÓN TERMINAL? NO

 

Collis E, Sleeman KE. Do patients need to know they are terminally ill? Yes. BMJ. 2013; 346:f2589 [AO,I]

23615596

¿NECESITAN SABER LOS PACIENTES QUE ESTÁN EN SITUACIÓN TERMINAL?

 

McLaren LA, Quinn TJ, McKay GA. Diabetes control in older people. BMJ. 2013; 346:f2625 [AO,I]

23615598

CONTROL DE LA DIABETES EN PERSONAS ANCIANAS

 

Godlee F. Helping patients to die well. BMJ. 2013; 346:f2656

[AO,I]

AYUDAR A MORIR BIEN A LOS PACIENTES

 

Harder B. Are MOOCs the future of medical education? BMJ. 2013; 346:f2666 [AO,I]

¿SON LOS MOOC (MASSIVE OPEN ONLINE COURSES) EL FUTURO DE LA FORMACIÓN MÉDICA?

 

Sedgwick P. Statistical Question. Correlation versus linear regression. BMJ. 2013; 346:f2686 [R,I]

PREGUNTA ESTADÍSTICA. CORRELACIÓN FRENTE A REGRESIÓN LINEAL

 

Lewis SP, Heath NL. Nonsuicidal self-injury. CMAJ. 2013; 185:505 [AO,I]
23228994
AUTOLESIÓN NO SUICIDA

Liu B. Is transdermal menopausal hormone therapy a safer option than oral therapy? CMAJ. 2013; 185:549-550 [AO,I]

23509132

¿ES UNA OPCIÓN MÁS SEGURA LA TERAPIA HORMONAL MENOPÁUSICA TRANSDÉRMICA QUE LA ORAL?

 

Racine A, Bijon A, Fournier A, Mesrine S, Clavel-Chapelon F, Carbonnel F, et al. Menopausal hormone therapy and risk of cholecystectomy: a prospective study based on the French E3N cohort. CMAJ. 2013; 185:555-561 [S,I]

23509128             R/C

TERAPIA HORMONAL MENOPÁUSICA Y RIESGO DE COLECISTECTOMÍA: ESTUDIO PROSPECTIVO BASADO EN LA COHORTE FRANCESA E3N

 

Allen RH, Cwiak CA, Kaunitz AM. Contraception in women over 40 years of age. CMAJ. 2013; 185:565-573 [R,I]

23460635

ANTICONCEPCIÓN EN MUJERES DE MÁS DE 40 AÑOS DE EDAD

 

Olah ME, Gaisano G, Hwang SW. The effect of socioeconomic status on access to primary care: an audit study. CMAJ. 2013; 185:E263-E269 [T,II]

23439620             R/C

EFECTO DEL ESTATUS SOCIOECONÓMICO SOBRE EL ACCESO A LA ATENCIÓN PRIMARIA: ESTUDIO DE AUDITORÍA

 

Chretien KC, Kind T. Social media and clinical care: ethical, professional, and social implications. Circulation. 2013; 127:1413-1421 [R,I]
23547180
LOS MEDIOS SOCIALES Y LA ATENCIÓN CLÍNICA: IMPLICACIONES ÉTICAS, PROFESIONALES Y SOCIALES

Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, et al. Management of patients with peripheral artery disease (Compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013; 127:1425-1443 [M,II]

23457117

MANEJO DE PACIENTES CON ENFERMEDAD ARTERIAL PERIFÉRICA (COMPILACIÓN DE LAS RECOMENDACIONES DE LA GUÍA 2005 A 2011 DE LA ACCF/AHA): INFORME DEL GRUPO DE TRABAJO DE GUÍAS DE PRÁCTICA CLÍNICA DE LA ACCF/AHA

 

Mandawat A, Curtis JP, Mandawat A, Njike VY, Lampert R. Safety of pacemaker implantation in nonagenarians: an analysis of the healthcare cost and utilization project-nationwide inpatient sample. Circulation. 2013; 127:1453-1465 [T,I]

23513066             R/C

SEGURIDAD DE LA IMPLANTACIÓN DE MARCAPASOS EN NONAGENARIOS: ANÁLISIS DEL PROYECTO DE UTILIZACIÓN Y COSTES SANITARIOS--MUESTRA DE PACIENTES DE ÁMBITO NACIONAL

 

Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, et al; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group. The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008. Circulation. 2013; 127:1493-1502 [S,II]

23481623             R/C

TRANSICIÓN MUNDIAL DEL RIESGO CARDIOVASCULAR: ASOCIACIÓN DE CUATRO FACTORES DE RIESGO METABÓLICOS CON RENTA NACIONAL, URBANIZACIÓN Y DIETA OCCIDENTAL EN 1980 Y 2008

 

Lilly LS. Treatment of acute and recurrent idiopathic pericarditis. Circulation. 2013; 127:1723-1726 [R,I]

23609551

TRATAMIENTO DE LA PERICARDITIS IDIOPÁTICA AGUDA Y RECURRENTE

 

Pearson TA, Palaniappan LP, Artinian NT, Carnethon MR, Criqui MH, Daniels SR, et al; American Heart Association Council on Epidemiology and Prevention. American Heart Association guide for improving cardiovascular health at the community level, 2013 update: a scientific statement for public health practitioners, healthcare providers, and health policy makers. Circulation. 2013; 127:1730-1753 [M,II]

23519758

GUÍA DE LA AHA PARA MEJORAR LA SALUD CARDIOVASCULAR A NIVEL COMUNITARIO, ACTUALIZACIÓN DE 2013: DECLARACIÓN CIENTÍFICA PARA PROFESIONALES SANITARIOS, ORGANIZACIONES DE ATENCIÓN SAMITARIA Y DISEÑADORES DE POLÍTICAS SANITARIAS

 

Herman WH. The economic costs of diabetes: is it time for a new treatment paradigm? Diabetes Care. 2013; 36:775-776 [AO,I]
23520368
LOS COSTES ECONÓMICOS DE LA DIABETES: ¿ES HORA DE UN NUEVO PARADIGMA DE TRATAMIENTO?

Coustan DR. Can a dietary supplement prevent gestational diabetes mellitus? Diabetes Care. 2013; 36:777-779 [AO,I]

23520369

¿PUEDE PREVENIR UN SUPLEMENTO DIETÉTICO LA DIABETES GESTACIONAL?

 

Fonda SJ, Salkind SJ, Walker MS, Chellappa M, Ehrhardt N, Vigersky RA. Heterogeneity of responses to Real-Time Continuous Glucose Monitoring (RT-CGM) in patients with type 2 diabetes and its implications for application. Diabetes Care. 2013; 36:786-792 [EC,I]

23172975             R/C

HETEROGENEIDAD DE RESPUESTAS A LA MONITORIZACIÓN CONTINUA DE GLUCOSA EN TIEMPO REAL (RT-GCM) EN PACIENTES CON DIABETES TIPO 2 Y SUS IMPLICACIONES PARA SU APLICACIÓN

 

Wolpert HA, Atakov-Castillo A, Smith SA, Steil GM. Dietary fat acutely increases glucose concentrations and insulin requirements in patients with type 1 diabetes: implications for carbohydrate-based bolus dose calculation and intensive diabetes management. Diabetes Care. 2013; 36:810-816 [EC,II]

23193216             R/C

LA GRASA DE LA DIETA AUMENTA LAS CONCENTRACIONES DE GLUCOSA Y LOS REQUERIMIENTOS DE INSULINA EN PACIENTES CON DIABETES TIPO 1: IMPICACIONES PARA EL CÁLCULO DE LA DOSIS DEL BOLO BASADA EN CARBOHIDRATOS Y EL MANEJO INTENSIVO DE LA DIABETES

 

D'Anna R, Scilipoti A, Giordano D, Caruso C, Cannata ML, Interdonato ML, et al. myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled study. Diabetes Care. 2013; 36:854-857 [EC,I]

23340885             R/C

SUPLEMENTO DE MIO-INOSITOL Y APARICIÓN DE DIABETES MELLITUS GESTACIONAL EN MUJERES EMBARAZADAS CON HISTORIA FAMILIAR DE DIABETES TIPO 2: ESTUDIO PROSPECTIVO, ALEATORIZADO, CONTROLADO CON PLACEBO

 

Meneghini L, Atkin SL, Gough SC, Raz I, Blonde L, Shestakova M, et al; NN1250-3668 (BEGIN FLEX) Trial Investigators. The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: a 26-week, randomized, open-label, parallel-group, treat-to-target trial in individuals with type 2 diabetes. Diabetes Care. 2013; 36:858-864 [EC,II]

23340894             R/C

EFICACIA Y SEGURIDAD DE LA INSULINA DEGLUDEC DADA EN DOSIS A INTERVALOS VARIABLES UNA VEZ AL DÍA COMPARADA CON INSULINA GLARGINA E INSULINA DEGLUDEC DOSIFICADAS DIARIAMENTE A LA MISMA HORA: ENSAYO DE 26 SEMANAS POR METAS TERAPÉUTICAS, ALEATORIZADO, DE GRUPO PARALELO SIN ENMASCARAR EN INDIVIDUOS CON DIABETES TIPO 2

 

Logue J, Walker JJ, Leese G, Lindsay R, McKnight J, Morris A, et al; Scottish Diabetes Research Network Epidemiology Group. Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality. Diabetes Care. 2013; 36:887-893 [T,I]

23139375             R/C

ASOCIACIÓN ENTRE IMC MEDIDO DENTRO DEL AÑO SIGUIENTE AL DIAGNÓSTICO DE DIABETES TIPO 2 Y MORTALIDAD

 

Agarwal S, Cox AJ, Herrington DM, Jorgensen NW, Xu J, Freedman BI, et al. Coronary calcium score predicts cardiovascular mortality in diabetes: Diabetes Heart study. Diabetes Care. 2013; 36:972-977 [S,II]

23230101             R/C

LA TABLA DE CALCIO CORONARIO PREDICE LA MORTALIDAD CARDIOVASCULAR EN LA DIABETES: ESTUDIO DIABETES HEART

 

Brand JS, van der Schouw YT, Onland-Moret NC, Sharp SJ, Ong KK, Khaw KT, et al; InterAct Consortium. Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study. Diabetes Care. 2013; 36:1012-1019 [S,II]

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EDAD A LA MENOPAUSIA, VIDA MEDIA REPRODUCTIVA Y RIESGO DE DIABETES TIPO 2: RESULTADOS DEL ESTUDIO EPIC-INTERACT

 

American Diabetes Association. Economic costs of diabetes in the U.S. in 2012. Diabetes Care. 2013; 36:1033-1046 [T,II]

23468086             R/C

LOS COSTES ECONÓMICOS DE LA DIABETES EN EE UU EN 2012

 

Gallwitz B. Novel oral anti-obesity agents: new perspectives with lorcaserin? Drugs. 2013; 73:393-395 [AO,I]
23532530
NUEVOS AGENTES ORALES CONTRA LA OBESIDAD ¿NUEVAS PERSPECTIVAS CON LA LORCASERINA?

Carpenter MJ, Jardin BF, Burris JL, Mathew AR, Schnoll RA, Rigotti NA, et al. Clinical strategies to enhance the efficacy of nicotine replacement therapy for smoking cessation: a review of the literature. Drugs. 2013; 73:407-426 [R,I]

23572407             R/C

ESTRATEGIAS CLÍNICAS PARA REFORZAR LA EFICACIA DEL TRATAMIENTO SUSTITUTIVO CON NICOTINA EN EL ABANDONO TABÁQUICO: REVISIÓN DE LA LITERATURA

 

Hoy SM. Lorcaserin: a review of its use in chronic weight management. Drugs. 2013; 73:463-473 [R,I]

23529825             R/C

LORCASERINA: REVISIÓN DE SU USO EN EL MANEJO CRÓNICO DEL PESO

 

Campins M, Moreno-Pérez D, Gil-de Miguel A, González-Romo F, Moraga-Llop FA, Arístegui-Fernández J, et al. Tos ferina en España. Situación epidemiológica y estrategias de prevención y control. Recomendaciones del Grupo de Trabajo de Tos ferina. Enferm Infecc Microbiol Clin. 2013; 31:240-253 [M,II]
23411362             R/C
TOS FERINA EN ESPAÑA. SITUACIÓN EPIDEMIOLÓGICA Y ESTRATEGIAS DE PREVENCIÓN Y CONTROL. RECOMENDACIONES DEL GRUPO DE TRABAJO DE TOS FERINA

 

Faergeman O. Genes and cardiovascular risk. Eur Heart J. 2013; 34:949-950 [AO,I]
23257949
GENES Y RIESGO CARDIOVASCULAR

Ehret GB, Caulfield MJ. Genes for blood pressure: an opportunity to understand hypertension. Eur Heart J. 2013; 34:951-961 [R,I]

23303660             R/C

GENES DE LA PRESIÓN ARTERIAL: OPORTUNIDAD PARA COMPRENDER LA HIPERTENSIÓN

 

Leong DP, Eikelboom JW, Healey JS, Connolly SJ. Atrial fibrillation is associated with increased mortality: causation or association? Eur Heart J. 2013; 34:1027-1030 [AO,I]

23407094

LA FIBRILACIÓN AURICULAR SE ASOCIA CON INCREMENTO DE LA MORTALIDAD: ¿CAUSA O ASOCIACIÓN?

 

O'Donnell MJ, Mente A, Smyth A, Yusuf S. Salt intake and cardiovascular disease: why are the data inconsistent? Eur Heart J. 2013; 34:1034-1040 [R,I]

23257945             R/C

INGESTA DE SAL Y ENFERMEDAD CARDIOVASCULAR: ¿POR QUÉ SON INCOHERENTES LOS DATOS?

 

Lip GY. Stroke and bleeding risk assessment in atrial fibrillation: when, how, and why? Eur Heart J. 2013; 34:1041-1049 [R,II]

23257951             R/C

VALORACIÓN DEL RIESGO DE ICTUS Y DE SANGRADO EN LA FIBRILACIÓN AURICULAR: ¿CUÁNDO, CÓMO Y POR QUÉ?

