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Agosto 2014 PDF Imprimir E-mail
Lunes, 08 de Septiembre de 2014 00:00

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SELECCIÓN DE REFERENCIAS BIBLIOGRÁFICAS DE LO PUBLICADO EN RELACIÓN CON ATENCIÓN PRIMARIA

Selección realizada por Antonio Manteca González
 
 
 
Riess H, Kraft-Todd G. E.m.p.a.T.h.y.: a tool to enhance nonverbal communication between clinicians and their patients. Acad Med 2014;89:1108-1112 [T,I]
24826853             R/C
E.M.P.A.T.H.Y.: HERRAMIENTA PARA FORTALECER LA COMUNICACIÓN NO VERBAL ENTRE LOS CLÍNICOS Y SUS PACIENTES
 
Rothberg MB, Kleppel R, Friderici JL, Hinchey K. Implementing a resident research program to overcome barriers to resident research. Acad Med 2014;89:1133-1139 [QE,I]
24751975             R/C
PUESTA EN MARCHA DE UN PROGRAMA DE INVESTIGACIÓN PARA RESIDENTES PARA VENCER LAS BARRERAS A LA INVESTIGACIÓN EN LOS RESIDENTES
 
 
Diagnosis of obstructive sleep apnea in adults: a clinical practice guideline from the american college of physicians. Ann Intern Med 2014;161 [M,II]
DIAGNÓSTICO DE LA APNEA OBSTRUCTIVA DEL SUEÑO EN ADULTOS
 
Rhon DI, Boyles RB, Cleland JA. One-year outcome of subacromial corticosteroid injection compared with manual physical therapy for the management of the unilateral shoulder impingement syndrome: a pragmatic randomized trial. Ann Intern Med 2014;161:161-169 [EC,I]
25089860             R/C
RESULTADOS EN UN AÑO DE LA INYECCIÓN SUBACROMIAL DE CORTICOIDES COMPARADA CON LA TERAPIA FÍSICA MANUAL EN EL TRATAMIENTO DEL SÍNDROME DE PINZAMIENTO UNILATERAL DEL HOMBRO: ENSAYO ALEATORIZADO PRAGMÁTICO
 
Kabiri M, Jazwinski AB, Roberts MS, Schaefer AJ, Chhatwal J. The changing burden of hepatitis C virus infection in the United States: model-based predictions. Ann Intern Med 2014;161:170-180 [T,II]
25089861             R/C
LA CARGA CAMBIANTE DE INFECCIÓN POR EL VIRUS DE LA HEPATITIS C EN LOS EE UU: PREDICCIONES MEDIANTE MODELO
 
 
Fernández-Liz E, Romero MR. Antiinflamatorios no esteroideos y riesgo cardiovascular: implicaciones para la práctica clínica. Aten Primaria 2014;46:323-325 [AO,I]
ANTIINFLAMATORIOS NO ESTEROIDEOS Y RIESGO CARDIOVASCULAR: IMPLICACIONES PARA LA PRÁCTICA CLÍNICA
 
Suárez C, Del Moral G, Musitu G, Sánchez JC, John B. Eficacia de las políticas institucionales de prevención del consumo de alcohol en adolescentes: la opinión de expertos y adolescentes. Aten Primaria 2014;46:326-335 [C,I]
24768656             R/C
EFICACIA DE LAS POLÍTICAS INSTITUCIONALES DE PREVENCIÓN DEL CONSUMO DE ALCOHOL EN ADOLESCENTES: LA OPINIÓN DE EXPERTOS Y ADOLESCENTES
 
Párraga I, López-Torres J, Del Campo JM, Villena A, Morena S, Escobar F; en representación del Grupo ADSCAMFYC. Seguimiento de la adherencia al tratamiento antidepresivo en pacientes que inician su consumo. Aten Primaria 2014;46:357-366 [S,I]
24704196             R/C
SEGUIMIENTO DE LA ADHERENCIA AL TRATAMIENTO ANTIDEPRESIVO EN PACIENTES QUE INICIAN SU CONSUMO
 
Sánchez M, Blanco A, Castell MV, Gutiérrez A, González JI, Zunzunegui MV, et al. Diabetes en personas mayores: prevalencia, incidencia y su asociación con la mortalidad general a medio y largo plazo. Aten Primaria 2014;46:376-384 [S,I]
24576691             R/C
DIABETES EN PERSONAS MAYORES: PREVALENCIA, INCIDENCIA Y SU ASOCIACIÓN CON LA MORTALIDAD GENERAL A MEDIO Y LARGO PLAZO
 
Bernabeu-Wittel M, Alonso-Coello P, Rico-Blázquez M, Rotaeche R, Sánchez S, Casariego E. Desarrollo de guías de práctica clínica en pacientes con comorbilidad y pluripatología. Aten Primaria 2014;46:385-392 [M,II]
24968962             R/C
DESARROLLO DE GUÍAS DE PRÁCTICA CLÍNICA EN PACIENTES CON COMORBILIDAD Y PLURIPATOLOGÍA
 
 
Ninan S, Walton C, Barlow G. Investigation of suspected urinary tract infection in older people. BMJ 2014;349:g4070 [R,I]
INVESTIGACIÓN DE SOSPECHA DE INFECCIÓN DE VÍAS URINARIAS BAJAS EN PERSONAS MAYORES
 
Jones I, Shakespeare J. Postnatal depression. BMJ 2014;349:g4500 [R,I]
DEPRESIÓN POSTPARTO
 
Hippisley-Cox J, Coupland C. Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores. BMJ 2014;349:g4606 [S,II]
25069704             R/C
PREDECIR EL RIESGO DE HEMORRAGIA DIGESTIVA ALTA Y SANGRADO INTRACRANEAL CON LOS ANTICOAGULANTES: ESTUDIO DE COHORTE PARA CALCULAR Y VALIDAR LAS TABLAS QBLEED
 
Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S, et al. Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis. BMJ 2014;349:g4643 [M,II]
25097193             R/C
EFECTO DE LA VACUNA BCG CONTRA LA INFECCIÓN POR MYCOBACTERIUM TUBERCULOSIS EN NIÑOS: REVISIÓN SISTEMÁTICA Y METAANÁLISIS
 
Furyk JS, Meek R, McKenzie S. Drug treatment of adults with nausea and vomiting in primary care. BMJ 2014;349:g4714 [R,I]
TRATAMIENTO FARMACOLÓGICO DE LOS ADULTOS CON NÁUSEAS Y VÓMITOS EN ATENCIÓN PRIMARIA
 