 

Onuma Y, Thuesen L, van Geuns RJ, van der Ent M, Desch S, Fajadet J, et al; TROFI Investigators. Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study--TROFI trial. Eur Heart J. 2013; 34:1050-1060 [EC,I]

23396493             R/C

ESTUDIO ALEATORIZADO PARA VALORAR EL EFECTO DE LA ASPIRACIÓN DEL TROMBO SOBRE EL ÁREA DE FLUJO EN PACIENTES CON INFARTO DE MIOCARDIO CON ELEVACIÓN DEL ST: ESTUDIO TROFI

 

Andersson T, Magnuson A, Bryngelsson IL, Frøbert O, Henriksson KM, Edvardsson N, et al. All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995-2008: a Swedish nationwide long-term case-control study. Eur Heart J. 2013; 34:1061-1067 [CC,II]

23321349             R/C

MORTALIDAD POR CUALQUIER CAUSA EN 272.186 PACIENTES HOSPITALIZADOS CON FIBRILACIÓN AURICULAR DE INICIO DE 1995 A 2008: ESTUDIO NACIONAL SUECO DE CASO-CONTROL A LARGO PLAZO

 

Giang KW, Björck L, Novak M, Lappas G, Wilhelmsen L, Torén K, et al. Stroke and coronary heart disease: predictive power of standard risk factors into old age--long-term cumulative risk study among men in Gothenburg, Sweden. Eur Heart J. 2013; 34:1068-1074 [S,II]

23303661             R/C

ICTUS Y ENFERMEDAD CARDIACA CORONARIA: PODER PREDICTIVO DE LOS FACTORES DE RIESGO CONVENCIONALES EN LA EDAD AVANZADA -- ESTUDIO DE RIESGO ACUMULADO EN HOMBRES EN GOTEMBURGO, SUECIA

 

Ketteler M, Wolf M, Hahn K, Ritz E. Phosphate: a novel cardiovascular risk factor. Eur Heart J. 2013; 34:1099-1101 [AO,I]

23045267

FOSFATO: UN NUEVO FACTOR DE RIESGO CARDIOVASCULAR

 

Heine GH, Nangaku M, Fliser D. Calcium and phosphate impact cardiovascular risk. Eur Heart J. 2013; 34:1112-1121 [R,II]

23109644             R/C

EL CALCIO Y EL FOSFATO TIENEN IMPACTO SOBRE EL RIESGO CARDIOVASCULAR

 

Messerli FH, Bangalore S. Treatment-resistant hypertension: another Cinderella story. Eur Heart J. 2013; 34:1175-1177 [AO,I]

23386710

HIPERTENSIÓN RESISTENTE AL TRATAMIENTO: OTRA HISTORIA DE LA CENICIENTA

 

Sakata Y, Shimokawa H. Saturated fatty acid intake and cardiovascular risk. Eur Heart J. 2013; 34:1178-1180 [AO,I]

23425524

INGESTA DE ÁCIDOS GRASOS SATURADOS Y RIESGO CARDIOVASCULAR

 

Pinto Pereira SM, Power C. Life course body mass index, birthweight and lipid levels in mid-adulthood: a nationwide birth cohort study. Eur Heart J. 2013; 34:1215-1224 [S,II]

23234645             R/C

ÍNDICE DE MASA CORPORAL A LO LARGO DE LA VIDA, PESO AL NACER Y NIVELES DE LÍPIDOS EN LA VIDA ADULTA MEDIANA: ESTUDIO NACIONAL DE COHORTES DESDE EL NACIMIENTO

 

Yamagishi K, Iso H, Kokubo Y, Saito I, Yatsuya H, Ishihara J, et al; JPHC Study Group. Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study. Eur Heart J. 2013; 34:1225-1232 [S,II]

23404536             R/C

INGESTA EN LA DIETA DE ÁCIDOS GRASOS SATURADOS E INCIDENCIA DE ICTUS Y ENFERMEDAD CARDIACA CORONARIA EN COMUNIDADES JAPONESAS: ESTUDIO JPHC

 

Magill MK, Baxley E. Virtuous cycles: patient care, education, and scholarship in the patient-centered medical home. Fam Med. 2013; 45:235-239 [R,I]
23553085             R/C
CÍRCULOS VIRTUOSOS: ATENCIÓN AL PACIENTE, FORMACIÓN Y BECAS EN EL CENTRO DE ATENCIÓN PRIMARIA ORIENTADO AL PACIENTE

Newman RJ, Cummings DM, Lukosius E, Patel H, Carmon T. A survey of exercise stress test training in US family medicine residency programs. Fam Med. 2013; 45:247-251 [T,I]

23553087             R/C

ENCUESTA DE CAPACITACIÓN EN PRUEBAS DE ESTRÉS DE EJERCICIO EN LOS PROGRAMAS DE RESIDENCIA DE MEDICINA DE FAMILIA EN EE UU

 

Hughes AK. Mid-to-late-life women and sexual health: communication with health care providers. Fam Med. 2013; 45:252-256 [C,I]

23553088             R/C

MUJERES DE EDAD MEDIANA A AVANZADA Y SALUD SEXUAL: COMUNICACIÓN CON LOS PROFESIONALES DE ATENCIÓN SANITARIA

 

Mainous III AG, Johnson SP, Chirina S, Baker R. Academic family physicians' perception of genetic testing and integration into practice: a CERA study. Fam Med. 2013; 45:257-262 [T,I]

23553089             R/C

PERCEPCIÓN POR PARTE DE LOS MÉDICOS DE FAMILIA DOCENTES DE LAS PRUEBAS GENÉTICAS Y SU INTEGRACIÓN EN LA CONSULTA: UN ESTUDIO CERA

 

Kobus AM, Harman JS, Do HD, Garvin RD. Challenges to depression care documentation in an EHR. Fam Med. 2013; 45:268-271 [T,I]

23553091             R/C

RETOS PARA LA DOCUMENTACIÓN DE LA ATENCIÓN A LA DEPRESIÓN EN UNA HISTORIA CLÍNICA ELECTRÓNICA

 

Kruse J. Income ratio and medical student specialty choice: the primary importance of the ratio of mean primary care physician income to mean consulting specialist income. Fam Med. 2013; 45:281-283 [AO,I]

23553096

PROPORCIÓN DE INGRESOS ECONÓMICOS Y ELECCIÓN DE ESPECIALIDAD POR LOS ESTUDIANTES MÉDICOS: LA IMPORTANCIA PRIMORDIAL DE LA PROPORCIÓN DE INGRESOS PRINCIPALES DEL MÉDICO DE ATENCIÓN PRIMARIA CON RESPECTO A LOS INGRESOS PRINCIPALES DE LOS ESPECIALISTAS CONSULTORES

 

Guldin MB, Vedsted P, Jensen AB, Olesen F, Zachariae R. Bereavement care in general practice: a cluster-randomized clinical trial. Fam Pract. 2013; 30:134-141 [EC,I]
22964078             R/C
ATENCIÓN AL DUELO EN LA CONSULTA DE MEDICINA GENERAL: ENSAYO CLÍNICO ALEATORIZADO AGRUPADO

Ingebrigtsen SG, Scheel BI, Hart B, Thorsen T, Holtedahl K. Frequency of 'warning signs of cancer' in Norwegian general practice, with prospective recording of subsequent cancer. Fam Pract. 2013; 30:153-160 [S,I]

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FRECUENCIA DE LOS "SIGNOS DE ALARMA DEL CÁNCER" EN LA CONSULTA DE MEDICINA GENERAL EN NORUEGA, CON REGISTRO PROSPECTIVO DE CÁNCER POSTERIOR

 

Kirschner K, Braspenning J, Akkermans RP, Jacobs JE, Grol R. Assessment of a pay-for-performance program in primary care designed by target users. Fam Pract. 2013; 30:161-171 [QE,II]

22997223             R/C

VALORACIÓN DE UN PROGRAMA DE PAGO POR RENDIMIENTO EN ATENCIÓN PRIMARIA DISEÑADO POR USUARIOS FINALES

 

Brilleman SL, Salisbury C. Comparing measures of multimorbidity to predict outcomes in primary care: a cross sectional study. Fam Pract. 2013; 30:172-178 [T,I]

23045354             R/C

COMPARAR MEDIDAS DE MULTIMORBILIDAD PARA PREDECIR RESULTADOS EN ATENCIÓN PRIMARIA: ESTUDIO TRANSVERSAL

 

Stigler FL, Starfield B, Sprenger M, Salzer HJ, Campbell SM. Assessing primary care in Austria: room for improvement. Fam Pract. 2013; 30:185-189 [C,II]

23148121             R/C

VALORAR LA ATENCIÓN PRIMARIA EN AUSTRIA: ESPACIO PARA LA MEJORA

 

Magin P, Holliday S, Dunlop A, Ewald B, Dunbabin J, Henry J, et al. Discomfort sharing the general practice waiting room with mentally ill patients: a cross-sectional study. Fam Pract. 2013; 30:190-196 [T,I]

23024372             R/C

INCOMODIDAD AL COMPARTIR LA SALA DE ESPERA DE LA CONSULTA DE MEDICINA GENERAL CON PACIENTES CON ENFERMEDAD MENTAL: ESTUDIO TRANSVERSAL

 

Hilts L, Howard M, Price D, Risdon C, Agarwal G, Childs A. Helping primary care teams emerge through a quality improvement program. Fam Pract. 2013; 30:204-211 [C,I]

22990026             R/C

AYUDAR A EMERGER A LOS EQUIPOS DE ATENCIÓN PRIMARIA A TRAVÉS DE UN PROGRAMA DE MEJORA DE LA CALIDAD

 

MacKichan F, Paterson C, Britten N. GP support for self-care: the views of people experiencing long-term back pain. Fam Pract. 2013; 30:212-218 [C,I]

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APOYO AL AUTOCUIDADO: PUNTOS DE VISTA DE PERSONAS QUE EXPERIMENTAN DOLOR DE ESPALDA A LARGO PLAZO

 

Senosiain C, Tavío E, Moreira V, Maroto M, García MC, Aicart M, et al. Pancreatitis aguda por hipertrigliceridemia. Gastroenterol Hepatol. 2013; 36:274-279 [R,I]
23522394             R/C
PANCREATITIS AGUDA POR HIPERTRIGLICERIDEMIA

 

GUT

Chen HP, Shieh JJ, Chang CC, Chen TT, Lin JT, Wu MS, et al. Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut. 2013; 62:606-615 [CC,I]
22773548             R/C
LA METFORMINA DISMINUYE EL RIESGO DE CARCINOMA HEPATOCELULAR DE FORMA DEPENDIENTE DE LA DOSIS: ESTUDIOS POBLACIONAL E IN VITRO

Lee YC, Chen TH, Chiu HM, Shun CT, Chiang H, Liu TY, et al. The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. Gut. 2013; 62:676-682 [S,II]

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EL BENEFICIO DE LA ERRADICACIÓN MASIVA DE LA INFECCIÓN POR HELICOBACTER PYLORI: ESTUDIO COMUNITARIO DE PREVENCIÓN DEL CÁNCER GÁSTRICO

 

Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, et al; Alliance for Clinical Trials in Oncology. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013; 309:1359-1367 [EC,II]
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EFECTO DE LA DULOXETINA SOBRE EL DOLOR, LA FUNCIÓN Y LA CALIDAD DE VIDA EN PACIENTES CON NEUROPATÍA PERIFÉRICA DOLOROSA INDUCIDA POR QUIMIOTERAPIA: ENSAYO CLÍNICO ALEATORIZADO

Greene M, Justice AC, Lampiris HW, Valcour V. Management of human immunodeficiency virus infection in advanced age. JAMA .2013; 309:1397-1405 [R,I]

23549585             R/C

MANEJO DEL VIRUS DE LA INMUNODEFICIENCIA HUMANO EN LA EDAD AVANZADA

 

Robertson MC, Gillespie LD. Fall prevention in community-dwelling older adults. JAMA. 2013; 309:1406-1407 [AO,II]

23549586             R/C

PREVENCIÓN DE CAÍDAS EN ADULTOS MAYORES RESIDENTES EN LA COMUNIDAD

 

Ginsburg GS. Realizing the opportunities of genomics in health care. JAMA. 2013; 309:1463-1464 [AO,I]

23571581

DARSE CUENTA DE LAS OPORTUNIDADES DE LA GENÉTICA EN LA ATENCIÓN SANITARIA

 

Korf BR, Rehm HL. New approaches to molecular diagnosis. JAMA. 2013; 309:1511-1521 [R,I]

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NUEVOS ABORDAJES AL DIAGNÓSTICO MOLECULAR

 

Feero WG. Genomics in medicine: maturation, but not maturity. JAMA  2013; 309:1522-1524 [AO,I]

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GENÉTICA EN MEDICINA: MADURACIÓN, PERO NO MADUREZ

 

Nussbaum RL. Genome-wide association studies, Alzheimer disease, and understudied populations. JAMA. 2013; 309:1527-1528 [AO,I]

23571593

ESTUDIOS DE ASOCIACIÓN GENÉTICA AMPLIA, ENFERMEDAD DE ALZHEIMER Y POBLACIONES INFRAESTUDIADAS

 

Butler J, Fonarow GC, Gheorghiade M. Strategies and opportunities for drug development in heart failure. JAMA. 2013; 309:1593-1594 [AO,I]

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ESTRATEGIAS Y OPORTUNIDADES DE DESARROLLO DE MEDICAMENTOS PARA LA INSUFICIENCIA CARDIACA

 

Smith R, McCready T, Yusuf S. Combination therapy to prevent cardiovascular disease: slow progress. JAMA. 2013; 309:1595-1596 [AO,I]

23529576

TERAPIA COMBINADA PARA PREVENIR LA ENFERMEDAD CARDIOVASCULAR: PROGRESO LENTO

 

Romanello S, Spiri D, Marcuzzi E, Zanin A, Boizeau P, Riviere S, et al. Association between childhood migraine and history of infantile colic. JAMA. 2013; 309:1607-1612 [CC,I]

23592105             R/C

ASOCIACIÓN ENTRE LA MIGRAÑA EN LOS NIÑOS Y EL CÓLICO INFANTIL

 

Teo K, Lear S, Islam S, Mony P, Dehghan M, Li W, et al; PURE Investigators. Prevalence of a healthy lifestyle among individuals with cardiovascular disease in high-, middle- and low-income countries: The Prospective Urban Rural Epidemiology (PURE) study. JAMA. 2013; 309:1613-1621 [S,II]

23592106             R/C

PREVALENCIA DE HÁBITOS DE VIDA SANOS ENTRE INDIVIDUOS CON ENFERMEDAD CARDIOVASCULAR EN PAÍSES DE ALTOS, MEDIOS Y BAJOS INGRESOS: ESTUDIO PURE

 

Epstein LG, Zee PC. Infantile colic and migraine. JAMA. 2013; 309:1636-1637 [AO,I]

23592110

CÓLICO INFANTIL Y MIGRAÑA

 

Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA. 2013; 309:1696-1703 [S,II]

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EXPOSICIÓN PRENATAL AL VALPROATO Y RIESGO DE TRASTORNOS DEL ESPECTRO DEL AUTISMO Y AUTISMO INFANTIL

 

Crochet JR, Bastian LA, Chireau MV. Does this woman have an ectopic pregnancy?: the rational clinical examination systematic review. JAMA. 2013; 309:1722-1729 [M,II]

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¿TIENE ESTA MUJER UN EMBARAZO ECTÓPICO?: REVISIÓN SISTEMÁTICA DE LA EXPLORACIÓN CLÍNICA RACIONAL

 

Gallo S, Comeau K, Vanstone C, Agellon S, Sharma A, Jones G, et al. Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial. JAMA. 2013; 309:1785-1792 [EC,I]

23632722             R/C

EFECTO DE DIFERENTES DOSIS DE SUPLEMENTOS ORALES DE VITAMINA D SOBRE EL ESTATUS DE VITAMINA D EN LACTANTES SANOS: ENSAYO ALEATORIZADO

 

Dobson SR, McNeil S, Dionne M, Dawar M, Ogilvie G, Krajden M, et al. Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial. JAMA. 2013; 309:1793-1802 [EC,II]

23632723             R/C

INMUNOGENICIDAD DE 2 DOSIS DE VACUNA DE VPH EN LAS ADOLESCENTES MÁS JÓVENES FRENTE A 3 DOSIS EN MUJERES JÓVENES: ENSAYO CLÍNICO ALEATORIZADO

 

Serenius F, Källén K, Blennow M, Ewald U, Fellman V, Holmström G, et al; EXPRESS Group. Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden. JAMA. 2013; 309:1810-1820 [S,I]

23632725             R/C

RESULTADO EN EL DESARROLLO NEURONAL EN NIÑOS EXTREMADAMENTE PRETÉRMINO A LOS 2,5 AÑOS DESPUÉS DE CUIDADOS PERINATALES ACTIVOS EN SUECIA

 

Abrams SA. Targeting dietary vitamin D intakes and plasma 25-hydroxyvitamin D in healthy infants. JAMA. 2013; 309:1830-1831 [AO,I]

23632728

TOMAS DE VITAMINA D EN LA DIETA CON OBJETIVOS DEFINIDOS Y 25-HIDROXIVITAMINA D PLASMÁTICA EN NIÑOS SANOS

 

Kahn JA, Bernstein DI. HPV vaccination: too soon for 2 doses? JAMA. 2013; 309:1832-1834 [AO,I]

23632729

VACUNACIÓN DE VPH: ¿DEMASIADO PRONTO PARA 2 DOSIS?

 

Wilt TJ, Macdonald R, Ouellette J, Khawaja IS, Rutks I, Butler M, et al. Pharmacologic therapy for primary restless legs syndrome: a systematic review and meta-analysis. JAMA Intern Med. 2013; 173:496-505 [M,I]
23460396             R/C
TRATAMIENTO FARMACOLÓGICO PARA EL SÍNDROME DE LAS PIERNAS INQUIETAS: REVISIÓN SISTEMÁTICA Y METAANÁLISIS

Linsky A, Simon SR. Reversing gears: discontinuing medication therapy to prevent adverse events comment on "proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals". JAMA Intern Med. 2013; 173:524-525 [AO,I]

23459795

MARCHAS ATRÁS: INTERRUPCIÓN DEL TRATAMIENTO MEDICAMENTOSO PARA PREVENIR LOS ACONTECIMIENTOS ADVERSOS, COMENTARIO SOBRE "INHIBIDORES DE LA BOMBA DE PROTONES Y RIESGO DE MORTALIDAD Y REHOSPITALIZACIÓN AL CABO DE 1 AÑO EN PACIENTES ANCIANOS DADOS DE ALTA EN HOSPITALES DE ATENCIÓN DE AGUDOS"

 

Singh S, Chang HY, Richards TM, Weiner JP, Clark JM, Segal JB. Glucagonlike Peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med. 2013; 173:534-539 [CC,I]

23440284             R/C

TERAPIAS BASADAS EN PÉPTIDO ANÁLOGO AL GLUCAGÓN 1 Y RIESGO DE HOSPITALIZACIÓN POR PANCREATITIS AGUDA EN LA DIABETES MELLITUS TIPO 2: ESTUDIO POBLACIONAL CASO-CONTROL EMPAREJADO

 

Gier B, Butler PC. Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer? Comment on "glucagonlike Peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus". JAMA Intern Med. 2013; 173:539-541 [AO,I]

23463371

FÁRMACOS BASADOS EN EL PÉPTIDO ANÁLOGO AL GLUCAGÓN 1 Y PANCREATITIS: AL FIN CLARIDAD, PERO ¿QUÉ HAY DEL CÁNCER DE PÁNCREAS? COMENTARIO SOBRE " TERAPIAS BASADAS EN PÉPTIDO ANÁLOGO AL GLUCAGÓN 1 Y RIESGO DE HOSPITALIZACIÓN POR PANCREATITIS AGUDA EN LA DIABETES MELLITUS TIPO 2"

 

Cooper GS, Kou TD, Rex DK. Complications following colonoscopy with anesthesia assistance: a population-based analysis. JAMA Intern Med. 2013; 173:551-556 [S,II]

23478904             R/C

COMPLICACIONES POSTERIORES A LA COLONOSCOPIA CON ASISTENCIA ANESTÉSICA: ANÁLISIS POBLACIONAL

 

Wernli KJ, Inadomi JM. Anesthesia for colonoscopy: too much of a good thing? Comment on "complications following colonoscopy with anesthesia assistance". JAMA Intern Med. 2013; 173:556-558 [AO,I]

23479078

ANESTESIA EN LA COLONOSCOPIA: ¿DEMASIADO DE ALGO BUENO? COMENTARIO SOBRE "COMPLICACIONES POSTERIORES A LA COLONOSCOPIA CON ASISTENCIA ANESTÉSICA: ANÁLISIS POBLACIONAL"

 

Bero L. Industry sponsorship and research outcome: a Cochrane review. JAMA Intern Med. 2013; 173:580-581 [AO,I]

23440226

PATROCINIO DE LA INDUSTRIA Y RESULTADO DE LA INVESTIGACIÓN: REVISIÓN COCHRANE

 

Larsson SC. Are calcium supplements harmful to cardiovascular disease?: comment on " Dietary and supplemental calcium intake and cardiovascular diseases mortality: the National Institutes of Health-AARP Diet and Health study". JAMA Intern Med. 2013; 173:647-648 [AO,I]

23380757

¿SON PERJUDICIALES LOS SUPLEMENTOS DE CALCIO PARA LA ENFERMEDAD CARDIOVASCULAR? COMENTARIO SOBRE "INGESTA DE CALCIO DIETÉTICA Y SUPLEMENTARIA Y MORTALIDAD POR ENFERMEDADES CARDIOVASCULARES: ESTUDIO AARP DIETA Y SALUD DE LOS NATIONAL INSTITUTES OF HEALTH"

 

Tzoulaki I, Siontis KC, Evangelou E, Ioannidis JP. Bias in associations of emerging biomarkers with cardiovascular disease. JAMA Intern Med. 2013; 173:664-671 [M,II]

23529078             R/C

SESGO EN LAS ASOCIACIONES DE LOS BIOMARCADORES EMERGENTES CON LA ENFERMEDAD CARDIOVASCULAR

 

Nissen SE. Biomarkers in cardiovascular medicine: the shame of publication bias; comment on "bias in associations of emerging biomarkers with cardiovascular disease". JAMA Intern Med. 2013; 173:671-672 [AO,I]

23529374

BIOMARCADORES EN MEDICINA CARDIOVASCULAR: LA VERGÜENZA DEL SESGO DE PUBLICACIÓN; COMENTARIO SOBRE "SESGO EN LAS ASOCIACIONES DE LOS BIOMARCADORES EMERGENTES CON LA ENFERMEDAD CARDIOVASCULAR"

 

Copeland WE, Wolke D, Angold A, Costello EJ. Adult psychiatric outcomes of bullying and being bullied by peers in childhood and adolescence. JAMA Psychiatry. 2013; 70:419-426 [S,I]
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RESULTADOS PSIQUIÁTRICOS EN LA VIDA ADULTA DEL ACOSO Y DE SER ACOSADO POR LOS COMPAÑEROS EN LA NIÑEZ Y LA ADOLESCENCIA

 

Ballaz A, Salinas C, Aguirre U, López de Goicoechea MJ, Diez R, Egurrola M. Análisis de la discordancia entre la prueba de la tuberculina y el QuantiFERON-TB ® Gold In-Tube en estudios de contactos. Med Clin (Barc). 2013; 140:289-295 [T,I]
23339888             R/C
ANÁLISIS DE LA DISCORDANCIA ENTRE LA PRUEBA DE LA TUBERCULINA Y EL QUANTIFERON-TB ® GOLD IN-TUBE EN ESTUDIOS DE CONTACTOS

Marrodán MD, Martínez-Álvarez JR, González-Montero M, López-Ejeda N, Cabañas MD, Prado C. Precisión diagnóstica del índice cintura-talla para la identificación del sobrepeso y de la obesidad infantil. Med Clin (Barc). 2013; 140:296-301 [T,I]

22726769             R/C

PRECISIÓN DIAGNÓSTICA DEL ÍNDICE CINTURA-TALLA PARA LA IDENTIFICACIÓN DEL SOBREPESO Y DE LA OBESIDAD INFANTIL

 

García-Gasalla M. ¿Podemos mejorar el estudio de contactos en la tuberculosis? Med Clin (Barc). 2013; 140:305-306 [AO,I]

23337448

¿PODEMOS MEJORAR EL ESTUDIO DE CONTACTOS EN LA TUBERCULOSIS?

 

Calvo JM. Riesgo de recurrencia en la enfermedad tromboembólica venosa tras suspender la anticoagulación. Med Clin (Barc). 2013; 140:310-313  [AO,I]

22995846

RIESGO DE RECURRENCIA EN LA ENFERMEDAD TROMBOEMBÓLICA VENOSA TRAS SUSPENDER LA ANTICOAGULACIÓN

 

Anglès R, Llinás M, Alerany C, Garcia MV. Sistema de notificación genérico y gestión de incidentes: Implantación y acciones de mejora derivadas para la seguridad del paciente. Med Clin (Barc). 2013; 140:320-324 [R,I]

23246168

SISTEMA DE NOTIFICACIÓN GENÉRICO Y GESTIÓN DE INCIDENTES: IMPLANTACIÓN Y ACCIONES DE MEJORA DERIVADAS PARA LA SEGURIDAD DEL PACIENTE

 

Pons JM, Rodés J, Andreu A, Arenas J. La olvidada investigación clínica. Med Clin (Barc). 2013; 140:325-331 [R,I]

23246173

LA OLVIDADA INVESTIGACIÓN CLÍNICA

 

Catalá-López F, Gènova-Maleras R, Ridao M, Alvarez E, Sanfélix-Gimeno G, Morant C, et al. Evaluación de la carga de enfermedad con medidas sintéticas de salud de la población para la Comunidad Valenciana, España: un estudio de base poblacional. Med Clin (Barc). 2013; 140:343-350 [T,I]

22498350             R/C

Evaluación de la carga de enfermedad con medidas sintéticas de salud de la población para la Comunidad Valenciana, España: un estudio de base poblacional

 

Suarez C. ¿Debemos buscar enfermedad subclínica en pacientes de alto riesgo vascular? Med Clin (Barc). 2013; 140:356-357 [AO,I]

23337453

¿DEBEMOS BUSCAR ENFERMEDAD SUBCLÍNICA EN PACIENTES DE ALTO RIESGO VASCULAR?