Nair KP, Marsden J. The management of spasticity in adults. BMJ 2014;349:g4737 [R,I]
MANEJO DE LA ESPASTICIDAD EN ADULTOS
 
Prue G. Vaccinate boys as well as girls against HPV: it works, and it may be cost effective. BMJ 2014;349:g4834. [AO,I]
VACUNAR TANTO A LOS CHICOS COMO A LAS CHICAS CONTRA EL VPH: FUNCIONA Y PUEDE SER RENTABLE
 
Svanström H, Pasternak B, Hviid A. Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study. BMJ 2014;349:g4930 [S,I]
25139799             R/C
USO DE CLARITROMICINA Y ROXITROMICINA Y RIESGO DE MUERTE CARDIACA: ESTUDIO DE COHORTE
 
Tan K, Petrie KJ, Faasse K, Bolland MJ, Grey A. Unhelpful information about adverse drug reactions. BMJ 2014;349:g5019 [R,I]
INFORMACIÓ INÚTIL SOBRE REACCIONES FARMACOLÓGICAS ADVERSAS
 
Godlle F. Too much information. BMJ 2014;349:g5153 [AO,I]
DEMASIADA INFORMACIÓN
 
Jackson T. Mental health: a worthwhile goal BMJ 2014;349:g5249 [AO,I]
SALUD MENTAL: OBJETIVO MUNDIAL
 
 
Patrick K. Patients and their medical records: It is time to embrace transparency. CMAJ 2014;186:811 [AO,I]
LOS PACIENTES Y SUS REGISTROS MÉDICOS: ES HORA DE ACEPTAR LA TRANSPARENCIA
 
Squissato V, Brown G. Carpal tunnel syndrome. CMAJ 2014;186:853 [R,I]
SÍNDROME DEL TÚNEL CARPIANO
 
Gorman DA, Abi-Jaoude E. Obsessive-compulsive disorder. CMAJ 2014;186:E435 [R,I]
TRASTORNO OBSESIVO-COMPULSIVO
 
 
Sollid ST, Hutchinson MY, Fuskevåg OM, Figenschau Y, Joakimsen RM, Schirmer H, et al. No effect of high-dose vitamin D supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes. Diabetes Care 2014;37:2123-2131 [EC,I]
24947792             R/C
FALTA DE EFECTO DE LOS SUPLEMENTOS DE VITAMINA D EN ALTAS DOSIS SOBRE EL ESTADO GLUCÉMICO Y LOS FACTORES DE RIESGO CARDIOVASCULAR EN SUJETOS CON PREDIABETES
 
Nauck M, Weinstock RS, Umpierrez GE, Guerci B, Skrivanek Z, Milicevic Z. Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5). Diabetes Care 2014;37:2149-2158 [EC,I]
24742660             R/C
EFICACIA Y SEGURIDAD DE LA DULAGLUTIDA FRENTE A LA SITAGLIPTINA EN LA DIABETES TIPO 2 TRAS 52 SEMANAS EN UN ENSAYO CONTROLADO ALEATORIZADO (AWARD-5)
 
Umpierrez G, Tofé S, Pérez F, Shurzinske L, Pechtner V. Efficacy and safety of dulaglutide monotherapy versus metformin in type 2 diabetes in a randomized controlled trial (AWARD-3). Diabetes Care 2014;37:2168-2176 [EC,I]
24842985             R/C
EFICACIA Y SEGURIDAD DE LA MONOTERPIA CON DULAGLUTIDA FRENTE A METFORMINA EN LA DIABETES TIPO 2 EN UN ENSAYO CONTROLADO ALEATORIZADO (AWARD-3)
 
Laake JP, Stahl D, Amiel SA, Petrak F, Sherwood RA, Pickup JC, et al. The association between depressive symptoms and systemic inflammation in people with type 2 diabetes: findings from the South London Diabetes study. Diabetes Care 2014;37:2186-2192 [T,I]
24842983             R/C
ASOCIACIÓN ENTRE SÍNTOMAS DEPRESIVOS E INFLAMACIÓN SISTÉMICA EN PERSONAS CON DIABETES TIPO 2: HALLAZGOS DEL ESTUDIO SOUTH LONDON DIABETES
 
Eppenga WL, Lalmohamed A, Geerts AF, Derijks HJ, Wensing M, Egberts A, et al. Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. Diabetes Care 2014;37:2218-2224 [S,I]
24842984             R/C
RIESGO DE ACIDOSIS LÁCTICA O CONCENTRACIONES ELEVADAS DE LACTATO EN USUARIOS DE METFORMINA CON ALTERACIÓN RENAL: ESTUDIO DE COHORTE POBLACIONAL
 
Corrao G, Ibrahim B, Nicotra F, Soranna D, Merlino L, Catapano AL, et al. Statins and the risk of diabetes: evidence from a large population-based cohort study. Diabetes Care 2014;37:2225-2232 [S,I]
24969582             R/C
ESTATINAS Y RIESGO DE DIABETES: EVIDENCIAS DE UN GRAN ESTUDIO DE COHORTE POBLACIONAL
 
Richy FF, Sabidó-Espin M, Guedes S, Corvino FA, Gottwald-Hostalek U. Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study. Diabetes Care 2014;37:2291-2295 [S,II]
24879835             R/C
INCIDENCIA DE ACIDOSIS LÁCTICA EN PACIENTES CON DIABETES TIPO 2 CON Y SIN ALTERACIÓN RENAL TRATADOS CON METFORMINA: ESTUDIO DE COHORTE RETROSPECTIVO
 
Hirakawa Y, Arima H, Zoungas S, Ninomiya T, Cooper M, Hamet P, et al. Impact of visit-to-visit glycemic variability on the risks of macrovascular and microvascular events and all-cause mortality in type 2 diabetes: the ADVANCE trial. Diabetes Care 2014;37:2359-2365 [EC,II]
24812434             R/C
IMPACTO DE LA VARIABIIDAD GLUCÉMICA DE VISITA A VISITA SOBRE LOS RIESGOS DE ACONTECIMIENTOS MACRO Y MICROVASCULARES Y LA MORTALIDAD POR CUALQUIER CAUSA EN LA DIABETES TIPO 2: ENSAYO ADVANCE
 
 
Amarasinghe G, Sifrim D. Functional esophageal disorders: pharmacological options. Drugs 2014;74:1335-1344 [R,I]
25103415             R/C
TRASTORNOS FUNCIONALES DEL ESÓFAGO: OPCIONES FARMACOLÓGICAS
 