 

Díaz S, Mayoralas S. Situación actual de la prescripción de oxígeno domiciliario. Med Clin (Barc). 2013; 140:358-359 [AO,I]

23337452

SITUACIÓN ACTUAL DE LA PRESCRIPCIÓN DE OXÍGENO DOMICILIARIO

               

Alonso-Coello P, Rigau D, Solà I, Martínez L. La formulación de recomendaciones en salud: el sistema GRADE. Med Clin (Barc). 2013; 140:366-373 [R,I]

23246171

LA FORMULACIÓN DE RECOMENDACIONES EN SALUD: EL SISTEMA GRADE

 

Bundó M, Urrea M, Muñoz L, Llussà J, Forés R, Torán P. Correlación entre los índices dedo-brazo y tobillo-brazo en pacientes con diabetes mellitus tipo 2. Med Clin (Barc). 2013; 140:390-394  [T,I]

22595253             R/C

CORRELACIÓN ENTRE LOS ÍNDICES DEDO-BRAZO Y TOBILLO-BRAZO EN PACIENTES CON DIABETES MELLITUS TIPO 2

 

Mur T, Villaró M, Porta N, Jaén A. Prevalencia de enfermedad renal crónica en pacientes con diabetes tipo 2 mediante determinación del filtrado glomerular y su relación con el riesgo cardiovascular. Med Clin (Barc). 2013; 140:395-400 [T,I]

22575556             R/C

PREVALENCIA DE ENFERMEDAD RENAL CRÓNICA EN PACIENTES CON DIABETES TIPO 2 MEDIANTE DETERMINACIÓN DEL FILTRADO GLOMERULAR Y SU RELACIÓN CON EL RIESGO CARDIOVASCULAR

 

Sebastián JJ. El síndrome del intestino irritable, ¿ya no debe ser considerado un trastorno funcional? Med Clin (Barc). 2013; 140:403-405 [AO,I]

23337457

EL SÍNDROME DEL INTESTINO IRRITABLE, ¿YA NO DEBE SER CONSIDERADO UN TRASTORNO FUNCIONAL?

 

Navarro C, Núñez I, Fernández A. Síndrome coronario agudo y coronariografía sin lesiones significativas: ¿lo sabemos todo? Med Clin (Barc). 2013; 140:409-414 [R,I]

23177309             R/C

SÍNDROME CORONARIO AGUDO Y CORONARIOGRAFÍA SIN LESIONES SIGNIFICATIVAS: ¿LO SABEMOS TODO?

 

Cohn AC, MacNeil JR, Clark TA, Ortega-Sanchez IR, Briere EZ, Meissner HC, et al; Centers for Disease Control and Prevention (CDC). Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2013; 62(RR-2):1-28 [M,II]
23515099             R/C
PREVENCIÓN Y CONTROL DE LA ENFERMEDAD MENINGOCÓCICA: RECOMENDACIÓN DEL ACIP

 

Patrono C. El ácido acetilsalicílico continúa siendo objeto de investigación y debate 115 años después de su síntesis. Rev Esp Cardiol. 2013; 66:251-254 [AO,I]
23183013
EL ÁCIDO ACETILSALICÍLICO CONTINÚA SIENDO OBJETO DE INVESTIGACIÓN Y DEBATE 115 AÑOS DESPUÉS DE SU SÍNTESIS

Sánchez-Cruz JJ, Jiménez-Moleón JJ, Fernández-Quesada F, Sánchez MJ. Prevalencia de obesidad infantil y juvenil en España en 2012. Rev Esp Cardiol. 2013; 66:371-376  [T,II]

23375996             R/C

PREVALENCIA DE OBESIDAD INFANTIL Y JUVENIL EN ESPAÑA EN 2012

 

Smoke alarm: mental illness and tobacco. Lancet. 2013; 381:1071 [AO,I]
23541368
ALARMA POR HUMO: ENFERMEDAD MENTAL Y TABACO

Europe: a missed opportunity, with dangers and hopes. Lancet. 2013; 381:1072 [AO,I]

23540841

EUROPA: OPORTUNIDAD PERDIDA, CON PELIGROS Y ESPERANZAS

 

Kleinert S, Horton R. Health in Europe--successes, failures, and new challenges. Lancet. 2013; 381:1073-1074 [AO,I]

23541050

SALUD EN EUROPA: ÉXITOS, FRACASOS Y NUEVOS DESAFÍOS

 

Ricciardi W. Health in Europe--policies for progress. Lancet. 2013; 381:1075-1076 [AO,I]

23541051

SALUD EN EUROPA: POLÍTICAS PARA EL PROGRESO

 

Toltzis P, Goldmann D. Rethinking infection prevention research. Lancet. 2013; 381:1078-1079 [AO,I]

23363665

REPENSAR LA INVESTIGACIÓN EN PREVENCIÓN DE LA INFECCIÓN

 

Dewilde WJ, Oirbans T, Verheugt FW, Kelder JC, De Smet BJ, Herrman JP, et al; WOEST study investigators. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet. 2013; 381:1107-1115 [EC,I]

23415013             R/C

USO DE CLOPIDOGREL CON O SIN ASPIRINA EN PACIENTES QUE RECIBEN TRATAMIENTO ANTICOAGULANTE ORAL Y SOMETIDOS A INTERVENCIÓN CORONARIA PERCUTÁNEA: ENSAYO CONTROLADO ALEATORIZADO SIN ENMASCARAR

 

Mackenbach JP, Karanikolos M, McKee M. The unequal health of Europeans: successes and failures of policies. Lancet. 2013; 381:1125-1134 [R,I]

23541053             R/C

LA SALUD DESIGUAL DE LOS EUROPEOS: ÉXITOS Y FRACASOS DE LAS POLÍTICAS

 

Raising the pressure on hypertension. Lancet. 2013; 381:1157 [AO,I]

23561983

LEVANTAR LA PRESIÓN SOBRE LA HIPERTENSIÓN

 

Lin OS. Virtual colonoscopy: stamp of approval or word of warning? Lancet. 2013; 381:1161-1163 [AO,I]

23414649

COLONOSCOPIA VIRTUAL: ¿SELLO DE APROBACIÓN O PALABRAS DE ADVERTENCIA?

 

Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R, et al; SIGGAR investigators. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial. Lancet. 2013; 381:1194-1202 [EC,II]

23414650             R/C

COLONOGRAFÍA TOMOGRÁFICA FRENTE A COLONOSCOPIA EN LA INVESTIGACIÓN DE PACIENTES CON SÍNTOMAS SUBJETIVOS DE CÁNCER COLORRECTAL (SIGGAR): ENSAYO ALEATORIZADO MULTICÉNTRICO

 

Wolfe I, Thompson M, Gill P, Tamburlini G, Blair M, van den Bruel A, et al. Health services for children in western Europe. Lancet. 2013; 381:1224-1234 [R,II]

23541056             R/C

SERVICIONS SANITARIOS PARA NIÑOS EN EUROPA OCCIDENTAL

 

Rechel B, Grundy E, Robine JM, Cylus J, Mackenbach JP, Knai C, et al. Ageing in the European Union. Lancet. 2013; 381:1312-1322 [R,I]

23541057             R/C

ENVEJECIMIENTO EN LA UNIÓN EUROPEA

 

Karanikolos M, Mladovsky P, Cylus J, Thomson S, Basu S, Stuckler D, et al. Financial crisis, austerity, and health in Europe. Lancet. 2013; 381:1323-1331 [R,II]

23541059             R/C

CRISIS FINANCIERA, AUSTERIDAD Y SALUD EN EUROPA

 

Child and adolescent wellbeing in the UK. Lancet. 2013; 381:1334 [AO,I]

23601934

BIENESTAR DE LOS NIÑOS Y ADOLESCENTES EN EL RU

 

Algra AM. Towards a global brief on aspirin. Lancet. 2013; 381:1344-1345 [AO,I]

23601936

HACIA UN INFORME MUNDIAL SOBRE LA ASPIRINA

 

Nair H, Simões EA, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JS, et al; Severe Acute Lower Respiratory Infections Working Group. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet. 2013; 381:1380-1390 [M,II]

23369797             R/C

CARGA REGIONAL Y MUNDIAL DE INGRESOS HOSPITALARIOS POR INFECCIONES RESPIRATORIAS GRAVES DE VÍAS BAJAS EN NIÑOS EN 2010: ANÁLISIS SISTEMÁTICO

 

Walker CL, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhoea. Lancet. 2013; 381:1405-1416 [R,I]

23582727             R/C

CARGA MUNDIAL DE NEUMONÍA Y DIARREA INFANTILES

 

The ongoing problem of tuberculosis in the UK. Lancet. 2013; 381:1431 [AO,I]

23622269

EL PROBLEMA EN CURSO DE LA TUBERCULOSIS EN EL RU

 

The doctor-patient relationship: capturing the ideal. Lancet. 2013; 381:1432 [AO,I]

23622270

RELACIÓN MÉDICO-PACIENTE: CAPTURAR EL IDEAL

 

Elliman D, Bedford H. Should the UK introduce compulsory vaccination? Lancet .2013; 381:1434-1436 [AO,I]

23623214

¿DEBERÍA INTRODUCIR EL RU LA VACUNACIÓN OBLIGATORIA?

 

Poland GA, Poland CM, Howe CL. Influenza vaccine and Guillain-Barré syndrome: making informed decisions. Lancet .2013; 381:1437-1439 [AO,I]

23622271

VACUNA DE LA GRIPE Y SÍNDROME DE GUILLAIN-BARRÉ: TOMAR DECISIONES INFORMADAS

 

Tobacco control--political will needed. Lancet. 2013; 381:1511 [AO,I]

23642683

CONTROL DEL TABACO: SE NECESITARÁ LA POLÍTICA

 

HIV: population-based approaches to a pandemic. Lancet. 2013; 381:1512 [AO,I]

23642684

VIH: ABORDAJES POBLACIONALES DE UNA PANDEMIA

 

Cohen JE. Saving lives with the US Tobacco Control Act. Lancet. 2013; 381:1513-1514 [AO,I]

23642686

SALVAR VIDAS CON LA LEY DE CONTROL DEL TABACO DE EE UU

 

Husten CG, Deyton LR. Understanding the Tobacco Control Act: efforts by the US Food and Drug Administration to make tobacco-related morbidity and mortality part of the USA's past, not its future. Lancet. 2013; 381:1570-1580 [R,I]

23642698             R/C

COMPRENDER LA LEY DE CONTROL DEL TABACO: ESFUERZOS DE LA FDA PARA HACER LA MORBILIDAD Y MORTALIDAD RELACIONADAS CON EL TABACO PARTE DEL PASADO DE EE UU, NO DE SU FUTURO

 

Britton J, Bogdanovica I. Tobacco control efforts in Europe. Lancet. 2013; 381:1588-1595 [R,I]

23642700             R/C

ESFUERZOS POR EL CONTROL DEL TABACO EN EUROPA

 

Southworth MR, Reichman ME, Unger EF. Dabigatran and postmarketing reports of bleeding. N Engl J Med. 2013; 368:1272-1274 [AO,I]
23484796
DABIGATRAN E INFORMES DE SANGRADO TRAS SU COMERCIALIZACIÓN

Tracy SW. Something new under the sun? The Mediterranean diet and cardiovascular health. N Engl J Med. 2013; 368:1274-1276 [AO,I]

23550666

¿ALGO NUEVO BAJO EL SOL? DIETA MEDITERRÁNEA Y SALUD CARDIOVASCULAR

 

Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, et al; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013; 368:1279-1290 [EC,I]

23432189             R/C

PREVENCIÓN PRIMARIA DE LA ENFERMEDAD CARDIOVASCULAR CON DIETA MEDITERRÁNEA

 

Hussain M, Tangen CM, Berry DL, Higano CS, Crawford ED, Liu G, et al. Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med. 2013; 368:1314-1325 [EC,I]

23550669             R/C

DEPRIVACIÓN ANDROGÉNICA INTERMITENTE FRENTE A CONTINUA EN EL CÁNCER DE PRÓSTATA

 

Hurd MD, Martorell P, Delavande A, Mullen KJ, Langa KM. Monetary costs of dementia in the United States. N Engl J Med. 2013; 368:1326-1334 [CE,II]

23550670             R/C

COSTES MONETARIOS DE LA DEMENCIA EN ESTADOS UNIDOS

 

Appel LJ, Van Horn L. Did the PREDIMED trial test a Mediterranean diet? N Engl J Med. 2013; 368:1353-1354 [AO,I]

23550674

¿HA PROBADO UNA DIETA MEDITERRÁNEA EL ENSAYO PREDIMED?

 

Schmidt H, Voigt K, Emanuel EJ. The ethics of not hiring smokers. N Engl J Med. 2013; 368:1369-1371 [AO,I]

23534544

LA ÉTICA DE NO CONTRATAR A FUMADORES

 

Asch DA, Muller RW, Volpp KG. Conflicts and compromises in not hiring smokers. N Engl J Med. 2013; 368:1371-1373 [AO,I]

23534547

CONFLICTOS Y COMPROMISOS AL NO CONTRATAR A FUMADORES

 

Armstrong PW, Gershlick AH, Goldstein P, Wilcox R, Danays T, Lambert Y, et al; STREAM Investigative Team. Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction. N Engl J Med. 2013; 368:1379-1387 [EC,II]

23473396             R/C

FIBRINOLISIS O ICP (INTERVENCIÓN CORONARIA PERCUTÁNEA) PRIMARIA EN EL INFARTO DE MIOCARDIO CON ELEVACIÓN DEL SEGMENTO ST

 

Auerbach DI, Staiger DO, Muench U, Buerhaus PI. The nursing workforce in an era of health care reform. N Engl J Med. 2013; 368:1470-1472 [AO,I]

23594001            

EL PERSONAL DE ENFERMERÍA EN UNA ÉPOCA DE REFORMA DE LA ATENCIÓN SANITARIA

 

Ali MK, Bullard KM, Saaddine JB, Cowie CC, Imperatore G, Gregg EW. Achievement of goals in U.S. diabetes care, 1999-2010. N Engl J Med. 2013; 368:1613-1624 [S,II]

23614587             R/C

CONSECUCIÓN DE OBJETIVOS EN LA ATENCIÓN A LA DIABETES EN EE UU, 1999-2010

 

Mosholder AD, Mathew J, Alexander JJ, Smith H, Nambiar S. Cardiovascular risks with azithromycin and other antibacterial drugs. N Engl J Med. 2013; 368:1665-1668 [AO,I]

23635046 

RIESGOS CARDIOVASCULARES CON LA AZITROMICINA Y OTROS MEDICAMENTOS ANTIBACTERIANOS

 

Lynch HF. Discrimination at the doctor's office. N Engl J Med. 2013; 368:1668-1670 [AO,I]

23635047

DISCRIMINACIÓN EN LA CONSULTA DEL MÉDICO

 

Katz JN, Brophy RH, Chaisson CE, de Chaves L, Cole BJ, Dahm DL, et al. Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med. 2013; 368:1675-1684 [EC,I]

23506518             R/C

CIRUGÍA FRENTE A FISIOTERAPIA EN UN DESGARRO MENISCAL Y ARTROSIS

 

Thomas KS, Crook AM, Nunn AJ, Foster KA, Mason JM, Chalmers JR, et al; U.K. Dermatology Clinical Trials Network's PATCH I Trial Team. Penicillin to prevent recurrent leg cellulitis. N Engl J Med. 2013; 368:1695-1703 [EC,II]

23635049             R/C

PENICILINA PARA PREVENIR LA CELULITIS RECURRENTE DE LA PIERNA

 

Svanström H, Pasternak B, Hviid A. Use of azithromycin and death from cardiovascular causes. N Engl J Med. 2013; 368:1704-1712 [S,II]

23635050             R/C

USO DE AZITROMICINA Y MUERTE POR CAUSAS CARDIOVASCULARES

 

Buchbinder R. Meniscectomy in patients with knee osteoarthritis and a meniscal tear? N Engl J Med. 2013; 368:1740-1741 [AO,I]

23506467

¿MENISCECTOMÍA EN PACIENTES CON ARTROSIS DE RODILLA Y UN DESGARRO MENISCAL?

 

 

Gibson PG. Macrolides for yet another chronic airway disease: severe asthma? Thorax. 2013; 68:313-314 [AO,I]

23349219

¿MACRÓLIDOS PARA OTRA ENFERMEDAD CRÓNICA DE VÍAS RESPIRATORIAS MÁS: ASMA GRAVE?

 

Brusselle GG, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013; 68:322-329 [EC,I]

23291349             R/C

AZITROMICINA EN LA PREVENCIÓN DE LAS EXACERBACIONES DEL ASMA GRAVE (AZISAST): ENSAYO MULCÉNTRICO ALEATORIZADO CONTROLADO CON PLACEBO A DOBLE CIEGO

 

Ellwood P, Asher MI, García-Marcos L, Williams H, Keil U, Robertson C, et al; ISAAC Phase III Study Group. Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Thorax. 2013; 68:351-360 [T,II]

23319429             R/C

¿CAUSAN ASMA, RINOCONJUNTIVITIS Y ECCEMA LAS COMIDAS RÁPIDAS? HALLAZGOS MUNDIALES DEL ESTUDIO ISAAC EN FASE TRES

 

Saad N, Camus P, Suissa S, Ernst P. Statins and the risk of interstitial lung disease: a cohort study. Thorax. 2013; 68:361-364 [S,I]

23299962             R/C

ESTATINAS Y RIESGO DE ENFERMEDAD PULMONAR INTERSTICIAL: ESTUDIO DE COHORTES

 

Krauss-Etschmann S, Bush A, Bellusci S, Brusselle GG, Dahlén SE, Dehmel S, et al. Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax. 2013; 68:380-384 [R,I]

22781122             R/C

DE MOSCAS, RATONES Y HOMBRES: ABORDAJE SISTEMÁTICO PARA LA COMPRENSIÓN DE LA ENFERMEDAD PULMONAR CRÓNICA EN LA VIDA TEMPRANA

 

Brown JS, Hill AT. Macrolides and pneumonia. Thorax. 2013; 68:404-405 [AO,I]

23462154

MACRÓLIDOS Y NEUMONÍA

 

 ACADEMIC MEDICINE

 

S23425980
Deciding on a diagnosis and treatment is essential to the practice of medicine. Developing competence in these clinical reasoning processes, commonly referred to as diagnostic and therapeutic reasoning, respectively, is required for physician success. Clinical reasoning has been a topic of research for several decades, and much has been learned. However, there still exists no clear consensus regarding what clinical reasoning entails, let alone how it might best be taught, how it should be assessed, and the research and practice implications therein.In this article, the authors first discuss two contrasting epistemological views of clinical reasoning and related conceptual frameworks. They then outline four different theoretical frameworks held by medical educators that the authors believe guide educators' views on the topic, knowingly or not. Within each theoretical framework, the authors begin with a definition of clinical reasoning (from that viewpoint) and then discuss learning, assessment, and research implications. The authors believe these epistemologies and four theoretical frameworks also apply to other concepts (or "competencies") in medical education.The authors also maintain that clinical reasoning encompasses the mental processes and behaviors that are shared (or evolve) between the patient, physician, and the environment (i.e., practice setting). Clinical reasoning thus incorporates components of all three factors (patient, physician, environment). The authors conclude by outlining practical implications and potential future areas for research.

S23425984
Biostatistics-the application of statistics to understanding health and biology-provides powerful tools for developing research questions, designing studies, refining measurements, analyzing data, and interpreting findings. Biostatistics plays an important role in health-related research, yet biostatistics resources are often fragmented, ad hoc, or oversubscribed within academic health centers (AHCs). Given the increasing complexity and quantity of health-related data, the emphasis on accelerating clinical and translational science, and the importance of conducting reproducible research, the need for the thoughtful development of biostatistics resources within AHCs is growing.In this article, the authors identify strategies for developing biostatistics resources in three areas: (1) recruiting and retaining biostatisticians, (2) efficiently using biostatistics resources, and (3) improving biostatistical contributions to science. AHCs should consider these three domains in building strong biostatistics resources, which they can leverage to support a broad spectrum of research. For each of the three domains, the authors describe the advantages and disadvantages of AHCs creating centralized biostatistics units rather than dispersing such resources across clinical departments or other research units. They also address the challenges that biostatisticians face in contributing to research without sacrificing their individual professional growth or the trajectory of their research teams. The authors ultimately recommend that AHCs create centralized biostatistics units because this approach offers distinct advantages both to investigators who collaborate with biostatisticians as well as to the biostatisticians themselves, and it is better suited to accomplish the research and education missions of AHCs.

S23425979
Without a substantially accelerated growth in graduate medical education, the physician workforce will fall short of the nation's needs, and competition for available residency positions will radically increase.

 

ANNALS OF INTERNAL MEDICINE

 

S23588746
Use of CAD during screening mammography among Medicare enrollees is associated with increased DCIS incidence, the diagnosis of invasive breast cancer at earlier stages, and increased diagnostic testing among women without breast cancer.

S23588749
Medications reduced the incidence of invasive breast cancer and fractures and increased the incidence of thromboembolic events. Tamoxifen was more effective than raloxifene but also increased the incidence of endometrial cancer and cataracts. Use is limited by adverse effects and inaccurate methods to identify candidates.

S23588748
Accurate, externally validated models for predicting risk for kidney failure in patients with CKD are available and ready for clinical testing. Further development of models for cardiovascular events and all-cause mortality is needed.

S23588747
Abdominal CT images obtained for other reasons that include the lumbar spine can be used to identify patients with osteoporosis or normal BMD without additional radiation exposure or cost.

S23588745
Attention to patient needs and circumstances when planning care is associated with improved health care outcomes.

S23546565
In patients with 1 past calcium stone, increased fluid intake reduced recurrence risk. In patients with multiple past calcium stones, addition of thiazide, citrate, or allopurinol further reduced risk.

S23546564
Statin-related events are commonly reported and often lead to statin discontinuation. However, most patients who are rechallenged can tolerate statins long-term. This suggests that many of the statin-related events may have other causes, are tolerable, or may be specific to individual statins rather than the entire drug class.

 

ARCHIVOS DE BRONCONEUMOLOGIA

 

S23317766
El objetivo de este artículo es destacar la problemática que afecta al cribado del cáncer de pulmón con tomografía computarizada (TC) mediante un análisis exhaustivo de la literatura científica. La publicación del National Lung Screening Trial en 2011 ha indicado que el cribado con TC de fumadores y exfumadores en 3 rondas anuales reduce la mortalidad por cáncer de pulmón en un 20% cuando se compara con el cribado con radiografía de tórax. La primera limitación de esta modalidad de cribado es la falta de descenso en la estadificación en rondas sucesivas de cribado cuando se compara con la ronda inicial. El cribado de cáncer de pulmón con TC también tiene un bajo valor predictivo positivo, similar al porcentaje de cirugías innecesarias realizadas en los falsos positivos. Otro problema es que, actualmente, el sobrediagnóstico del cáncer de pulmón es desconocido. Podemos suponer que si existe sobrediagnóstico cuando la técnica de cribado es la radiografía de tórax, este será mayor cuando se utilice TC. La TC, incluso a dosis bajas, expone a los pacientes a niveles elevados de radiación. La detección de nódulos positivos implica una mayor exposición a radiación, y el número de casos de cáncer inducidos por radiación en los pacientes cribados con TC es desconocido. Por último, los estudios publicados sobre el cribado de cáncer de pulmón con TC son tremendamente heterogéneos. Incluyen diferentes grupos de edad, diferentes categorías de fumadores y exfumadores y diferentes grosores en los cortes de la TC, lo que convierte los resultados en difícilmente comparables. Con estos datos no recomendamos el cribado de cáncer de pulmón con TC de baja dosis para fumadores o exfumadores fuera del contexto de la recomendación individual.

 

ATENCION PRIMARIA

 

S23182318
Las infecciones odontogénicas representan el 10% de las prescripciones antibióticas. A pesar de la reconocida frecuencia e importancia de estas llama la atención la frecuente confusión entre profilaxis y tratamiento. La cavidad bucal forma un complejo ecosistema compuesto por más de 500 especies bacterianas. Es indispensable la anamnesis y exploración de cada infección y conocer los antecedentes que modifiquen nuestra conducta terapéutica y/o profiláctica.

Durante muchos años ha sido aceptado el uso de la profilaxis con antibióticos en pacientes con riesgo de endocarditis infecciosa. Actualmente sus indicaciones se están restringiendo y en muchas ocasiones los riesgos de tomar antibiótico preventivo son superiores a los beneficios.

Carecemos de estudios para conocer el antibiótico y la pauta mejor indicada. Hemos de basarnos en el documento de consenso español. Tampoco sabemos cómo influye el uso de antibióticos en las resistencias, no solo de la cepa patógena sino también en la flora habitual del paciente.

S23274059
Se destacan 5 tipos comportamentales de características peculiares y de interés para la clínica laboral: quemado (desgaste profesional), acosado, satisfecho laboral familiar, satisfecho laboral individual y sociable.

S23265845
Los desfibriladores externos semiautomáticos poseen una muy elevada especificidad y moderadamente alta sensibilidad. Los errores dependientes del operador han sido escasos. Los marcapasos implantados parecen interaccionar con el análisis de los dispositivos.

 

BRITISH MEDICAL JOURNAL

 

S23610376
Using cancer trial publications alone to assess risk of bias could be unreliable; thus, reviewers should be cautious about using them as a basis for trial inclusion, particularly for those trials assessed as unclear risk. Supplementary information from trialists should be sought to enable appropriate assessments and potentially reduce or overcome some risks of bias. Furthermore, guidance should ensure clarity on what constitutes risk of bias, particularly for the more subjective domains.

S23553971
Decisions on the frequency of remeasuring for cardiovascular risk should be made on the basis of baseline risk. Repeat risk estimation before 8-10 years is not warranted for most people initially not requiring treatment. However, remeasurement within a year seems warranted in those with an initial 15-<20% risk.

S23618722
The cohort included 72738 new users of oral antidiabetic drugs (8032 (11%) used sitagliptin; 7293 (91%) were taking it in combination with other agents) followed for a total of 182409 patient years. The mean age was 52 (SD 9) years, 54% (39573) were men, 11% (8111) had ischemic heart disease, and 9% (6378) had diabetes related complications at the time their first antidiabetic drug was prescribed. 14215 (20%) patients met the combined endpoint. Sitagliptin users showed similar rates of all cause hospital admission or mortality to patients not using sitagliptin (adjusted hazard ratio 0.98, 95% confidence interval 0.91 to 1.06), including patients with a history of ischemic heart disease (adjusted hazard ratio 1.10, 0.94 to 1.28) and those with estimated glomerular filtration rate below 60 mL/min (1.11, 0.88 to 1.41).

S23529983
Eight studies were included (n=6521; 802 events; mean follow-up 5.18 years). The relative risk for all cause mortality or cardiovascular events, or both comparing a total coronary artery calcium score of ≥10 with a score of <10 was 5.47 (95% confidence interval 2.59 to 11.53; I(2)=82.4%, P<0.001). The overall sensitivity of a total coronary artery calcium score of ≥10 for this composite outcome was 94% (95% confidence interval 89% to 96%), with a specificity of 34% (24% to 44%). The positive and negative likelihood ratios were 1.41 (95% confidence interval 1.20 to 1.66) and 0.18 (0.10 to 0.30), respectively. For people with a coronary artery calcium score of <10, the post-test probability of the composite outcome was about 1.8%, representing a 6.8-fold reduction from the pretest probability. Four studies evaluated cardiovascular events as the outcome (n=1805; 351 events). The relative risk for cardiovascular events comparing a total coronary artery calcium score of ≥10 with a score of <10 was 9.22 (2.73 to 31.07; I(2)=76.7%, P=0.005). The positive and negative likelihood ratios were 1.67 (1.30 to 2.17) and 0.11 (0.04 to 0.29), respectively.

S23550046
A validated prediction model, including clinical signs, symptoms, and C reactive protein level, was useful for estimating the likelihood of pneumonia and other SBIs in children with fever, such as septicaemia/meningitis and urinary tract infections.

S23558162
A modest reduction in salt intake for four or more weeks causes significant and, from a population viewpoint, important falls in blood pressure in both hypertensive and normotensive individuals, irrespective of sex and ethnic group. Salt reduction is associated with a small physiological increase in plasma renin activity, aldosterone, and noradrenaline and no significant change in lipid concentrations. These results support a reduction in population salt intake, which will lower population blood pressure and thereby reduce cardiovascular disease. The observed significant association between the reduction in 24 hour urinary sodium and the fall in systolic blood pressure, indicates that larger reductions in salt intake will lead to larger falls in systolic blood pressure. The current recommendations to reduce salt intake from 9-12 to 5-6 g/day will have a major effect on blood pressure, but a further reduction to 3 g/day will have a greater effect and should become the long term target for population salt intake.