 
Plouvier AO, Hameleers RJ, van den Heuvel EA, Bor HH, Olde Hartman TC, Bloem BR, et al. Prodromal symptoms and early detection of Parkinson's disease in general practice: a nested case-control study. Fam Pract 2014;31:373-378 [CC,II]
24869632             R/C
SÍNTOMAS PRODRÓMICOS Y DETECCIÓN PRECOZ DE LA ENFERMEDAD DE PARKINSON EN MEDICINA GENERAL: ESTUDIO CASO-CONTROL ANIDADO
 
Ramond-Roquin A, Bouton C, Gobin-Tempereau AS, Airagnes G, Richard I, Roquelaure Y, et al. Interventions focusing on psychosocial risk factors for patients with non-chronic low back pain in primary care-a systematic review. Fam Pract 2014;31:379-388 [M,II]
24632524             R/C
INTERVENCIONES CENTRADAS EN LOS FACTORES DE RIESGO PSICOSOCIAL EN PACIENTES CON LUMBALGIA NO CRÓNICA EN ATENCIÓN PRIMARIA-REVISIÓN SISTEMÁTICA
 
Sinclair JE, Aucott LS, Lawton K, Reid IC, Cameron IM. The monitoring of longer term prescriptions of antidepressants: observational study in a primary care setting. Fam Pract 2014;31:419-426 [S,II]
24850795             R/C
MONITORIZACIÓN DE LAS PRESCRIPCIONES A LARGO PLAZO DE ANTIDEPRESIVOS: ESTUDIO OBSERVACIONAL EN EL ÁMBITO DE LA ATENCIÓN PRIMARIA
 
Gelly J, Le Bel J, Aubin-Auger I, Mercier A, Youssef E, Mentre F, et al; ECOGEN study group. Profile of French general practitioners providing opportunistic primary preventive care-an observational cross-sectional multicentre study. Fam Pract 2014;31:445-452 [T,I]
24925928             R/C
PERFIL DE LOS MÉDICOS GENERALES FRANCESES QUE PROPORCIONAN ATENCIÓN OPORTUNÍSTICA DE PREVENCIÓN PRIMARIA-ESTUDIO OBSERVACIONAL TRANSVERSAL MULTICÉNTRICO
 
Dunne SS, Shannon B, Cullen W, Dunne CP. Beliefs, perceptions and behaviours of GPs towards generic medicines. Fam Pract 2014;31:467-474 [C,I]
24895136             R/C
CREENCIAS, PERCEPCIONES Y COMPORTAMIENTOS DE LOS MÉDICOS GENERALES RESPECTO A LOS MEDICAMENTOS GENÉRICOS
 
Carey M, Jones KA, Yoong SL, D'Este C, Boyes AW, Paul C, et al. Comparison of a single self-assessment item with the PHQ-9 for detecting depression in general practice. Fam Pract 2014 [Epub ahead of print] [T,I]
24839267             R/C
COMPARACIÓN DE UN CUESTIONARIO DE AUTOVALORACIÓN SENCILLA CON RESPECTO AL PHQ-9 PARA DETECTAR DEPRESIÓN EN MEDICINA GENERAL
 
 
Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, et al; Authors of the BSG Coeliac Disease Guidelines Development Group. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut 2014;63:1210-1228 [M,II]
24917550             R/C
DIAGNÓSTICO Y MANEJO DE LA ENFERMEDAD CELÍACA DEL ADULTO: PAUTAS DE LA BRITISH SOCIETY OF GASTROENTEROLOGY
 
Kim GA, Lim YS, An J, Lee D, Shim JH, Kim KM, et al. HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability. Gut 2014;63:1325-1332 [S,I]
24162593             R/C
ACLARAMIENTO SÉRICO DEL HBsAg TRAS TERAPIA CON ANÁLOGOS DE NUCLEÓSIDOS EN PACIENTES CON HEPATITIS B CRÓNICA: RESULTADOS CLÍNICOS Y PERSISTENCIA
 
 
Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, et al. Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial. JAMA 2014;312:606-615 [EC,II]
25117129             R/C
EFECTO DEL CRIBAJE CON SIGMOIDOSCOPIO FLEXIBLE SOBRE LA INCIDENCIA Y MORTALIDAD POR CÁNCER COLORRECTAL: ENSAYO CLÍNICO ALEATORIZADO
 
Gostin LO, Glasner AY. E-cigarettes, vaping, and youth. JAMA 2014;312:595-596 [AO,I]
CIGARRILLOS ELECTRÓNICOS, VAPEO Y JUVENTUD
 
Brett AS. Flexible sigmoidoscopy for colorectal cancer screening: more evidence, persistent ironies. JAMA 2014;312:601-602 [AO,I]
SIGMOIDOSCOPIA FLEXIBLE PARA EL CRIBAJE DE CÁNCER COLORRECTAL: MÁS EVIDENCIA, IRONÍAS PERSISTENTES
 
Makris UE, Abrams RC, Gurland B, Reid MC. Management of persistent pain in the older patient: a clinical review. JAMA 2014;312:825-836 [R,II]
25157726             R/C
MANEJO DEL DOLOR PERSISTENTE EN EL PACIENTE ANCIANO: REVISIÓN CLÍNICA
 
Brennan T, Shrank W. New expensive treatments for hepatitis C infection. JAMA 2014;312:593-594 [AO,I]
NUEVOS Y CAROS TRATAMIENTOS PARA LA INFECCIÓN DE HEPATITIS C
 
Song Z, Sequist TD, Barnett ML. Patient referrals: a linchpin for increasing the value of care. JAMA 2014;312:597-598 [AO,I]
DERIVACIONES DE PACIENTES: EL EJE PARA INCREMENTAR EL VALOR DE LA ATENCIÓN
 
Gini G, Espelage DL. Peer victimization, cyberbullying, and suicide risk in children and adolescents. JAMA 2014;312:545-546 [AO,I]
VICTIMIZACIÓN POR LOS COMPAÑEROS, CIBERACOSO Y RIESGO DE SUICIDIO EN NIÑOS Y ADOLESCENTES
 
Hingson R, Compton WM. Screening and brief intervention and referral to treatment for drug use in primary care: back to the drawing board. JAMA 2014;312:488-489 [AO,I]
CRIBAJE, INTERVENCIÓN BREVE Y DERIVACIÓN PARA EL TRATAMIENTO DEL USO DE DROGAS EN ATENCIÓN PRIMARIA: VUELTA A LA PIZARRA
 
Saitz R, Palfai TP, Cheng DM, Alford DP, Bernstein JA, Lloyd-Travaglini CA, et al. Screening and brief intervention for drug use in primary care: the ASPIRE randomized clinical trial. JAMA 2014;312:502-513 [EC,II]
25096690             R/C
CRIBAJE E INTERVENCIÓN BREVE PARA EL USO DE DROGAS EN ATENCIÓN PRIMARIA: ENSAYO CLÍNICO ALEATORIZADO ASPIRE
 
Squires D. The global slowdown in health care spending growth. JAMA 2014;312:485-486 [AO,I]
ENLENTECIMIENTO MUNDIAL EN EL CRECIMIENTO DEL GASTO EN ATENCIÓN SANITARIA
 
Kohli A, Shaffer A, Sherman A, Kottilil S. Treatment of hepatitis C: a systematic review. JAMA 2014;312:631-640 [M,II]
25117132             R/C
TRATAMIENTO DE LA HEPATITIS C: REVISIÓN SISTEMÁTICA
 
Reeves GM, Riddle MA. A practical and effective primary care intervention for treating adolescent depression. JAMA 2014;312:797-798 [AO,I]
INTERVENCIÓN PRÁCTICA Y EFECTIVA EN ATENCIÓN PRIMARIA PARA TRATAR LA DEPRESIÓN DEL ADOLESCENTE
 
Dechartres A, Altman DG, Trinquart L, Boutron I, Ravaud P. Association between analytic strategy and estimates of treatment outcomes in meta-analyses. JAMA 2014;312:623-630 [M,I]
25117131             R/C
ASOCIACIÓN ENTRE  ESTRATEGIA ANALÍTICA Y CÁLCULO DE LOS RESULTADOS DE TRATAMIENTO EN LOS METAANÁLISIS
 
Roy-Byrne P, Bumgardner K, Krupski A, Dunn C, Ries R, Donovan D, et al. Brief intervention for problem drug use in safety-net primary care settings: a randomized clinical trial. JAMA 2014;312:492-501 [EC,I]
25096689             R/C
INTERVENCIÓN BREVE PARA EL PROBLEMA DEL USO DE DROGAS EN EL ÁMBITO DE LA RED DE SEGURIDAD DE LA ATENCIÓN PRIMARIA: ENSAYO CLÍNICO ALEATORIZADO
 
Richardson LP, Ludman E, McCauley E, Lindenbaum J, Larison C, Zhou C, et al. Collaborative care for adolescents with depression in primary care: a randomized clinical trial. JAMA 2014;312:809-816 [EC,II]
25157724             R/C
ATENCIÓN COORDINADA PARA LOS ADOLESCENTES CON DEPRESIÓN EN ATENCIÓN PRIMARIA: ENSAYO CLÍNICO ALEATORIZADO
 
 
MacKenzie A. Balancing the benefits and risks of empirical antibiotics for sinusitis: a teachable moment. JAMA Intern Med 2014;174:1221-1222 [AO,I]
EQUILIBRAR LOS BENEFICIOS Y LOS RIESGOS DE LOS ANTIBIÓTICOS EMPÍRICOS PARA LA SINUSITIS: MOMENTO DE ENSEÑANZA
 
Rodriguez CJ, Swett K, Agarwal SK, Folsom AR, Fox ER, Loehr LR, et al. Systolic blood pressure levels among adults with hypertension and incident cardiovascular events: the Atherosclerosis Risk in Communities study. JAMA Intern Med 2014;174:1252-1261 [S,II]
24935209             R/C
NIVELES DE PRESIÓN ARTERIAL SISTÓLICA ENTRE INDIVIDUOS CON HIPERTENSIÓN Y EN LOS QUE APARECEN ACONTECIMIENTOS CARDIOVASCULARES: ESTUDIO ATHEROSCLEROSIS RISK IN COMMUNITIES
 
Lee DS, Markwardt S, Goeres L, Lee CG, Eckstrom E, Williams C, et al. Statins and physical activity in older men: the osteoporotic fractures in men study. JAMA Intern Med 2014;174:1263-1270 [S,II]
24911216             R/C
ESTATINAS Y ACTIVIDAD FÍSICA EN HOMBRES MAYORES: ESTUDIO FRACTURAS OSTEOPORÓTICAS EN HOMBRES
 
 
Waszczuk MA, Zavos HM, Gregory AM, Eley TC. The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood. JAMA Psychiatry 2014;71:905-916 [S,II]
24920372             R/C
ESTRUCTURA FENOTÍPICA Y GENÉTICA DE LA DEPRESIÓN Y LOS SÍNTOMAS DE TRASTORNOS DE ANSIEDAD EN LA NIÑEZ, ADOLESCENCIA Y JUVENTUD
 
Ljung T, Chen Q, Lichtenstein P, Larsson H. Common etiological factors of attention-deficit/hyperactivity disorder and suicidal behavior: a population-based study in Sweden. JAMA Psychiatry 2014;71:958-964 [S,II]
24964928             R/C
FACTORES ETIOLÓGICOS COMUNES DEL TRASTORNO DE HIPERACTIVIDAD Y DÉFICIT DE ATENCIÓN Y EL COMPORTAMIENTO SUICIDA: ESTUDIO POBLACIONAL EN SUECIA
 
 
Martín-Ramiro JJ, Alvarez-Martín E, Gil-Prieto R. Discapacidad atribuible al exceso de peso en España. Med Clin (Barc) 2014;143:150-156 [T,I]
23932567             R/C
Discapacidad atribuible al exceso de peso en España
 
Muñoz de Escalona-Rojas JE, Cantero-Hinojosa J, Garrido-Pareja F, García-Serrano JL, Padilla-Torres JF. Componente hemodinámico en el glaucoma y su asociación con factores de riesgo y enfermedades cardiovasculares. Med Clin (Barc) 2014;143:157-160 [T,I]
24268908             R/C
Componente hemodinámico en el glaucoma y su asociación con factores de riesgo y enfermedades cardiovasculares
 
Dal-Ré R. Acceso público a los resultados de los ensayos clínicos con medicamentos: ¿es esto suficiente para clínicos y pacientes? Med Clin (Barc) 2014;143:180-184 [AO,I]
Acceso público a los resultados de los ensayos clínicos con medicamentos: ¿es esto suficiente para clínicos y pacientes?
 