S23558163
High quality evidence in non-acutely ill adults shows that reduced sodium intake reduces blood pressure and has no adverse effect on blood lipids, catecholamine levels, or renal function, and moderate quality evidence in children shows that a reduction in sodium intake reduces blood pressure. Lower sodium intake is also associated with a reduced risk of stroke and fatal coronary heart disease in adults. The totality of evidence suggests that most people will likely benefit from reducing sodium intake.

S23616031
Treatment effect estimates differed within meta-analyses solely based on trial sample size, with stronger effect estimates seen in small to moderately sized trials than in the largest trials.

S23558164
High quality evidence shows that increased potassium intake reduces blood pressure in people with hypertension and has no adverse effect on blood lipid concentrations, catecholamine concentrations, or renal function in adults. Higher potassium intake was associated with a 24% lower risk of stroke (moderate quality evidence). These results suggest that increased potassium intake is potentially beneficial to most people without impaired renal handling of potassium for the prevention and control of elevated blood pressure and stroke.

S23613540
Most authors of Cochrane reviews who searched for unpublished data received useful information, primarily from trialists. Our response rate was low and the authors who did not respond were probably less likely to have searched for unpublished data. Manufacturers and regulatory agencies were uncommon sources of unpublished data.

S23571838
In relation to the Cuban experience in 1980-2010, there is an association at the population level between weight reduction and death from diabetes and cardiovascular disease; the opposite effect on the diabetes and cardiovascular burden was seen on population-wide weight gain.

S23568792
Overall, patients with rheumatoid arthritis who have not been treated with biological drugs are not at increased risk of invasive melanoma compared with the general population. Rheumatoid arthritis patients selected for TNF inhibitor treatment are not at increased overall risk for cancer but have a 50% increased relative risk of invasive melanoma. Given the small increase in absolute risk, these finding may not markedly shift the overall risk-benefit balance of TNF inhibitors as used in clinical practice but might do so in patients at high risk of melanoma for other reasons.

S23604083
In utero exposure to both SSRIs and non-selective monoamine reuptake inhibitors (tricyclic antidepressants) was associated with an increased risk of autism spectrum disorders, particularly without intellectual disability. Whether this association is causal or reflects the risk of autism with severe depression during pregnancy requires further research. However, assuming causality, antidepressant use during pregnancy is unlikely to have contributed significantly towards the dramatic increase in observed prevalence of autism spectrum disorders as it explained less than 1% of cases.

 

CANADIAN MEDICAL ASSOCIATION JOURNAL

 

S23509128
The risk of cholecystectomy was increased among women exposed to oral estrogen menopausal hormone therapy, especially oral regimens without a progestagen. Complicated gallstone disease should be added to the list of potential adverse events to be considered when balancing the benefits and risks associated with menopausal hormone therapy.

S23439620
Within a universal health insurance system in which physician reimbursement is unaffected by patients' socioeconomic status, people presenting themselves as having high socioeconomic status received preferential access to primary care over those presenting themselves as having low socioeconomic status.

 

CIRCULATION

 

S23481623
The changing associations of metabolic risk factors with macroeconomic variables indicate that there will be a global pandemic of hyperglycemia and diabetes mellitus, together with high blood pressure in low-income countries, unless effective lifestyle and pharmacological interventions are implemented.

S23513066
Although increasing age predicts worsening outcomes in the elderly, the absolute rates are modest, even in nonagenarians, and comorbidity is a stronger predictor.

 

DIABETES CARE

 

S23468086
The estimated total economic cost of diagnosed diabetes in 2012 is $245 billion, a 41% increase from our previous estimate of $174 billion (in 2007 dollars). This estimate highlights the substantial burden that diabetes imposes on society. Additional components of societal burden omitted from our study include intangibles from pain and suffering, resources from care provided by nonpaid caregivers, and the burden associated with undiagnosed diabetes.

S23172975
The patterns identified suggest that targeting people with higher starting A1Cs, using it short-term (e.g., 2 weeks), and monitoring for worsening glycemia that might be the result of burnout may be the best approach to using RT-CGM in people with type 2 diabetes not taking prandial insulin.

S23340885
myo-Inositol supplementation in pregnant women with a family history of type 2 diabetes may reduce GDM incidence and the delivery of macrosomia fetuses.

S23340894
The use of extreme dosing intervals of 8-40 h demonstrates that the daily injection time of IDeg can be varied without compromising glycemic control or safety.

S23230098
Early menopause is associated with a greater risk of type 2 diabetes

S23139375
Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study.

S23230101
In T2DM, CAC predicts CVD mortality and meaningfully reclassifies participants, suggesting clinical utility as a risk stratification tool in a population already at increased CVD risk.

S23193216
This evidence that dietary fat increases glucose levels and insulin requirements highlights the limitations of the current carbohydrate-based approach to bolus dose calculation. These findings point to the need for alternative insulin dosing algorithms for higher-fat meals and suggest that dietary fat intake is an important nutritional consideration for glycemic control in individuals with type 1 diabetes.

 

DRUGS

 

S23529825
Oral lorcaserin (BELVIQ(®)), a selective serotonin 5-HT2C receptor agonist, is indicated in the US as an adjunct to diet and exercise in the chronic weight management of obese adults, or overweight adults with at least one weight-related comorbidity (e.g. dyslipidaemia, hypertension, type 2 diabetes). This article reviews the pharmacological properties, therapeutic efficacy and tolerability of oral lorcaserin in this patient population. In three large randomized, double-blind, multicentre studies, oral lorcaserin was more effective than placebo in the management of obese and overweight adults with or without type 2 diabetes mellitus. Following 12 months' therapy, significantly higher proportions of lorcaserin than placebo recipients achieved a ≥5 and ≥10 % reduction from baseline in their bodyweight and a significant between-group difference favouring lorcaserin over placebo was observed for the change from baseline in bodyweight. Moreover, among patients who had achieved a ≥5 % reduction in their bodyweight after 12 months' therapy with lorcaserin, a significantly higher proportion who received lorcaserin for a further 12 months than those who switched to placebo maintained ≥5 % weight loss at 24 months. In general, oral lorcaserin was well tolerated in clinical studies, with hypoglycaemia and headache the most frequently reported adverse events in those with or without type 2 diabetes, respectively. According to a pooled analysis, the risk of US-FDA-defined valvulopathy with lorcaserin is generally low and not statistically significantly different from placebo. From these and other data, the FDA has concluded that lorcaserin is unlikely to elevate the risk of valvulopathy.

S23572407
A number of smoking cessation pharmacotherapies have led to increases in quitting and thus to significant benefits to public health. Among existing medications, nicotine replacement therapy (NRT) has been available the longest, has the largest literature base in support, and is the only option for over-the-counter access. While the short-term efficacy of NRT is well documented in clinical trials, long-term abstinence rates associated with using NRT are modest, as most smokers will relapse. This literature review examines emerging clinical strategies to improve NRT efficacy. After an initial overview of NRT and its FDA-approved indications for use, we review randomized trials in which clinical delivery of NRT was manipulated and tested, in an attempt to enhance efficacy, through (1) duration of use (pre-quit and extended use), (2) amount of use (high-dose and combination NRT), (3) tailoring to specific smoker groups (genotype and phenotype), or (4) use of NRT for novel purposes (relapse prevention, temporary abstinence, cessation induction). Outcomes vary within and across topic area, and we highlight areas that offer stronger promise. Combination NRT likely represents the most promising strategy moving forward; other clinical strategies offer conflicting evidence but deserve further testing (pre-quit NRT or tailored treatment) or offer potential utility but are in need of further, direct tests. Some areas, though based on a limited set of studies, do not offer great promise (high-dose and extended treatment NRT). We conclude with a brief discussion of emergent NRT products (e.g., oral nicotine spray, among others), which may ultimately offer greater efficacy than current formulations. In order to further lower the prevalence of smoking, novel strategies designed to optimize NRT efficacy are needed.

 

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA

 

S23411362
En los últimos años se está observando una reemergencia de la tos ferina en los países con amplias coberturas vacunales, con la aparición de brotes importantes. Este aumento de la incidencia tiene una distribución por edades bipolar: en los lactantes menores de 6meses, que por su edad no han iniciado la vacunación o no han completado la primovacunación, y en los adolescentes y adultos por la disminución de su inmunidad, vacunal o natural, con el tiempo transcurrido desde la inmunización o el padecimiento de la enfermedad. Estos cambios epidemiológicos justifican la adopción de nuevas estrategias vacunales con la finalidad de proteger al lactante pequeño y disminuir la incidencia de la enfermedad en toda la población.

La vacunación del adolescente y del adulto debería ser prioritaria; en el primer caso solo supone cambiar la vacuna dT por la dTpa, con un coste adicional pequeño. La vacunación del adulto puede ser más difícil de implementar, pero de la misma forma que en muchos países se revacuna cada 10años frente a la difteria y el tétanos (con la vacuna dT), debería hacerse también frente a la tos ferina (con la vacuna dTpa). La estrategia que puede tener un impacto más importante sobre la incidencia de la tos ferina en el lactante es la vacunación de las personas con quienes convive o va a convivir, lo que se conoce como estrategia del nido. Recientemente, en algunos países se ha introducido también la vacunación de la embarazada, a partir de las 20semanas de gestación, como la forma más efectiva para proteger al recién nacido.

 

EUROPEAN HEART JOURNAL

 

S23404536
In this Japanese population, SFAs intake was inversely associated with deep intraparenchymal haemorrhage and lacunar infarction and positively associated with myocardial infarction.

S23303660
Hypertension (HTN) is quantitatively the major cardiovascular risk factor and responsible for ~50% of cardiovascular morbidity and mortality. Blood pressure (BP) is also a classical complex genetic trait with heritability estimates of 30-50%. Although much is known about BP regulation, the intrinsic origin of essential HTN remains obscure although many environmental factors are known. Analyses of rare monogenic syndromes of HTN have focused attention on pathways that involve renal sodium handling, and steroid hormone metabolism including the mineralocorticoid receptor activity. The genetic basis of common essential HTN on the other hand is only just becoming accessible through high-throughput approaches. Unbiased genome-wide analyses of BP genomics have identified 43 genetic variants associated with systolic, diastolic BP, and HTN. It is highly likely based on current findings that there are hundreds of such loci with small effects on BP, opening a perspective on the genetic architecture of BP that was unknown before. It is our hope that the knowledge of these and further loci will lead to improved understanding of BP pathophysiology and to the identification of new targets for drug therapy.

S23321349
Atrial fibrillation was an independent risk factor of all-cause mortality in patients with incident AF. The concomitant diseases that contributed most were found outside the thromboembolic risk scores. The highest relative risk of mortality was seen in women and in the youngest patients compared with controls, and the differences between genders in each age category were statistically significant.

S23109644
Non-traditional risk factors substantially contribute to cardiovascular (CV) disease. A deranged calcium-phosphate metabolism-first identified as a major non-traditional CV risk factor in patients with chronic kidney disease-may be implicated in development and progression of CV disease even among individuals with intact renal function. This review thus summarizes epidemiological and experimental data on the role of calcium, phosphate, and its major regulating hormones-parathyroid hormone, calcitriol, and fibroblast growth factor 23-in CV medicine.

S23396493
PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.

S23257945
Effective population-based interventions are required to reduce the global burden of cardiovascular disease (CVD). Reducing salt intake has emerged as a leading target, with many guidelines recommending sodium intakes of 2.3 g/day or lower. These guideline thresholds are based largely on clinical trials reporting a reduction in blood pressure with low, compared with moderate, intake. However, no large-scale randomized trials have been conducted to determine the effect of low sodium intake on CV events. Prospective cohort studies evaluating the association between sodium intake and CV outcomes have been inconsistent and a number of recent studies have reported an association between low sodium intake (in the range recommended by current guidelines) and an increased risk of CV death. In the largest of these studies, a J-shaped association between sodium intake and CV death and heart failure was found. Despite a large body of research in this area, there are divergent interpretations of these data, with some advocating a re-evaluation of the current guideline recommendations. In this article, we explore potential reasons for the differing interpretations of existing evidence on the association between sodium intake and CVD. Similar to other areas in prevention, the controversy is likely to remain unresolved until large-scale definitive randomized controlled trials are conducted to determine the effect of low sodium intake (compared to moderate intake) on CVD incidence.

S23234645
Our findings from a large population-based cohort highlight detrimental consequences of high adult BMI for lipids as most pronounced for those with a lower BMI at earlier life stages.

S23303661
The prediction of traditional risk factors (systolic blood pressure, total serum cholesterol, and smoking status) on short-term risk (0-10 years) and long-term risk (0-35 years) of CHD of stroke differs substantially. This indicates that the cumulative risk in middle-aged men based on these traditional risk factors can effectively be used to predict CHD but not stroke to the same extent.

S23257951
Decision making with regard to thromboprophylaxis should be based upon the absolute risks of stroke/thromboembolism and bleeding and the net clinical benefit for a given patient. As a consequence, a crucial part of atrial fibrillation (AF) management requires the appropriate use of thromboprophylaxis, and the assessment of stroke as well as bleeding risk can help inform management decisions by clinicians. The objective of this review article is to provide an overview of stroke and bleeding risk assessment in AF. There would be particular emphasis on when, how, and why to use these risk stratification schemes, with a specific focus on the CHADS2 [congestive heart failure, hypertension, age, diabetes, stroke (doubled)], CHA2DS2-VASc [congestive heart failure or left ventricular dysfunction, hypertension, age =75 (doubled), diabetes, stroke (doubled)-vascular disease, age 65-74 and sex category (female)], and HAS-BLED [hypertension (i.e. uncontrolled blood pressure), abnormal renal/liver function, stroke, bleeding history or predisposition, labile INR (if on warfarin), elderly (e.g. age >65, frail condition), drugs (e.g. aspirin, NSAIDs)/alcohol concomitantly] risk scores.