 
Ghany MG, Gara N. QUEST for a cure for hepatitis C virus: the end is in sight. Lancet 2014;384:381-383 [AO,I]
QUEST (búsqueda o investigación) DE UNA CURA PARA EL VIRUS DE LA HEPATITIS C: EL FINAL ESTÁ A LA VISTA
 
Jacobson IM, Dore GJ, Foster GR, Fried MW, Radu M, Rafalsky VV, et al. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet 2014;384:403-413 [EC,II]
24907225             R/C
SIMEPREVIR CON INTERFERON ALFA 2A PEGILADO MÁS RIBAVIRINA EN EL PRIMER TRATAMIENTO EN PACIENTES CON INFECCIÓN CRÓNICA POR VIRUS DE HEPATITIS C GENOTIPO 1 (QUEST-1): ENSAYO ALEATORIZADO A DOBLE CIEGO CONTROLADO POR PLACEBO EN FASE 3
 
Manns M, Marcellin P, Poordad F, de Araujo ES, Buti M, Horsmans Y, et al. Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2014;384:414-426 [EC,II]
24907224             R/C
SIMEPREVIR CON INTERFERON ALFA 2A O 2B PEGILADO MÁS RIBAVIRINA EN EL PRIMER TRATAMIENTO EN PACIENTES CON INFECCIÓN CRÓNICA POR VIRUS DE HEPATITIS C GENOTIPO 1 (QUEST-2): ENSAYO ALEATORIZADO A DOBLE CIEGO CONTROLADO POR PLACEBO EN FASE 3
 
Skin cancer: prevention is better than cure. Lancet 2014;384:470 [AO,I]
CÁNCER DE PIEL: LA PREVENCIÓN ES MEJOR QUE LA CURA
 
Hallal PC, Martins RC, Ramírez A. The Lancet Physical Activity Observatory: promoting physical activity worldwide. Lancet 2014;384:471-472 [AO,I]
OBSERVATORIO DE ACTIVIDAD FÍSICA DE THE LANCET: PROMOVER LA ACTIVIDAD FÍSICA EN TODO EL MUNDO
 
Schapira AH, Olanow CW, Greenamyre JT, Bezard E. Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives. Lancet 2014;384:545-555 [R,I]
24954676             R/C
ENLENTECIMIENTO DE LA NEURODEGENERACIÓN EN LA ENFERMEDAD DE PARKINSON Y EN LA ENFERMEDAD DE HUNTINGTON: PERSPECTIVAS TERAPÉUTICAS FUTURAS
 
Quantifying the social impact of research and medical journals. Lancet 2014;384:557 [AO,I]
CUANTIFICAR EL IMPACTO SOCIAL DE LA INVESTIGACIÓN Y DE LAS REVISTAS MÉDICAS
 
Prescribing antibiotics: a battle of resistance. Lancet 2014;384:558 [AO,I]
PRESCRIPCIÓN DE ANTIBIÓTICOS: UNA BATALLA DE RESISTENCIA
 
Kastelein JJ. Dyslipidaemia in perspective. Lancet 2014;384:566-568 [AO,I]
LA DISLIPEMIA EN PERSPECTIVA
 
Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, et al; Blood Pressure Lowering Treatment Trialists' Collaboration. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet 2014;384:591-598 [M,II]
25131978             R/C
TRATAMIENTO PARA BAJAR LA PRESIÓN ARTERIAL BASADO EN EL RIESGO CARDIOVASCULAR: METAANÁLISIS DE DATOS INDIVIDUALES DE PACIENTES
 
Ebola: a failure of international collective action. Lancet 2014;384:637 [AO,I]
ÉBOLA: FRACASO DE LA ACCIÓN COLECTIVA INTERNACIONAL
 
Evidence and doubt in the translation of research into care. Lancet 2014;384:638 [AO,I]
EVIDENCIA Y DUDA EN LA TRADUCCIÓN DE LA INVESTIGACIÓN A LA ATENCIÓN SANITARIA
 
High quality care for all in the UK. Lancet 2014;384:716 [AO,I]
ATENCIÓN DE ALTA CALIDAD PARA TODOS EN EL R.U.
 
Ewer AK. Pulse oximetry screening: do we have enough evidence now? Lancet 2014;384:725-726 [AO,I]
CRIBAJE POR PULSIOXIMETRÍA: ¿TENEMOS YA SUFICIENTE EVIDENCIA?
 
Campbell PT. Obesity: a certain and avoidable cause of cancer. Lancet 2014;384:727-728 [AO,I]
OBESIDAD: UNA CAUSA CIERTA Y EVITABLE DE CÁNCER
 
McPherson K. Reducing the global prevalence of overweight and obesity. Lancet 2014;384:728-730 [AO,I]
REDUCIR LA PREVALENCIA MUNDIAL DE CÁNCER Y OBESIDAD
 
Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults. Lancet 2014;384:755-765 [S,II]
25129328             R/C
ÍNDICE DE MASA CORPORAL Y RIESGO DE 22 CÁNCERES ESPECÍFICOS: ESTUDIO DE COHORTE POBLACIONAL DE 5,24 MILLONES DE ADULTOS EN R.U.
 
Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:766-781 [M,II]
24880830             R/C
PREVALENCIA NACIONAL, REGIONAL Y MUNDIAL DE SOBREPESO Y OBESIDAD EN NIÑOS Y ADULTOS ENTRE 1980-2013: ANÁLISIS SISTEMÁTICO PARA EL ESTUDIO DE CARGA MUNDIAL DE ENFERMEDAD DE 2013
 
 
Press MJ. Instant replay--a quarterback's view of care coordination. N Engl J Med 2014;371:489-491 [AO,I]
REPETICIÓN DE LA JUGADA: PUNTO DE VISTA DEL QUARTERBACK* SOBRE LA COORDINACIÓN DE LA ATENCIÓN SANITARIA
*Equivalente en el fútbol americano al centrocampista o al base del baloncesto, el que reparte el juego
 
Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, et al. Breast-cancer risk in families with mutations in PALB2. N Engl J Med 2014;371:497-506 [T,II]
25099575             R/C
RIESGO DE CÁNCER DE MAMA EN FAMILIAS CON MUTACIONES EN PALB2
 
Evans MK, Longo DL. PALB2 mutations and breast-cancer risk. N Engl J Med 2014;371:566-568 [AO,I]
MUTACIONES PALB2 Y RIESGO DE CÁNCER DE MAMA
 