 

FAMILY MEDICINE

 

S23553091
Despite having a robust EHR, we encountered significant challenges finding documentation of depression care, which also made it difficult to track and evaluate the implementation of evidence-based treatment. Clinical documentation in the EHR needs to be simplified and standardized if data extraction and exporting processes of clinician performance data are to become efficient and routine practice.

S23553088
Sexual health is important to the quality of life of aging and older women. Providers can incorporate some of the behaviors identified as enhancing of communication self efficacy so that this important health topic is covered in the clinical encounter

S23553085
Family medicine needs to enhance its scholarly contributions. The discipline is beginning to do so by developing virtuous cycles in which scholarship, education, and clinical care in the patient centered medical home are mutually reinforcing.

S23553089
Academic family physicians acknowledge their lack of knowledge about genetic tests. Educational initiatives may be useful in helping them incorporate genetic testing into practice and in teaching these skills to medical students and residents.

S23553087
Most family medicine training programs want to train their residents in performing EST, but only 36% are doing so. Specifically addressing the barriers to this training will be key to more widespread use of this important test in family medicine settings.

 

FAMILY PRACTICE

 

S22964078
While only statistically near significant, we found some indications of an effect of the intervention compared with usual care. Our results underscore the need for improving GPs' clinical skills in identifying patients with CG.

S23045354
The number of prescribed drugs is the most powerful measure for predicting future consultations and the second most powerful measure for predicting mortality. It may have potential as a simple proxy measure of multimorbidity in primary care.

S23148121
This study provides the first evidence concerning primary care in Austria, benchmarking it as weak and in need of development. The practicable application of an existing assessment tool can be encouraging for other countries to generate evidence about their primary care system as well.

S22997223
A participatory P4P program might stimulate quality improvement in clinical care and improve patient experiences with GP's functioning and the organization of care.

S23097250
12.4% of GP patients presented with WSC. A general symptom may have cancer diagnostic value, but usually, only when it occurs along with a focal symptom. PPV of any single symptom is low, and decisions about referral require additional information.

S23042439
Self-care for back pain is contextualized by the individual's capacity to self-care and preferences for support. Doubt over the ability of GPs to provide support for self-care may mean that those who have specific needs are reticent to seek help. The role of self-care in the management of back pain should be discussed openly at the consultation level, and GPs may be well placed to signpost patients and provide guidance on the safety of specific self-care activities.

S22990026
The program resulted in perceived changes to relationships, teamwork and morale. Addressing issues of leadership, role clarity, empowerment, flattening of hierarchy and teamwork may go a long way in establishing and maintaining a quality culture.

S23024372
This desire of general practice patients for social distance from fellow patients with mental illness may have implications for both the GPs with a particular interest in mental disorders and the care-seeking and access to care of patients with mental illness.

 

GASTROENTEROLOGIA Y HEPATOLOGIA

 

S23522394
La pancreatitis aguda por hipertrigliceridemia es la tercera causa de pancreatitis aguda en la población occidental. Normalmente hay una alteración subyacente del metabolismo lipidémico, sobre la que actúa un factor secundario. La presentación clínica es similar a la de las pancreatitis agudas de otras etiologías, aunque su curso parece ser más tórpido y recurrente. Para su diagnóstico hay que saber que algunos parámetros de la analítica pueden estar artefactados, lo que puede conducir a un fallo en el diagnóstico. Tal es el caso de la amilasa, que puede estar falsamente descendida. El tratamiento se basa en sueroterapia intensa y analgesia. Cuando no responde al tratamiento conservador, deben utilizarse otros métodos para disminuir el nivel de triglicéridos. Para ello disponemos de la plasmaféresis, la insulina y la heparina. Este artículo pretende mostrar una revisión de la literatura actual sobre esta patología.

 

GUT

 

S22698649
Population-based eradication of H pylori infection has led to a significant reduction in gastric atrophy at the expense of increased oesophagitis. The ultimate benefit in reducing gastric cancer incidence and its mortality should be validated by a further long-term follow-up.

S22773548
Use of metformin is associated with a decreased risk of HCC in diabetic patients in a dose-dependent manner, via inhibition of hepatoma cells proliferation and induction of cell cycle arrest at G0/G1 phase.

 

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

 

S23613077
Transvaginal sonography is the single best diagnostic modality for evaluating women with suspected ectopic pregnancy. The presence of abdominal pain or vaginal bleeding during early pregnancy should prompt a transvaginal sonogram and quantitative serum hCG testing.

S23549581
Among patients with painful chemotherapy-induced peripheral neuropathy, the use of duloxetine compared with placebo for 5 weeks resulted in a greater reduction in pain.

S23549586
CLINICAL QUESTION: Which types of interventions reduce falls in older people living in the community? BOTTOM LINE: Fall-prevention exercise programs, usually including muscle strengthening and balance retraining, were associated with lower fall rates in community-dwelling older people whether or not individuals were selected on the basis of fall risk. Home safety interventions, vitamin D supplementation in people with lower vitamin D levels, and individually targeted multifactorial interventions were associated with fewer falls in community-dwelling people with risk factors for falling.

S23592105
The presence of migraine in children and adolescents aged 6 to 18 years was associated with a history of infantile colic. Additional longitudinal studies are required.

S23549585
HIV is no longer a fatal disease. Management of multiple comorbid diseases is a common feature associated with longer life expectancy in HIV-positive patients. There is a need to better understand how to optimize the care of these patients.

S23571590
Advances in understanding the molecular basis of rare and common disorders, as well as in the technology of DNA analysis, are rapidly changing the landscape of molecular genetic and genomic testing. High-resolution molecular cytogenetic analysis can now detect deletions or duplications of DNA of a few hundred thousand nucleotides, well below the resolution of the light microscope. Diagnostic testing for "single-gene" disorders can be done by targeted analysis for specific mutations, by sequencing a specific gene to scan for mutations, or by analyzing multiple genes in which mutation may lead to a similar phenotype. The advent of massively parallel next-generation sequencing facilitates the analysis of multiple genes and now is being used to sequence the coding regions of the genome (the exome) for clinical testing. Exome sequencing requires bioinformatic analysis of the thousands of variants that are identified to find one that is contributing to the pathology; there is also a possibility of incidental identification of other medically significant variants, which may complicate genetic counseling. DNA testing can also be used to identify variants that influence drug metabolism or interaction of a drug with its cellular target, allowing customization of choice of drug and dosage. Exome and genome sequencing are being applied to identify specific gene changes in cancer cells to guide therapy, to identify inherited cancer risk, and to estimate prognosis. Genomic testing may be used to identify risk factors for common disorders, although the clinical utility of such testing is unclear. Genetic and genomic tests may raise new ethical, legal, and social issues, some of which may be addressed by existing genetic nondiscrimination legislation, but which also must be addressed in the course of genetic counseling. The purpose of this article is to assist physicians in recognizing where new approaches to genetic and genomic testing may be applied clinically and in being aware of the principles of interpretation of test results.

S23613074
Maternal use of valproate during pregnancy was associated with a significantly increased risk of autism spectrum disorder and childhood autism in the offspring, even after adjusting for maternal epilepsy. For women of childbearing potential who use antiepileptic medications, these findings must be balanced against the treatment benefits for women who require valproate for epilepsy control.

 

April 14, 2013, marks the 10-year anniversary of the official completion of the entire Human Genome Project.1 This genomics theme issue celebrates recent remarkable advances made possible by one of the greatest biological research projects ever conducted. During the last decade, understanding the complexity of the genome has moved beyond infancy into early childhood, a precarious age of exploration filled with an increasing number of triumphs and the occasional mishap. For the field of genomics, this developmental period has been marked by rapid advances in technologies for dissecting genome function in health and disease. Perhaps most surprisingly, the cost of sequencing the genome has decreased by 5 orders of magnitude through roughly the last 10 years,2 a pace that has exceeded expectations. Many types of basic and clinical studies that would have been unthinkably expensive a decade ago are now quite achievable and proceeding quickly. Reflected in the 2011 strategic vision document authored by the National Human Genome Research Institute is an increasing and welcome trend toward rationally exploring how genomic discoveries affect health

S23632722
Among healthy, term, breastfed infants, only a vitamin D supplement dosage of 1600 IU/d (but not dosages of 400, 800, or 1200 IU/d) increased plasma 25(OH)D concentration to 75 nmol/L or greater in 97.5% of infants at 3 months. However, this dosage increased 25(OH)D concentrations to levels that have been associated with hypercalcemia.

S23592106
Among a sample of patients with a CHD or stroke event from countries with varying income levels, the prevalence of healthy lifestyle behaviors was low, with even lower levels in poorer countries.

S23538438
More than a million hospitalizations for heart failure (HHF) occur annually in the United States, with mortality and readmission rates up to 50% within 60 to 90 days after discharge. The annual costs for HF care exceed $40 billion, with the majority spent on HHF. Hospital reimbursement is now tied to 30-day readmission rates among patients with HF.1 Most HHF patients have worsening chronic HF and are receiving recommended therapies. Despite improved signs or symptoms by discharge, postdischarge event rates remain high. About half of the HHF patients have preserved left ventricular ejection fraction for which there is no evidence-based treatment.

S23632723
Among girls who received 2 doses of HPV vaccine 6 months apart, responses to HPV-16 and HPV-18 one month after the last dose were noninferior to those among young women who received 3 doses of the vaccine within 6 months. Because of the loss of noninferiority to some genotypes at 24 to 36 months in girls given 2 doses vs 3 doses, more data on the duration of protection are needed before reduced-dose schedules can be recommended.

S23632725
Of children born extremely preterm and receiving active perinatal care, 73% had mild or no disability and neurodevelopmental outcome improved with each week of gestational age. These results are relevant for clinicians counseling families facing extremely preterm birth.

 

JAMA INTERNAL MEDICINE

 

S23440284
In this administrative database study of US adults with type 2 diabetes mellitus, treatment with the GLP-1-based therapies sitagliptin and exenatide was associated with increased odds of hospitalization for acute pancreatitis.

S23460396
On the basis of short-term RCTs that enrolled highly selected populations with long-term high-moderate to very severe symptoms, dopamine agonists and calcium channel alpha-2-delta ligands reduced RLS symptoms and improved sleep outcomes and disease-specific quality of life. Adverse effects and treatment withdrawals due to adverse effects were common.

S23529078
Selective reporting biases may be common in the evidence on emerging cardiovascular biomarkers. Most of the proposed associations of these biomarkers may be inflated.

S23478904 
Although the absolute risk of complications is low, the use of anesthesia services for colonoscopy is associated with a somewhat higher frequency of complications, specifically, aspiration pneumonia. The differences may result in part from uncontrolled confounding, but they may also reflect the impairment of normal patient responses with the use of deep sedation.

 

JAMA PSYCHIATRY

 

S23426798
The effects of being bullied are direct, pleiotropic, and long-lasting, with the worst effects for those who are both victims and bullies.

 

MEDICINA CLINICA

 

S23339888
Parece que el QFT, solo o combinado con la PT, es un método seguro para el diagnóstico de la ILT y que su utilización contribuiría a una selección más específica de los individuos que necesitan un tratamiento preventivo.

S22595253
La determinación del IDB aporta información adicional a la determinación del ITB y puede ser una exploración muy útil en caso de calcificación arterial. El valor inferior o igual a 0,60 es el más adecuado para considerar un IDB patológico.

S22726769
El ICT resultó ser un buen marcador del sobrepeso y la obesidad en niños entre los 6 y 14 años. Los puntos de corte que identifican la obesidad son 0,51 en los varones y 0,50 en las niñas. Para el sobrepeso, oscilan entre 0,47 y 0,48 dependiendo del sexo y la variable tomada como criterio.

S22575556
El 51,6% eran mujeres y la media de edad era de 66,2 años. Se observó una prevalencia de ERC del 23,2%, con 108 casos (21,6%) en estadio 3 y 8 (1,6%) en estadio 4, sin ningún paciente en estadio 5. Un 70,4% eran hipertensos, un 67% tenían dislipidemia, el 17,6% eran fumadores y el 19% tenían antecedente de ECV (46% de ellos, cardiopatía isquémica). La presencia de ERC se relacionó con más edad, sexo femenino, creatinina plasmática elevada, presencia de microabuminuria y antecedentes de tabaquismo activo, HTA, dislipidemia y ECV. Al analizar los datos según las categorías de ERC, desaparecía la relación significativa con el tabaquismo. En el análisis multivariado existía relación positiva con edad, sexo femenino, dislipidemia y cardiopatía isquémica.

S22498350
Se proporciona información por primera vez sobre la carga de enfermedad en la población valenciana. A este nivel local, el uso de los AVAD puede ayudar a monitorizar el estado de salud de la población y guiar los debates sobre el establecimiento de prioridades.

S23177309
Hasta en un 14% de los pacientes que presentan un síndrome coronario agudo (SCA) no se detectan obstrucciones coronarias. Frecuentemente el diagnóstico de la causa subyacente no se establece y existe controversia en cuanto al pronóstico. Los pacientes con SCA y coronarias normales o sin lesiones angiográficamente significativas son más frecuentemente mujeres, de edad joven y con menor incidencia de factores de riesgo cardiovascular (FRCV). Clásicamente el pronóstico ha sido excelente, aunque en los últimos años diferentes resultados demuestran una evolución no tan benigna. Esto podría explicarse por los diferentes grados de lesiones coronarias, la presentación clínica, la movilización de biomarcadores o los FRCV. Es necesario establecer la causa del SCA y estratificar el riesgo de estos pacientes para instaurar un tratamiento adecuado, especialmente en los casos de enfermedad coronaria no detectada por angiografía, donde la ausencia de tratamiento específico puede condicionar un peor pronóstico.

 

MORBIDITY AND MORTALITY WEEKLY REPORT

 

S23515099
Meningococcal disease describes the spectrum of infections caused by Neisseria meningiditis, including meningitdis, bacteremia, and bacteremic pneumonia. Two quadrivalent meningococcal polysaccharide-protein conjugate vaccines that provide protection against meningococcal serogroups A, C, W, and Y (MenACWY-D [Menactra, manufactured by Sanofi Pasteur, Inc., Swiftwater, Pennsylvania] and MenACWY-CRM [Menveo, manufactured by Novartis Vaccines, Cambridge, Massachusetts]) are licensed in the United States for use among persons aged 2 through 55 years. MenACWY-D also is licensed for use among infants and toddlers aged 9 through 23 months. Quadrivalent meningococcal polysaccharide vaccine (MPSV4 [Menommune, manufactured by sanofi pasteur, Inc., Swiftwater, Pennsylvania]) is the only vaccine licensed for use among persons aged ≥56 years. A bivalent meningococcal polysaccharide protein conjugate vaccine that provides protection against meningococcal serogroups C and Y along with Haemophilus influenzae type b (Hib) (Hib-MenCY-TT [MenHibrix, manufactured by GlaxoSmithKline Biologicals, Rixensart, Belgium]) is licensed for use in children aged 6 weeks through 18 months. This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of meningococcal disease in the United States, specifically the changes in the recommendations published since 2005 (CDC. Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2005;54 [No. RR-7]). As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations; it is intended for use by clinicians as a resource. ACIP recommends routine vaccination with a quadrivalent meningococcal conjugate vaccine (MenACWY) for adolescents aged 11 or 12 years, with a booster dose at age 16 years. ACIP also recommends routine vaccination for persons at increased risk for meningococcal disease (i.e., persons who have persistent complement component deficiencies, persons who have anatomic or functional asplenia, microbiologists who routinely are exposed to isolates of N. meningitidis, military recruits, and persons who travel to or reside in areas in which meningococcal disease is hyperendemic or epidemic). Guidelines for antimicrobial chemoprophylaxis and for evaluation and management of suspected outbreaks of meningococcal disease also are provided.

 

REVISTA ESPAÑOLA DE CARDIOLOGIA

 

S23375996
La prevalencia de sobrepeso y obesidad infantil y juvenil en España sigue siendo muy alta (cercana al 40%), pero no ha crecido en los últimos 12 años.

 

THE LANCET

 

S23541057
The ageing of European populations presents health, long-term care, and welfare systems with new challenges. Although reports of ageing as a fundamental threat to the welfare state seem exaggerated, societies have to embrace various policy options to improve the robustness of health, long-term care, and welfare systems in Europe and to help people to stay healthy and active in old age. These policy options include prevention and health promotion, better self-care, increased coordination of care, improved management of hospital admissions and discharges, improved systems of long-term care, and new work and pension arrangements. Ageing of the health workforce is another challenge, and policies will need to be pursued that meet the particular needs of older workers (ie, those aged 50 years or older) while recruiting young practitioners.

S23414650
Guidelines are needed to reduce the referral rate after CTC. For most patients, however, CTC provides a similarly sensitive, less invasive alternative to colonoscopy.

S23369797
Severe ALRI is a substantial burden on health services worldwide and a major cause of hospital referral and admission in young children. Improved hospital access and reduced inequities, such as those related to sex and rural status, could substantially decrease mortality related to such infection. Community-based management of severe disease could be an important complementary strategy to reduce pneumonia mortality and health inequities.

S23541056
Western European health systems are not keeping pace with changes in child health needs. Non-communicable diseases are increasingly common causes of childhood illness and death. Countries are responding to changing needs by adapting child health services in different ways and useful insights can be gained through comparison, especially because some have better outcomes, or have made more progress, than others. Although overall child health has improved throughout Europe, wide inequities remain. Health services and social and cultural determinants contribute to differences in health outcomes. Improvement of child health and reduction of suffering are achievable goals. Development of systems more responsive to evolving child health needs is likely to necessitate reconfiguring of health services as part of a whole-systems approach to improvement of health. Chronic care services and first-contact care systems are important aspects. The Swedish and Dutch experiences of development of integrated systems emphasise the importance of supportive policies backed by adequate funding. France, the UK, Italy, and Germany offer further insights into chronic care services in different health systems. First-contact care models and the outcomes they deliver are highly variable. Comparisons between systems are challenging. Important issues emerging include the organisation of first-contact models, professional training, arrangements for provision of out-of-hours services, and task-sharing between doctors and nurses. Flexible first-contact models in which child health professionals work closely together could offer a way to balance the need to provide expertise with ready access. Strategies to improve child health and health services in Europe necessitate a whole-systems approach in three interdependent systems-practice (chronic care models, first-contact care, competency standards for child health professionals), plans (child health indicator sets, reliable systems for capture and analysis of data, scale-up of child health research, anticipation of future child health needs), and policy (translation of high-level goals into actionable policies, open and transparent accountability structures, political commitment to delivery of improvements in child health and equity throughout Europe).

S23541059
The financial crisis in Europe has posed major threats and opportunities to health. We trace the origins of the economic crisis in Europe and the responses of governments, examine the effect on health systems, and review the effects of previous economic downturns on health to predict the likely consequences for the present. We then compare our predictions with available evidence for the effects of the crisis on health. Whereas immediate rises in suicides and falls in road traffic deaths were anticipated, other consequences, such as HIV outbreaks, were not, and are better understood as products of state retrenchment. Greece, Spain, and Portugal adopted strict fiscal austerity; their economies continue to recede and strain on their health-care systems is growing. Suicides and outbreaks of infectious diseases are becoming more common in these countries, and budget cuts have restricted access to health care. By contrast, Iceland rejected austerity through a popular vote, and the financial crisis seems to have had few or no discernible effects on health. Although there are many potentially confounding differences between countries, our analysis suggests that, although recessions pose risks to health, the interaction of fiscal austerity with economic shocks and weak social protection is what ultimately seems to escalate health and social crises in Europe. Policy decisions about how to respond to economic crises have pronounced and unintended effects on public health, yet public health voices have remained largely silent during the economic crisis.

S23582727
Diarrhoea and pneumonia are the leading infectious causes of childhood morbidity and mortality. We comprehensively reviewed the epidemiology of childhood diarrhoea and pneumonia in 2010-11 to inform the planning of integrated control programmes for both illnesses. We estimated that, in 2010, there were 1·731 billion episodes of diarrhoea (36 million of which progressed to severe episodes) and 120 million episodes of pneumonia (14 million of which progressed to severe episodes) in children younger than 5 years. We estimated that, in 2011, 700,000 episodes of diarrhoea and 1·3 million of pneumonia led to death. A high proportion of deaths occurs in the first 2 years of life in both diseases--72% for diarrhoea and 81% for pneumonia. The epidemiology of childhood diarrhoea and that of pneumonia overlap, which might be partly because of shared risk factors, such as undernutrition, suboptimum breastfeeding, and zinc deficiency. Rotavirus is the most common cause of vaccine-preventable severe diarrhoea (associated with 28% of cases), and Streptococcus pneumoniae (18·3%) of vaccine-preventable severe pneumonia. Morbidity and mortality from childhood pneumonia and diarrhoea are falling, but action is needed globally and at country level to accelerate the reduction.

S23541053
Europe, with its 53 countries and divided history, is a remarkable but inadequately exploited natural laboratory for studies of the eff ects of health policy. In this paper, the fi rst in a Series about health in Europe, we review developments in population health in Europe, with a focus on trends in mortality, and draw attention to the main successes and failures of health policy in the past four decades. In western Europe, life expectancy has improved almost continuously, but progress has been erratic in eastern Europe, and, as a result, disparities in male life expectancy between the two areas are greater now than they were four decades ago. The falls in mortality noted in western Europe are associated with many different causes of death and show the combined eff ects of economic growth, improved health care, and successful health policies (eg, tobacco control, road traffic safety). Less favourable mortality trends in eastern Europe show economic and health-care problems and a failure to implement effective health policies. The political history of Europe has left deep divisions in the health of the population. Important health challenges remain in both western and eastern Europe and signify unresolved issues in health policy (eg, alcohol, food) and rising health inequalities within countries.

S23642700
Smoking is prevalent across Europe, but the severity and stage of the smoking epidemic, and policy responses to it, vary substantially between countries. Much progress is now being made in prohibition of paid-for advertising and in promotion of smoke-free policies, but mass media campaigns are widely underused, provision of services for smokers trying to quit is generally poor, and price policies are undermined by licit and illicit cheap supplies. Monitoring of prevalence is inadequate in many countries, as is investment in research and capacity to address this largest avoidable cause of death and disability across Europe. However, grounds for optimism are provided by progress in implementation of the WHO Framework Convention on Tobacco Control, and in the development of a new generation of nicotine-containing devices that could enable more widespread adoption of harm-reduction strategies. The effect of commercial vested interests has been and remains a major barrier to progress.

S23415013
Use of clopiogrel without aspirin was associated with a significant reduction in bleeding complications and no increase in the rate of thrombotic events.

S23642698
The USA has a rich history of public health efforts to reduce morbidity and mortality from tobacco use. Comprehensive tobacco-prevention programmes, when robustly implemented, reduce the prevalence of youth and adult smoking, decrease cigarette consumption, accelerate declines in tobacco-related deaths, and diminish health-care costs from tobacco-related diseases. Effective public health interventions include raising the price of tobacco products, smoke-free policies, counter-marketing campaigns, advertising restrictions, augmenting access to treatment for tobacco use through insurance coverage and telephone help lines, and comprehensive approaches to prevent children and adolescents from accessing tobacco products. The US Food and Drug Administration (FDA) has six major areas of regulatory authority: regulation of tobacco products; regulation of the advertising, marketing, and promotion of tobacco products; regulation of the distribution and sales of tobacco products; enforcement of the provisions of the Tobacco Control Act and tobacco regulations; regulatory science to support FDA authorities and activities; and public education about the harms of tobacco products and to support FDA regulatory actions. With passing of the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act) in June, 2009, important new regulatory approaches were added to the tobacco prevention and control arsenal.

 

THE NEW ENGLAND JOURNAL OF NEDICINE

 

S23614587
Although there were improvements in risk-factor control and adherence to preventive practices from 1999 to 2010, tobacco use remained high, and almost half of U.S. adults with diabetes did not meet the recommended goals for diabetes care (Funded by Boehringer Ingelheim; ClinicalTrials.gov number, NCT00623623.).

S23473396
Prehospital fibrinolysis with timely coronary angiography resulted in effective reperfusion in patients with early STEMI who could not undergo primary PCI within 1 hour after the first medical contact. However, fibrinolysis was associated with a slightly increased risk of intracranial bleeding.

Our findings were statistically inconclusive. In patients with metastatic hormone-sensitive prostate cancer, the confidence interval for survival exceeded the upper boundary for noninferiority, suggesting that we cannot rule out a 20% greater risk of death with intermittent therapy than with continuous therapy, but too few events occurred to rule out significant inferiority of intermittent therapy. Intermittent therapy resulted in small improvements in quality of life. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00002651.).

S23635049
In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped. (Funded by Action Medical Research; PATCH I Controlled-Trials.com number, ISRCTN34716921.)

S23550669
Our findings were statistically inconclusive. In patients with metastatic hormone-sensitive prostate cancer, the confidence interval for survival exceeded the upper boundary for noninferiority, suggesting that we cannot rule out a 20% greater risk of death with intermittent therapy than with continuous therapy, but too few events occurred to rule out significant inferiority of intermittent therapy. Intermittent therapy resulted in small improvements in quality of life. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00002651.).

S23550670
Dementia represents a substantial financial burden on society, one that is similar to the financial burden of heart disease and cancer. (Funded by the National Institute on Aging.).

S23432189
Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events. (Funded by the Spanish government's Instituto de Salud Carlos III and others; Controlled-Trials.com number, ISRCTN35739639.).

S23635050
Azithromycin use was not associated with an increased risk of death from cardiovascular causes in a general population of young and middle-aged adults. (Funded by the Danish Medical Research Council.).

S23506518
In the intention-to-treat analysis, we did not find significant differences between the study groups in functional improvement 6 months after randomization; however, 30% of the patients who were assigned to physical therapy alone underwent surgery within 6 months. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases; METEOR ClinicalTrials.gov number, NCT00597012.).

 

THORAX

 

S23291349
Azithromycin did not reduce the rate of severe exacerbations and LRTI in patients with severe asthma. However, the significant reduction in the PEP rate in azithromycin-treated patients with non-eosinophilic severe asthma warrants further study.

S22781122
Despite intensive research efforts, the aetiology of the majority of chronic lung diseases (CLD) in both, children and adults, remains elusive. Current therapeutic options are limited, providing only symptomatic relief, rather than treating the underlying condition, or preventing its development in the first place. Thus, there is a strong and unmet clinical need for the development of both, novel effective therapies and preventative strategies for CLD. Many studies suggest that modifications of prenatal and/or early postnatal lung development will have important implications for future lung function and risk of CLD throughout life. This view represents a fundamental change of current pathophysiological concepts and treatment paradigms, and holds the potential to develop novel preventative and/or therapeutic strategies. However, for the successful development of such approaches, key questions, such as a clear understanding of underlying mechanisms of impaired lung development, the identification and validation of relevant preclinical models to facilitate translational research, and the development of concepts for correction of aberrant development, all need to be solved. Accordingly, a European Science Foundation Exploratory Workshop was held where clinical, translational and basic research scientists from different disciplines met to discuss potential mechanisms of developmental origins of CLD, and to identify major knowledge gaps in order to delineate a roadmap for future integrative research.

S23299962
This large cohort study did not find an association between statin use and the incidence of ILD.

S23319429
If the association between fast foods and the symptom prevalence of asthma, rhinoconjunctivitis and eczema is causal, then the findings have major public health significance owing to the rising consumption of fast foods globally.

 

 

 

 

                      

 

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