Mente A, O'Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, et al; PURE Investigators. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med 2014;371:601-611 [T,II]
25119606             R/C
ASOCIACIÓN DEL  SODIO URINARIO Y LA EXCRECIÓN DE POTASIO CON LA PRESIÓN ARTERIAL
 
O'Donnell M, Mente A, Rangarajan S, McQueen MJ, Wang X, Liu L, et al; PURE Investigators. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med 2014;371:612-623 [T,II]
25119607             R/C
SODIO URINARIO, EXCRECIÓN DE POTASIO, MORTALIDAD Y ACONTECIMIENTOS CARDIOVASCULARES
 
Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh S, Engell RE, et al; Global Burden of Diseases Nutrition and Chronic Diseases Expert Group. Global sodium consumption and death from cardiovascular causes. N Engl J Med 2014;371:624-634 [T,II]
25119608             R/C
CONSUMO MUNDIAL DE SODIO Y MUERTES POR CAUSAS CARDIOVASCULARES
 
Grant JE. Clinical practice: Obsessive-compulsive disorder. N Engl J Med 2014;371:646-653 [R,I]
25119610             R/C
PRÁCTICA CLÍNICA: TRASTORNO OBSESIVO-COMPULSIVO
 
Oparil S. Low sodium intake--cardiovascular health benefit or risk? N Engl J Med 2014;371:677-679 [AO,I]
INGESTA BAJA DE SODIO ¿BENEFICIO O RIESGO PARA LA SALUD CARDIOVASCULAR?
 
Asch DA, Weinstein DF. Innovation in medical education. N Engl J Med 2014;371:794-795 [AO,I]
INNOVACIÓN EN FORMACIÓN MÉDICA
 
Løberg M, Kalager M, Holme Ø, Hoff G, Adami HO, Bretthauer M. Long-term colorectal-cancer mortality after adenoma removal. N Engl J Med 2014;371:799-807 [S,II]
25162886             R/C
MORTALIDAD A LARGO PLAZO POR CÁNCER COLORRECTAL TRAS EXTIRPACIÓN DE ADENOMA
 
Lieberman D. Colon-polyp surveillance--do patients benefit? N Engl J Med 2014;371:860-861 [AO,I]
VIGILANCIA DE PÓLIPOS COLÓNICOS ¿SE BENEFICIAN LOS PACIENTES?
 
 
Williams MC, Murchison JT, Edwards LD, Agustí A, Bakke P, Calverley PM, et al; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators. Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality. Thorax 2014;69:718-723 [CC,II]
24473329             R/C
LA CALCIFICACIÓN ARTERIAL CORONARIA ESTÁ AUMENTADA EN PACIENTES CON EPOC Y SE ASOCIA CON UNA MAYOR MORBILIDAD Y MORTALIDAD
 
ACADEMIC MEDICINE
 
Internal medicine residents are required to participate in scholarly activity, but conducting original research during residency is challenging. Following a poor Match at Baystate Medical Center, the authors implemented a resident research program to overcome known barriers to resident research. The multifaceted program addressed the following barriers: lack of interest, lack of time, insufficient technical support, and paucity of mentors. The program consisted of evidence-based medicine training to stimulate residents' interest in research and structural changes to support their conduct of research, including protected time for research during ambulatory blocks, a research assistant to help with tasks such as institutional review board applications and data entry, a research nurse to help with data collection, easily accessible biostatistical support, and a resident research director to provide mentorship. Following implementation in the fall of 2005, there was a steady rise in the number of resident presentations at national meetings, then in the number of resident publications. From 2001 to 2006, the department saw 3 resident publications. From 2006 to 2012, that number increased to 39 (P< .001). The department also saw more original research (29 publications) and resident first authors (12 publications) after program implementation. The percentage of residents accepted into fellowships rose from 33% before program implementation to 49% after (P = .04). This comprehensive resident research program, which focused on evidence-based medicine and was tailored to overcome specific barriers, led to a significant increase in the number of resident Medline publications and improved the reputation of the residency program.
There is a gap in the medical education literature on teaching nonverbal detection and expression of empathy. Many articles do not address nonverbal interactions, instead focusing on "what to say" rather than "how to be." This focus on verbal communication overlooks the essential role nonverbal signals play in the communication of emotions, which has significant effects on patient satisfaction, health outcomes, and malpractice claims. This gap is addressed with a novel teaching tool for assessing nonverbal behavior using the acronym E.M.P.A.T.H.Y.-E: eye contact; M: muscles of facial expression; P: posture; A: affect; T: tone of voice; H: hearing the whole patient; Y: your response. This acronym was the cornerstone of a randomized controlled trial of empathy training at Massachusetts General Hospital, 2010-2012. Used as an easy-to-remember checklist, the acronym orients medical professionals to key aspects of perceiving and responding to nonverbal emotional cues. An urgent need exists to teach nonverbal aspects of communication as medical practices must be reoriented to the increasing cultural diversity represented by patients presenting for care. Where language proficiency may be limited, nonverbal communication becomes more crucial for understanding patients' communications. Furthermore, even in the absence of cultural differences, many patients are reluctant to disagree with their clinicians, and subtle nonverbal cues may be the critical entry point for discussions leading to shared medical decisions. A detailed description of the E.M.P.A.T.H.Y. acronym and a brief summary of the literature that supports each component of the teaching tool are provided.
 
ANNALS OF INTERNAL MEDICINE
 
Both groups experienced significant improvement. The manual physical therapy group used less 1-year SIS-related health care resources than the CSI group.
New therapies for HCV infection and widespread implementation of screening and treatment will play an important role in reducing the burden of HCV disease. More aggressive screening recommendations are needed to identify a large pool of infected patients.
 
ATENCION PRIMARIA
 
Although diabetes is clearly associated with increased risk of mortality, it is significant only for patients with =10 years’ history of diabetes.
Se ha obtenido una visión general sobre aquello que según adolescentes y expertos es eficaz o ineficaz en la prevención del consumo de alcohol, y acerca de las claves que se deberían tener en cuenta para diseñar políticas eficaces.
El incumplimiento del tratamiento antidepresivo es elevado en atención primaria desde las primeras semanas tras iniciarlo. Constituyen factores condicionantes del mismo los relacionados con características sociodemográficas y con otras características de los pacientes como tipo de financiación de prestación farmacéutica y frecuentación a las consultas.
El presente trabajo constituye una primera aproximación en castellano al desafío metodológico de incorporar la pluripatología y la comorbilidad a las GPC. El objetivo es conseguir que las GPC sean herramientas realmente útiles en la toma de decisiones en este grupo de población, tanto para profesionales como para pacientes. Es necesario progresar en una propuesta metodológica con la participación de más agentes (responsables sanitarios, expertos en metodología, cuidadores y pacientes, otras sociedades científicas, etc.). En el contexto de nuestro Sistema Nacional de Salud, Guiasalud, como organismo responsable del desarrollo metodológico de GPC, sería el agente más adecuado para coordinar el proceso.
 
BRITISH MEDICAL JOURNAL
 
This large cohort study found a significantly increased risk of cardiac death associated with clarithromycin. No increased risk was seen with roxithromycin. Given the widespread use of clarithromycin, these findings call for confirmation in independent populations.
BCG protects against M tuberculosis infection as well as progression from infection to disease.Trial registration PROSPERO registration No CRD42011001698 (www.crd.york.ac.uk/prospero/).
The QBleed algorithms provided valid measures of absolute risk of gastrointestinal and intracranial bleed in patients with and without anticoagulation as shown by the performance of the algorithms in a separate validation cohort. Further research is needed to evaluate the clinical outcomes and the cost effectiveness of using these algorithms in primary care.
 
DIABETES CARE
 
This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT.
Our study is consistent with current recommendations that the renal function of metformin users should be adequately monitored and that the dose of metformin should be adjusted, if necessary, if renal function falls below 60 mL/min/1.73 m(2).
In a real-world setting, the risk of new-onset diabetes rises as adherence with statin therapy increases. Benefits of statins in reducing cardiovascular events clearly overwhelm the diabetes risk.
Increased inflammation may be involved in the pathogenesis of depressive symptoms in type 2 diabetes and contribute to the increased risk of complications and mortality in this group.
Dulaglutide improves glycemic control and is well tolerated as monotherapy in patients with early stage type 2 diabetes.
Both dulaglutide doses demonstrated superior glycemic control versus sitagliptin at 52 weeks with an acceptable tolerability and safety profile.
Consistency of glycemic control is important to reduce the risks of vascular events and death in type 2 diabetes.
The overall LA incidence rate for patients on metformin in this study was within the range of rates reported in the literature for patients with type 2 diabetes, and no significant difference was observed among patients with N, Mi, Mo, and Se function.
 
DRUGS
 
Functional esophageal disorders are a group of disorders that cause esophageal symptoms, although with negative results on investigation with standard esophageal tests. Therefore, structural disorders, motility disorders with a histopathological basis and gastroesophageal reflux disease (GERD) are excluded. They are frequently encountered by clinicians, and so a systematic and evidence-based approach to investigation, diagnosis and treatment are crucial. There are four functional esophageal disorders defined by the ROME III consensus, namely functional heartburn, functional chest pain, functional dysphagia and globus. Since the advent of ROME, the specification of diagnostic criteria for functional esophageal disorders has allowed more comparable studies and clinical trials. Despite this, the evidence base for many therapies in use at present is not as robust as would be desired. In this paper, we discuss the four categories of functional esophageal disorders. We then propose diagnostic algorithms based on current evidence. Finally, we discuss current therapies for each of the four functional esophageal disorders based on current evidence.
 
FAMILY PRACTICE
 
Among the wide range of psychosocial risk factors, research has focused mainly on pain beliefs and coping skills, with disappointing results. Extended theoretical models integrating several psychosocial factors and multicomponent interventions are probably required to meet the challenge of LBP.
Prodromal symptoms of PD are encountered in general practice. GPs should be alert when patients present with multiple prodromal symptoms in a two-year period, especially considering the benefits of early intervention, and the future possibilities for disease-modifying therapy.
Primary preventive care activity was related to the characteristics of GPs' patients and practice organizational markers and not to GPs' personal characteristics.
As many patients on longer term courses of antidepressants are not being appropriately reviewed, a 'chronic disease management approach' to depression in primary care is advocated.
This study of GPs' attitudes towards generic medicines in Ireland highlights that this key stakeholder group has generally positive attitudes towards both generic medicines and the new legislation. However, variable knowledge about generic medicines and concerns regarding patient experience, clinical effectiveness and manufacturing quality were identified. GPs' opinions could negatively influence patient opinions; enhancing such opinions may prove important in successfully implementing the new legislation.
The single self-assessment item has high sensitivity and moderate specificity to identify possible cases of depression when used at a threshold of mild depression or greater
 
GUT
 
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterology. Areas of controversies were explored through phone meetings and web surveys. Nine working groups examined the following areas of CD diagnosis and management: classification of CD; genetics and immunology; diagnostics; serology and endoscopy; follow-up; gluten-free diet; refractory CD and malignancies; quality of life; novel treatments; patient support; and screening for CD.
HBsAg seroclearance achieved after NUC treatment was associated with favourable clinical outcomes and was durable in most cases during long-term follow-up.
 
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
 
In Norway, once-only flexible sigmoidoscopy screening or flexible sigmoidoscopy and FOBT reduced colorectal cancer incidence and mortality on a population level compared with no screening. Screening was effective both in the 50- to 54-year and the 55- to 64-year age groups.
Treatment planning for persistent pain in later life requires a clear understanding of the patient's treatment goals and expectations, comorbidities, and cognitive and functional status, as well as coordinating community resources and family support when available. A combination of pharmacologic, nonpharmacologic, and rehabilitative approaches in addition to a strong therapeutic alliance between the patient and physician is essential in setting, adjusting, and achieving realistic goals of therapy.
Brief intervention did not have efficacy for decreasing unhealthy drug use in primary care patients identified by screening. These results do not support widespread implementation of illicit drug use and prescription drug misuse screening and brief intervention.
New, short-duration, simpler therapies result in high SVR rates for HCV-infected patients. In conjunction with increased screening for HCV as suggested by recent Centers for Disease Control and Prevention guidelines, availability of new therapies may lead to the treatment of many more people with chronic HCV infection.
Estimation of treatment outcomes in meta-analyses differs depending on the strategy used. This instability in findings can result in major alterations in the conclusions derived from the analysis and underlines the need for systematic sensitivity analyses.
A one-time brief intervention with attempted telephone booster had no effect on drug use in patients seen in safety-net primary care settings. This finding suggests a need for caution in promoting widespread adoption of this intervention for drug use in primary care.
Among adolescents with depression seen in primary care, a collaborative care intervention resulted in greater improvement in depressive symptoms at 12 months than usual care. These findings suggest that mental health services for adolescents with depression can be integrated into primary care.
 
JAMA INTERNAL MEDICINE
 
Among patients with HTN, having an elevated SBP carries the highest risk for cardiovascular events, but in this categorical analysis, once SBP was below 140 mm Hg, an SBP lower than 120 mm Hg did not appear to lessen the risk of incident CV events.
Statin use was associated with modestly lower physical activity among community-living men, even after accounting for medical history and other potentially confounding factors. The clinical significance of these findings deserves further investigation.
 
JAMA PSYCHIATRY
 
These results provide preliminary evidence for different phenotypic and genetic structures of internalizing disorder symptoms in childhood, adolescence, and young adulthood, with depression and anxiety becoming more associated from adolescence. The results inform molecular genetics research and transdiagnostic treatment approaches. The findings affirm the need to continue examining the classification of mood and anxiety disorders in diagnostic systems.
Attention-deficit/hyperactivity disorder is associated with an increased risk of both attempted and completed suicide. The pattern of familial risks across different levels of relatedness suggests that shared genetic factors are important for this association. This is an important first step toward identifying the underlying mechanisms for the risk of suicidal behavior in patients with attention-deficit/hyperactivity disorder and suggests that individuals with attention-deficit/hyperactivity disorder and their family members are important targets for suicide prevention and treatment.
 
MEDICINA CLINICA
 
El exceso de peso conlleva una importante carga de discapacidad asociada, así como de consumo de recursos sociosanitarios. Los AVD perdidos es una útil herramienta que permite cuantificar de forma numérica la importancia relativa de los distintos problemas de salud, así como realizar estudios comparativos entre distintas enfermedades y monitorizar en el tiempo la eficacia de las medidas encaminadas a su control.
There is a statistically significant association between the presence of CVD and/or CVRF and glaucomatous disease, a finding that is supplemented with data from the OHV. These values indicate a worst ocular perfusion in patients with glaucomatous disease.
 
THE LANCET
 
Addition of simeprevir to either peginterferon alfa 2a or peginterferon alfa 2b plus ribavirin improved SVR in treatment-naive patients with HCV genotype 1 infection, without worsening the known adverse events associated with peginterferon alfa plus ribavirin.
Simeprevir once daily with peginterferon alfa 2a and ribavirin shortens therapy in treatment-naive patients with HCV genotype 1 infection without worsening the adverse event profiles associated with peginterferon alfa 2a plus ribavirin.
Several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease and Huntington's disease. These advances have been informed by both direct analysis of the post-mortem brain and by study of the biological consequences of the genetic causes of these diseases. Some of the pathways that have been implicated so far include mitochondrial dysfunction, oxidative stress, kinase pathways, calcium dysregulation, inflammation, protein handling, and prion-like processes. Intriguingly, these pathways seem to be important in the pathogenesis of both diseases and have led to the identification of molecular targets for candidate interventions designed to slow or reverse their course. We review some recent advances that underlie putative therapies for neuroprotection in Parkinson's disease and Huntington's disease, and potential targets that might be exploited in the future. Although we will need to overcome important hurdles, especially in terms of clinical trial design, we propose several target pathways that merit further study. In Parkinson's disease, these targets include agents that might improve mitochondrial function or increase degradation of defective mitochondria, kinase inhibitors, calcium channel blockers, and approaches that interfere with the misfolding, templating, and transmission of a-synuclein. In Huntington's disease, strategies might also be directed at mitochondrial bioenergetics and turnover, the prevention of protein dysregulation, disruption of the interaction between huntingtin and p53 or huntingtin-interacting protein 1 to reduce apoptosis, and interference with expression of mutant huntingtin at both the nucleic acid and protein levels.
Lowering blood pressure provides similar relative protection at all levels of baseline cardiovascular risk, but progressively greater absolute risk reductions as baseline risk increases. These results support the use of predicted baseline cardiovascular disease risk equations to inform blood pressure-lowering treatment decisions.
BMI is associated with cancer risk, with substantial population-level effects. The heterogeneity in the effects suggests that different mechanisms are associated with different cancer sites and different patient subgroups.
Because of the established health risks and substantial increases in prevalence, obesity has become a major global health challenge. Not only is obesity increasing, but no national success stories have been reported in the past 33 years. Urgent global action and leadership is needed to help countries to more effectively intervene.
 
THE NEW ENGLAND JOURNAL OF MEDICINE
 
After a median of 7.7 years of follow-up, colorectal-cancer mortality was lower among patients who had had low-risk adenomas removed and moderately higher among those who had had high-risk adenomas removed, as compared with the general population. (Funded by the Norwegian Cancer Society and others.).
A 19-year-old man is brought to his primary physician by his father, who explains that his son washes his hands a hundred times a day, will not touch anything that has been touched by someone else without scrubbing it first, and has a fear of germs that has left him isolated in his bedroom, unable to eat, and wishing he were dead. Although the father reports that his son has always been finicky, this problem started approximately 2 years ago and has gradually become completely disabling. How should this patient be evaluated and treated?
In this study in which sodium intake was estimated on the basis of measured urinary excretion, an estimated sodium intake between 3 g per day and 6 g per day was associated with a lower risk of death and cardiovascular events than was either a higher or lower estimated level of intake. As compared with an estimated potassium excretion that was less than 1.50 g per day, higher potassium excretion was associated with a lower risk of death and cardiovascular events. (Funded by the Population Health Research Institute and others.).
In this study, the association of estimated intake of sodium and potassium, as determined from measurements of excretion of these cations, with blood pressure was nonlinear and was most pronounced in persons consuming high-sodium diets, persons with hypertension, and older persons. (Funded by the Heart and Stroke Foundation of Ontario and others.).
Loss-of-function mutations in PALB2 are an important cause of hereditary breast cancer, with respect both to the frequency of cancer-predisposing mutations and to the risk associated with them. Our data suggest the breast-cancer risk for PALB2 mutation carriers may overlap with that for BRCA2 mutation carriers. (Funded by the European Research Council and others.).
In this modeling study, 1.65 million deaths from cardiovascular causes that occurred in 2010 were attributed to sodium consumption above a reference level of 2.0 g per day. (Funded by the Bill and Melinda Gates Foundation.).
 
THORAX
 
Patients with COPD have more CAD than controls and this is associated with increased dyspnoea, reduced exercise capacity and increased mortality. These data indicate that the presence of CAD in patients with COPD is associated with poor clinical outcomes.
 
 
 
 

                      

XXVIII Congreso de Comunicación y Salud

 

 

21 Jor. Residentes y Tutores semFYC

 


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